A5005244375- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Nasal Surgery and Airway Studies
- Tracheal and airway disorders
- Delphi Technique in Research
- Bone Tissue Engineering Materials
- Congenital Anomalies and Fetal Surgery
- Surgical Simulation and Training
- Mesenchymal stem cell research
- Obstructive Sleep Apnea Research
- Cardiac, Anesthesia and Surgical Outcomes
- Facial Trauma and Fracture Management
- Gallbladder and Bile Duct Disorders
- dental development and anomalies
- Diversity and Career in Medicine
- Biomedical Ethics and Regulation
- Dental Education, Practice, Research
- 3D Printing in Biomedical Research
- Global Health and Surgery
- Reconstructive Surgery and Microvascular Techniques
- Medical Coding and Health Information
- Bone Metabolism and Diseases
- Genetics and Neurodevelopmental Disorders
- Minimally Invasive Surgical Techniques
- Head and Neck Cancer Studies
Duke Children's Hospital & Health Center
2015-2025
Duke University Hospital
2016-2025
Duke University Health System
2022-2025
Duke Medical Center
2016-2025
Duke University
2015-2024
Creative Commons
2016-2023
Durham Technical Community College
2016-2021
Boston Children's Hospital
2018-2021
Harvard University
2018-2021
Dallas Plastic Surgery Institute
2020
Cleft lip and/or palate (CL/P) is phenotypically diverse, making classification difficult. This article explores the evolution of ideas regarding CL/P and includes schemes described by Davis Ritchie (1922) , Brophy (1923) Veau (1931) Fogh-Andersen (1943), Kernahan Stark (1958) Harkins et al. (1962) Broadbent (1968), Spina (1973) others. Based on these systems, a longhand structured form proposed for describing in way that clear, comprehensive, consistent. A complementary shorthand notation...
Care of the patient with cleft lip and/or palate remains complex. Prior attempts at aggregating data to study effectiveness specific interventions or overall treatment protocols have been hindered by a lack standards. There exists critical need better define outcomes-particularly those that matter most patients and their families-and standardize methods which these outcomes will be measured. This report summarizes recommendations an international, multidisciplinary working group regard...
Learning Objectives: After reading this article, the participant should be able to: 1. Understand components of unilateral and bilateral cleft lip nasal deformity. 2. Assess 3. Design a treatment plan for secondary correction 4. Discuss methods managing suboptimal outcomes. Summary: Correction deformity has been addressed in Maintenance Certification/Continuing Medical Education series number times—a testament to complexity topic. In addition series, authors provide principle-based approach...
Background: As the U.S. population ages and life expectancy increases, number of elderly patients seeking trauma care treatment for facial fractures will increase. Understanding age-related differences in pattern, cause, management these is essential improving care. Methods: A retrospective review adults presenting to a Level I center was performed evaluate fractures. Descriptive statistics were used compare fracture number, type, cause injury, management, adverse events between (older than...
Background . Bone engineering requires thicker three‐dimensional constructs than the maximum thickness supported by standard cell‐culture techniques (2 mm). A flow‐perfusion bioreactor was developed to provide chemotransportation thick (6 mm) scaffolds. Methods Polyurethane scaffolds, seeded with murine preosteoblasts, were loaded into a novel bioreactor. Control scaffolds remained in static culture. Samples harvested at days 2, 4, 6, and 8 analyzed for cellular distribution, viability,...
After reading this article, the participant should be able to: 1. Understand principles of contemporary methods for repair unilateral and bilateral cleft lip. 2. design elements a poor that predispose to suboptimal outcome.The authors describe evaluation management lip (with or without alveolus with palate). Each deformity is presented in "principles-based" manner. For lip, discuss common modifications rotation-advancement Fisher's anatomical subunit approach. In expert hands, both...
