A5016384733- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Neuroendocrine regulation and behavior
- Eating Disorders and Behaviors
- Autism Spectrum Disorder Research
- X-ray Diffraction in Crystallography
- Receptor Mechanisms and Signaling
- Crystallization and Solubility Studies
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Diet and metabolism studies
- Diverse academic research themes
- Nicotinic Acetylcholine Receptors Study
- Neuropeptides and Animal Physiology
- Neurological disorders and treatments
- Obsessive-Compulsive Spectrum Disorders
- Art, Technology, and Culture
- Traditional and Medicinal Uses of Annonaceae
- Vitamin D Research Studies
- Regulation of Appetite and Obesity
- Cannabis and Cannabinoid Research
- Plant biochemistry and biosynthesis
- Genetics and Neurodevelopmental Disorders
- Biochemical Analysis and Sensing Techniques
- Neural dynamics and brain function
Australian Regenerative Medicine Institute
2022-2024
Monash University
2022-2024
Discovery Institute
2023
The University of Queensland
2016-2023
Abstract Psilocybin has shown promise for alleviating symptoms of depression and is currently in clinical trials the treatment anorexia nervosa (AN), a condition that characterised by persistent cognitive inflexibility. Considering enhanced flexibility after psilocybin reported to occur individuals with depression, it plausible could improve AN breaking down A mechanistic understanding actions required tailor application most likely respond positive outcomes. This can only be achieved using...
Anorexia nervosa (AN) is a complex psychiatric disorder characterised by severe pathological weight loss and persistent cognitive inflexibility. Converging evidence from neuroimaging studies genome-wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) striatum dysfunction in pathophysiology AN. However, identifying causal role circuit-specific genes development AN-like phenotype remains challenging requires combination novel molecular tools preclinical models. The...
Abstract Cubane was recently validated as a phenyl ring (bio)isostere, but highly strained caged carbocyclic systems lack π character, which is often critical for mediating key biological interactions. This electronic property restriction associated with cubane has been addressed herein cyclooctatetraene (COT), using known pharmaceutical and agrochemical compounds templates. COT either outperformed or matched in multiple cases suggesting that versatile complementarity exists between the two...
Epidemiological studies have shown that up to one third of adults insufficient levels vitamin D and there is an association between low concentrations adverse brain outcomes, such as depression. Vitamin has been be involved in processes associated with neurogenesis during development. Therefore, the aim this study was test hypothesis adult (AVD) deficiency BALB/c mice (a) hippocampal at baseline, b) following 6 weeks voluntary wheel running (c) a depressive-like phenotype on forced swim...
Anorexia nervosa has among the highest mortality rates of any psychiatric disorder and is characterized by cognitive inflexibility that persists after weight recovery contributes to chronic nature condition. What remains unknown whether predisposes individuals anorexia nervosa, a question difficult address in human studies. Our previous work using most well-established animal model known as activity-based (ABA) identified neurobiological link between susceptibility pathological loss female...
Abstract Psilocybin has shown promise for alleviating symptoms of depression and is currently in clinical trials the treatment anorexia nervosa (AN), a condition that characterised by persistent cognitive inflexibility. Considering enhanced flexibility after psilocybin reported to occur individuals with depression, it plausible could improve AN breaking down A mechanistic understanding actions required tailor application most likely respond positive outcomes. This can only be achieved using...
Corticostriatal circuits, particularly the dorsomedial striatum (DMS) and lateral orbitofrontal cortex, are critical for navigating reversal learning under probabilistic uncertainty. These same areas implicated in impairments observed individuals with psychosis as well their psychotic symptoms, suggesting that they may share a common neurobiological substrate. To address this question, we used psychostimulant exposure specific activation of DMS during mice to assess corticostriatal...
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Dopamine levels in the dorsomedial striatum (DMS) are highly dynamic and thought to underly encoding of action-outcome associations. Although it is known that amphetamine disrupts learning required for goal-directed action, role D1 D2 receptors this process has not been established. In study, we examined receptor antagonists on response amphetamine. We used outcome-specific devaluation task examine action male C57BL6/J mice treated systemically with either a antagonist (SCH-23990; 0.01...
Dopamine levels in the dorsomedial striatum (DMS) are highly dynamic and thought to underly encoding of action-outcome associations. Although it is known that amphetamine disrupts learning required for goal-directed action, role D1 D2 receptors this process has not been established. In study, we examined receptor antagonists on response amphetamine. We used outcome-specific devaluation task examine action male C57BL6/J mice treated systemically with either a antagonist (SCH-3990; 0.0mg/kg)...
Abstract Anorexia nervosa (AN) has among the highest mortality rates of any psychiatric disorder and is characterised by cognitive inflexibility that persists after weight recovery contributes to low recovery. What remains unknown whether predisposes individuals AN, a question difficult determine from human studies. Our previous work using most well-established animal model known as activity-based anorexia (ABA) identified neurobiological link between susceptibility pathological loss in...