A5089758560- Neurotransmitter Receptor Influence on Behavior
- Cancer Treatment and Pharmacology
- Optimism, Hope, and Well-being
- Color perception and design
- Decision-Making and Behavioral Economics
- Bayesian Modeling and Causal Inference
- Nicotinic Acetylcholine Receptors Study
- Psychedelics and Drug Studies
- Advanced Breast Cancer Therapies
- Child and Animal Learning Development
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Chemokine receptors and signaling
- Psychology of Moral and Emotional Judgment
- Heart Rate Variability and Autonomic Control
- Receptor Mechanisms and Signaling
- Immune responses and vaccinations
- Immune cells in cancer
- Medical Imaging Techniques and Applications
- Advanced Biosensing Techniques and Applications
- Categorization, perception, and language
- Neuroendocrine Tumor Research Advances
- Embodied and Extended Cognition
- Epistemology, Ethics, and Metaphysics
Monash University
2021-2025
University of Amsterdam
2022-2024
Australian Regenerative Medicine Institute
2024
Massachusetts General Hospital
2022-2023
Icahn School of Medicine at Mount Sinai
2020-2022
Although the first nanomedicine was clinically approved more than two decades ago, nanoparticles' (NP) in vivo behavior is complex and immune system's role their application remains elusive. At present, only passive-targeting nanoformulations have been approved, while complicated active-targeting strategies typically fail to advance from early clinical phase stage. This absence of translation is, among others, due very limited understanding for targeting mechanisms. Dynamic phenomena such as...
Abstract In recent years, cardiovascular immuno-imaging by positron emission tomography (PET) has undergone tremendous progress in preclinical settings. Clinically, two approved PET tracers hold great potential for inflammation imaging patients, namely FDG and DOTATATE. While the former is a widely applied metabolic tracer, DOTATATE relatively new tracer targeting somatostatin receptor 2 (SST2). current study, we performed detailed, head-to-head comparison of DOTATATE-based radiotracers [ 18...
The optimism bias is a cognitive where individuals overestimate the likelihood of good outcomes and underestimate bad outcomes. Associated with improved quality life, considered to be adaptive promising avenue research for mental health interventions in conditions lack such as major depressive disorder. Here we lay groundwork future on an intervention by introducing domain general formal model bias, which can applied different task settings. Employing active inference framework, propose high...
Abstract Since Tversky argued that similarity judgments violate the three metric axioms, asymmetrical have been particularly challenging for standard, geometric models of similarity, such as multidimensional scaling. According to Tversky, are driven by differences in salience or extent knowledge. However, notion has difficult operationalize, especially perceptual stimuli which there no apparent To investigate between stimuli, across experiments, we collected data where individuals would rate...
Abstract Psilocybin has shown promise as a novel pharmacological intervention for treatment of depression, where post-acute effects psilocybin have been associated with increased positive mood and decreased pessimism. Although is proving to be effective in clinical trials psychiatric disorders, the information processing mechanisms affected by are not well understood. Here, we fit computational models underlying decision-making behaviour rats. The model revealed that rats treated achieve...
While causal reasoning is a core facet of our cognitive abilities, its time-course has not received proper attention. As the duration might prove crucial in understanding underlying processes, we asked participants two experiments to make probabilistic inferences while manipulating time pressure. We found that are less accurate under pressure, speed-accuracy-tradeoff, and they respond more conservatively. Surprisingly, other persistent errors—Markov violations failures explain away—appeared...
The optimism bias is a cognitive where individuals overestimate the likelihood of good outcomes and underestimate bad outcomes. Associated with improved quality life, considered to be adaptive promising avenue research for mental health interventions in conditions lack such as major depressive disorder. Here we lay groundwork future on an intervention by introducing domain general formal model bias, which can applied different task settings. Employing active inference framework, propose...
Abstract Background: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in combination with endocrine therapy (ET) provide significant clinical benefit patients HR+/HER2- metastatic breast cancer (MBC) and have become a standard of care treatment. Prior insights from tumor profiling preclinical analyses suggest that AKT1 activation can induce CDK4/6i resistance. We hypothesized targeting following progression may be an effective therapeutic strategy conducted trial to evaluate both doublet...
Causal reasoning is a core facet of our cognitive abilities. However, the time-course causal not studied to its fullest. The duration reasoning, including those that yield error, might prove crucial in understanding processes underlying reasoning. In two experiments we asked participants make probabilistic inferences while manipulating external time pressure and measuring response times. We found are less accurate under pressure, which can be interpreted as speed-accuracy-tradeoff. addition,...
Karl Friston’s free-energy principle casts agents as self-evidencing through active inference. This implies that decision-making, planning and information-seeking are, in a generic sense, ‘wishful’. We take an interdisciplinary perspective on this perplexing aspect of the unpack epistemological implications wishful thinking under principle. use epistemic framing to discuss emergence biases for agents. In particular, we argue elucidates optimism bias foundational tenet self-evidencing. allude...
Since Tversky (1977) argued that similarity judgments violate the three metric axioms, asymmetrical have been offered as particularly difficult challenges for standard, geometric models of similarity, such multidimensional scaling. According to (1977), are driven by differences in salience or extent knowledge. However, notion has operationalize different kinds stimuli, especially perceptual stimuli which there no apparent To investigate between across experiments we collected data where...
Abstract Background: The cyclin-dependent kinase 4/6 inhibitors, with endocrine therapy (ET), have become the standard of care for patients HR+/HER2- MBC. Prior insight from tumor biopsies and preclinical analyses suggest that AKT1 activation can provoke CDK4/6i resistance, highlighting a potential therapeutic role AKT inhibition (AKTi) in this setting. However, combinatorial be associated significant toxicity identification optimal biological dose is often challenging. In translational...
Abstract The somatostatin receptor 2-binding PET tracer DOTATATE is emerging as an alternative to 18 F-FDG assess cardiovascular inflammation. strengths and weaknesses of each their different specificity for inflammatory cells still need be fully elucidated. In this manuscript, we employed mouse rabbit animal models mice, 64 Cu-DOTATATE’s pharmacokinetics timed biodistribution were determined in control (C57BL/6) atherosclerotic ( Apoe −/− ) mice by ex vivo gamma counting. PET/CT, combined...