Objective: To evaluate the feasibility of using National Patient-Centered Clinical Research Network (PCORnet ® ) as a source electronic health record (EHR) data for cleft outcomes research. Design: Exploratory retrospective analysis multi-year, administrative and clinical, structured stored in PCORnet. Setting: Academic institution with an ACPA-approved craniofacial team. Patients/Participants: Encounter-level pertaining to patients orofacial clefts treated at this center between 2010 2018....
Background Surgical intervention for metopic synostosis is largely based on a subjective impression of the presence and severity trigonocephaly. Several objective methods have been proposed to characterize phenotypic severity, but these are imprecise or impractical. The purpose this investigation was develop practical reliable quantitative method assess trigonocephaly using computed tomographic (CT) data. Methods Clinical administrative databases were queried identify sequential patients...
Optimization of care to correct the unilateral cleft lip nasal deformity is hampered by lack objective measures quantify preoperative severity and outcome. The purpose this study was develop a consensus standard appearance using three-dimensional stereophotogrammetry; determine whether anthropometric measurements could be used outcome; predicts postoperative authors collected facial images 100 subjects in three groups: 45 infants before repair; same after children aged 8 10 years with...
Background: The purpose of this study was to evaluate the utility a previously validated interfrontal angle for classification severity metopic synostosis and as an aid operative decision-making. Methods: An expert panel asked 30 cases ranging from minor severe synostosis. Based on computed tomographic images skull clinical photographs, they classified trigonocephaly (1 = normal, 2 mild, 3 moderate, 4 severe) management (0 nonoperative 1 operative). scores reported by experts were then...
Background: Impaired diabetic wound healing is due, in part, to defects mesenchymal progenitor cell tracking. Theoretically, these may be overcome by administering purified cells directly the wound. The authors hypothesize that will differentiate into endothelial cells, increase vascularity, and improve healing. Methods: Lineage-negative were isolated from wild-type murine bone marrow magnetic sorting, suspended a collagen matrix, applied topically full-thickness excisional dorsal cutaneous...
Background: Despite technical advancement, treatment of congenital alveolar clefts has remained controversial. Currently, primary cleft repair (i.e., gingivoperiosteoplasty) a 41 to 73 percent success rate. However, the remaining patients have persistent bone defects requiring secondary grafting procedures. Morbidity procedures includes pain, graft resorption, extrusion or infection, and tooth loss. The authors present novel rat defect model designed facilitate investigation therapeutics...
Background: Clefts of the lip and/or palate (CL/P) carry a social stigma that often causes psychosocial stress. The purpose this study was to consider association cleft phenotype and age with self-reported aspects Methods: Children nonsyndromic CL/P unaffected children born between 1997 2003 were identified through North Carolina Birth Defects Monitoring Program birth records, respectively. concerns assessed via 29-question subset larger survey. Responses analyzed according school (cleft...
Pediatric temporomandibular joint dysfunction, resulting from either soft-tissue or skeletal disorders, may be congenital acquired. Congenital disorders are uncommon. The authors review their experience with pediatric and propose a new classification system.Clinical records, cephalograms, computed tomographic scans, magnetic resonance images, pathologic specimens of all patients (younger than 18 years) trismus restricted mandibular excursion 1976 to 2008 were reviewed. Cases stratified...
Background: Although bone repair is a relatively efficient process, significant portion of patients fail to heal their fractures. Because adequate blood supply essential osteogenesis, the authors hypothesize that augmenting neovascularization by increasing number circulating progenitor cells will improve bony healing. Methods: Bilateral full-thickness defects were created in parietal bones C57 wild-type mice. Intraperitoneal AMD3100 (n = 33) or sterile saline was administered daily beginning...
Background: The aesthetic aspects of the cleft lip nasal deformity have been appreciated for over a century, but functional implications remained largely underappreciated or misunderstood. This study describes frequency and severity obstructive symptoms among children with and/or palate, addressing hypotheses that age, type, are associated development symptoms. Methods: Children nonsyndromic palate comparison group unaffected born from 1997 to 2003 were identified through North Carolina...