A5048972982- Reproductive System and Pregnancy
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Microtubule and mitosis dynamics
- Corneal Surgery and Treatments
- Cellular Mechanics and Interactions
- Immunotherapy and Immune Responses
- Silk-based biomaterials and applications
- Ferrocene Chemistry and Applications
- Endometriosis Research and Treatment
- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- Research on Leishmaniasis Studies
- Plant Reproductive Biology
- HER2/EGFR in Cancer Research
- Sexual Differentiation and Disorders
- Peptidase Inhibition and Analysis
- Trypanosoma species research and implications
- Cancer Cells and Metastasis
- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
- Pregnancy and Medication Impact
- Ubiquitin and proteasome pathways
Academic Center for Education, Culture and Research
2012-2024
Biotechnology Research Center
2012-2018
Royan Institute
2012-2015
Pasteur Institute of Iran
2012
In recent decades, stem cell therapy has been introduced as a novel therapeutic approach for patients suffering from bone disorders. Recently, menstrual blood identified an easily accessible and recycled source. However, the osteogenic differentiation capacity of blood-derived cells (MenSCs) compared with other adult remained unsolved. The aim this study was to investigate MenSCs marrow-derived mesenchymal (BMSCs) in presence human platelet releasate (HPR). Our results showed that were...
Abstract Objective To determine the geographical distribution of Leishmania species causing cutaneous leishmaniasis (CL) and to study genetic heterogeneity major isolates from different endemic areas Iran. Methods A total 341 lesions patients living in 11 provinces Iran were grown culture medium inoculated BALB/c mice detect possible visceralisation. The identified by isoenzyme analysis using a battery six enzymes kinetoplast (k) DNA‐PCR technique. Genetic variation among L. was analysed...
Silymarin as an herbal drug has potent antioxidant effects that could make it a good choice for endometriosis therapy. The aim of the current study was to determine silymarin on induced endometrial lesion in rat model endometriosis.A total 32 mature, female Sprague-Dawley rats were allocated into 4 experimental groups. duration about 6 months. Endometriosis implants surgically prepared and autografted rats. Three weeks after induction, animals randomly four groups: Group 1 received...
Introduction Failure to adequate decidualization leads adverse pregnancy outcomes including loss. Although there are plenty of reports underscoring immune dysfunction as the main cause abortion in CBA/J females mated with DBA/2 males (CBA/J × DBA/2), little is known about potential role impaired endometrial decidualization. Methods Endometrial stromal cells (ESCs) from mice were in-vitro decidualized, and proteome profile secretome was investigated by membrane-based array. perfused In-utero...
Many types of tumors are organized in a hierarchy heterogeneous cell populations with different molecular signature. Such heterogeneity may be associated responsiveness to microenvironment stimuli. In the present study, effects lipopolysaccharide (LPS) and lipoteichoic acid (LTA), as well-known mediators inflammation, on cancerous behavior three prostate tumor cells, LNCaP, PC3 DU145, were investigated.Expression TLR1-10, CD14 MyD88 transcripts was investigated by RT-PCR. Protein expression...
Cisplatin as a platinum (Pt)-based chemotherapeutic compound is commonly applied for the treatment of several types cancer. Nonetheless, drug resistance and severe adverse effects have been observed upon using cisplatin. Here, we explored cytotoxicity novel Pt-based compounds on cancer cell lines.Five synthetic Pt well cisplatin were investigated by XTT assay to determine their against lines originated from prostate, ovary, breast cancers at different time periods various concentrations....
Kisspeptins (KPs) are major regulators of trophoblast and cancer invasion. Thus far, limited conflicting data available on KP-mediated modulation breast (BC) metastasis; mostly based synthetic KP-10, the most active fragment KP. Here, we report for first time comprehensive functional effects term placental KPs proliferation, adhesion, Matrigel invasion, motility, MMP activity pro-inflammatory cytokine production in MDA-MB-231 (estrogen receptor-negative) MCF-7 receptor-positive). were...
In this study we differentially showed the effects of cell-seeded bilayer scaffold wound dressing in accelerating healing process diabetic ulcers that still remains as a major clinical challenge. The aim was to compare immunomodulatory and angiogenic activity, regenerative effect differences between Menstrual blood-derived Stem Cells (MenSCs) foreskin-derived keratinocytes/fibroblasts.The streptozotocin-induced mice model developed male C57/BL6 mice. A fabricated by electrospining silk...
Background: Sortilin has an important role in various malignances and can be used as a promising target to eradicate cancer cells. Methods: In this study, the expression of sortilin 4T1 MDA-MB231 cell lines was evaluated by flow cytometry immunocytochemistry. Apoptosis assay also applied evaluate apoptosis induction lines. Results: Based on surface results, anti-sortilin (2D8-E3) mAb could recognize molecules 79.2% 90.3% cell-lines, respectively. The immunocytochemistry staining results...
Abstract Sortilin has an important role to play in various malignances and can be used as a promising target eradicate cancer cells. The expression of sortilin 4T1 MDA-MB231 was evaluated by flow cytometry immunocytochemistry. Apoptosis test also performed. Based on cell surface results 2D8-E3 mAb could recognize molecules 45.9% 90.3% cells respectively. immunocytochemistry staining verified expression. assay indicated that induce apoptosis lines. Our study revealed the breast carcinoma...