A5010010872- Eating Disorders and Behaviors
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- Obesity, Physical Activity, Diet
- Diabetes and associated disorders
- Tryptophan and brain disorders
- Nerve injury and regeneration
Monash University
2017-2024
Australian Regenerative Medicine Institute
2020-2024
Discovery Institute
2023
Abstract Psilocybin has shown promise for alleviating symptoms of depression and is currently in clinical trials the treatment anorexia nervosa (AN), a condition that characterised by persistent cognitive inflexibility. Considering enhanced flexibility after psilocybin reported to occur individuals with depression, it plausible could improve AN breaking down A mechanistic understanding actions required tailor application most likely respond positive outcomes. This can only be achieved using...
Abstract Psilocybin has shown promise as a novel pharmacological intervention for treatment of depression, where post-acute effects psilocybin have been associated with increased positive mood and decreased pessimism. Although is proving to be effective in clinical trials psychiatric disorders, the information processing mechanisms affected by are not well understood. Here, we fit computational models underlying decision-making behaviour rats. The model revealed that rats treated achieve...
Abstract Objective Identifying risk factors that contribute to the development of anorexia nervosa (AN) is critical for implementation early intervention strategies. Anxiety, obsessive–compulsive behavior, and immune dysfunction may be involved in AN; however, their direct influence on susceptibility condition remains unclear. Here, we used activity‐based (ABA) model examine whether activity, anxiety‐like compulsive circulating markers predict subsequent pathological weight loss. Method...
Anorexia nervosa has among the highest mortality rates of any psychiatric disorder and is characterized by cognitive inflexibility that persists after weight recovery contributes to chronic nature condition. What remains unknown whether predisposes individuals anorexia nervosa, a question difficult address in human studies. Our previous work using most well-established animal model known as activity-based (ABA) identified neurobiological link between susceptibility pathological loss female...
Abstract Background The ability to adapt behavior changing environmental circumstances, or cognitive flexibility , is impaired in multiple psychiatric conditions, including anorexia nervosa (AN). Exaggerated prefrontal cortical activity likely underpins the inflexible thinking and rigid behaviors exhibited by patients with AN. A better understanding of neural basis necessary enable treatment approaches that may target executive control. Methods Utilizing activity-based (ABA) rat model...
Brain-derived neurotrophic factor (BDNF) is abundantly expressed in brain regions involved both homeostatic and hedonic feeding, it circulates at reduced levels patients with anorexia nervosa (AN). A single nucleotide polymorphism the gene encoding for BDNF (Val66Met) has been associated worse outcomes AN, shown to promote anorectic behaviour a mouse model of caloric restriction paired social isolation stress. Previous animal models Val66Met have mice because greater ease modification...
Abstract Anorexia nervosa (AN) has high rates of mortality and low recovery, with outcomes that worsen illness duration. Improved early intervention strategies are required identifying risk factors contribute to the development AN is critical their implementation. The often follows a pre-existing diagnosis anxiety disorders obsessive-compulsive disorder substantial genetic overlap between these conditions suggest common underlying features may predict vulnerability AN. Moreover, patients...
Abstract Anorexia nervosa (AN) has among the highest mortality rates of any psychiatric disorder and is characterised by cognitive inflexibility that persists after weight recovery contributes to low recovery. What remains unknown whether predisposes individuals AN, a question difficult determine from human studies. Our previous work using most well-established animal model known as activity-based anorexia (ABA) identified neurobiological link between susceptibility pathological loss in...