A5017715920- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Medical Imaging Techniques and Applications
- Neuroscience and Neural Engineering
- Meningioma and schwannoma management
- Neurological disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Muscle activation and electromyography studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Orthopedic Surgery and Rehabilitation
- Spinal Cord Injury Research
- Nanoparticle-Based Drug Delivery
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Head and Neck Surgical Oncology
- Traumatic Brain Injury and Neurovascular Disturbances
- Global Health and Surgery
- Botulinum Toxin and Related Neurological Disorders
Medical College of Wisconsin
2020-2025
Marquette University
2020-2024
Froedtert Hospital
2021-2023
Creative Commons
2023
Duke Medical Center
2013-2020
Duke University Hospital
2013-2020
Duke University
2014-2020
University of California, San Francisco
2020
Oxford University Press (United Kingdom)
2018
Neurological Surgery
2018
Autopsy-based radio-pathomic maps of glioma pathology have shown substantial promise inidentifying areas non-enhancing tumor presence, which may be able to differentiate subsets patients that respond favorably treatments such as bevacizumab mixed efficacy evidence. We tested the hypthesis phenotypes fronts can distinguish between glioblastoma will and visually capture treatment response.
Abstract Introduction This study determines the relationship between diffusion and perfusion-based MRI signatures radio-pathomic maps of tumor pathology in a large, multi-site cohort. Methods included perfusion imaging from pre-surgical relative cerebral blood volume (rCBV) images UPenn-GBM dataset arterial spin labeling (ASL) UCSF-PDGM dataset. Diffusion fractional anisotropy (FA) estimates derived tensor (DTI) for each subject institution. A previously validated autopsy-based model was...
INTRODUCTION: Glioblastoma (GBM) is the most common primary CNS malignancy, with one- and five-year survival rates of 41% 5%, respectively. Extent resection correlates increased survival, but tools to predict long-term survivors (LTS) after gross-total (GTR) are lacking. Radio-pathomic maps cell density, trained using MRI autopsy tissue, identify tumor features not readily identifiable on traditional MRI. This study evaluates these in GBM survivors. METHODS: Using UCSF-PDGM dataset, we...
INTRODUCTION: Brain tumors frequently cause impairments in hand dexterity, and we recently demonstrated that standard manual muscle testing greatly underestimates such dysfunction. Because classical anatomical lesioning studies have not fully explained higher order motor performance, there has been recent interest examining inter-network brain connectivity as a potentially more direct functional-anatomical relationship. METHODS: 20 patients with contrast enhancing underwent preoperative...
INTRODUCTION: Interest in stimulation-induced neuroplasticity (i.e., “prehabilitation”) is growing. Potential applications include remapping the brain around invasive tumors to extend resections into previously unresectable areas while protecting neurological function. To achieve this goal, focal cortical stimulation must functionally inhibit a portion of so physiotherapy can encourage other parts network assume its While clinical 50-60 Hz) language cortex inhibits function, primary motor...
INTRODUCTION: In neurosurgical ICUs, external ventriculostomy drain (EVD) transducers are zeroed using one of two methods: an “open” method (removing the non-vented cap from transducer) or a “closed” (lowering buretrol to zero). While closed has advantage maintaining closed, sterile system, it goes against manufacturer guidelines and may compromise accuracy. METHODS: This was blinded, prospective bench study. An EVD collection system (Integra) connected saline bag. The height bag changed...
During typical movements, signals related to both the kinematics and kinetics of movement are mutually correlated, each is correlated some extent with discharge neurons in primary motor cortex (M1). However, it well known, if not always appreciated, that causality cannot be inferred from correlations. Although these mutual correlations persist, their nature changes changing postural or dynamical conditions. Under conditions, only directly controlled by M1 can expected maintain a stable...
Background: Premature fusion of the cranial sutures can lead to significant neurocognitive, developmental, and esthetic consequences, especially if not corrected within first year life. This study aimed identify drivers delayed vault reconstruction (CVR) its impact on complication 30-day readmission rates among craniosynostosis patients. Methods: The medical records all children who underwent CVR for between 2005 2017 at an academic institution were retrospectively reviewed. A delay in...
Abstract BACKGROUND The Responsive Neurostimulation (RNS)® System (NeuroPace, Inc) is an implantable device designed to improve seizure control in patients with medically refractory focal epilepsy. Because it relatively new, surgical pearls and operative techniques optimized from experience beyond a small case series have yet be described. OBJECTIVE To provide detailed description of our technique learned implantation the RNS 57 at institution. We describe method for frame-based placement...
Abstract Background In clinical and research settings, hand dexterity is often assessed as finger individuation, or the ability to move one at a time. Despite its importance, there currently no standardized, sufficiently sensitive, fully objective platform for these evaluations. Methods Here we developed two novel individuation scores tested them against previously score using commercially available instrumented glove data collected from 20 healthy adults. Participants performed each of well...
For patients who have lost sensory function due to a neurological injury such as spinal cord (SCI), stroke, or amputation, stimulation (SCS) may provide mechanism for restoring somatic sensations via an intuitive, non-visual pathway. Inspired by this vision, here we trained rhesus monkeys and rats detect discriminate patterns of epidural SCS. Thereafter, constructed psychometric curves describing the relationship between different SCS parameters animal's ability and/or changes in its...
This study identified a clinically significant subset of patients with glioma tumor outside contrast enhancement present at autopsy and subsequently developed method for detecting nonenhancing using radio-pathomic mapping. We tested the hypothesis that autopsy-based probability maps would be able to noninvasively identify areas infiltrative beyond traditional imaging signatures.
Certain intrauterine risk factors are known to increase the of premature cranial suture fusion and may cause complications during birth. Some these be modifiable. Therefore, authors sought characterize institutional patterns prenatal perinatal in nonsyndromic craniosynostosis patients compared normal births from surrounding area identify areas for possible intervention or prevention.The medical records all infants with full birth born at Duke University Health System 2006 2017 were...