Cannabinoids are natural or synthetic compounds related chemically to (−)-(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol (Δ9-THC), the principle psychotropic constituent of hemp plant, Cannabis sativa L. Here we examine effects cannabinoids Δ9-THC, (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo [1,2,3-de]-1,4-benzoxazin-6-yl]-1-napthalenylmethanone and 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl) cyclohexyl]-5-(2-methyloctan-2-yl)phenol,...

Abstract Butea monosperma is one of the extensively used plants in traditional system medicines for many therapeutic purposes. In this study, antioxidant activity, α -glucosidase and -amylase inhibition properties freeze drying assisted ultrasonicated leaf extracts (hydro-ethanolic) B. have been investigated. The findings revealed that 60% ethanolic fraction exhibited high phenolic contents, total flavonoid highest promising inhibitions. UHPLC-QTOF-MS/MS analysis indicated presence notable...

The naturopathic treatment of obesity is a matter keen interest to develop efficient natural pharmacological routes for disease management with low or negligible toxicity and side effects. For this purpose, optimized ultrasonicated hydroethanolic extracts Taraxacum officinale were evaluated antiobesity attributes. 2,2-diphenyl-1-picrylhydrazyl method was adopted evaluate antioxidant potential. Porcine pancreatic lipase inhibitory assay conducted assess the in vitro property. Ultra-high...

Andrographis paniculata is an annual herb and widely cultivated in Southeast Asian countries for its medicinal use. In recent investigations, A. was found to be effective against Type 1 diabetes mellitus (Type DM). Here, we used a non-genetic out-bred Sprague-Dawley rat model test the antidiabetic activity of 2 Proton Nuclear Magnetic Resonance (¹H-NMR) spectroscopy combination with multivariate data analyses evaluate metformin induced metabolic effects on obese obese-diabetic (obdb) models....

Zanthoxylum rhetsa is an aromatic tree, known vernacularly as "Indian Prickly Ash". It has been predominantly used by Indian tribes for the treatment of many infirmities like diabetes, inflammation, rheumatism, toothache and diarrhea. In this study, we identified major volatile constituents present in different solvent fractions Z. bark using GC-MS analysis isolated two tetrahydrofuran lignans (yangambin kobusin), a berberine alkaloid (columbamine) triterpenoid (lupeol) from bioactive...

Pepsin enzyme was used to pretreat the bovine skin at rate of 5, 15, and 25 units enzyme/g recover gelatin, recovered gelatins were referred as Pe5, Pe15, Pe25, respectively. The gelatin yield increased significantly (p < 0.05) from 18.17% for Pe5 24.67% Pe25 level pepsin increased, but corresponding gel strength viscosity decreased 215.49 56.06 g 9.17 8.17 mPa·s β- α1- α2-chains degraded entirely in all samples observed protein pattern elaborated by electrophoresis. 1H nuclear magnetic...

Meat is a rich source of energy that provides high-value animal protein, fats, vitamins, minerals and trace amounts carbohydrates. Globally, different types meats are consumed to fulfill nutritional requirements. However, the increasing burden on livestock industry has triggered mixing high-price meat species with low-quality/-price meat. This work aimed differentiate samples basis metabolites. The metabolic difference between various was investigated through Nuclear Magnetic Resonance...

Diabetes mellitus type II (DMT-2) is a widely spread metabolic disorder both in developed and developing countries. The role of oxidative stress well established DMT-2 pathogenesis. synthetic drugs for are associated with serious side complications. Antioxidant α-glucosidase inhibitory actions phytochemicals from various plant species considered as an alternative to management. present study aimed evaluate the antioxidant activity, potential phytochemical profiling Hyophorbe lagenicaulis.The...

The use of antioxidant-rich medicinal plants having the potential to reduce oxidative stress and postprandial hyperglycemic pressure is one most promising option for management diabetes. This study presents information on metabolite profiling in vitro anti-diabetic effects leaf extracts Ficus benjamina. DPPH (2, 2-diphenyl-1-picrylhydrazyl radicals) assay was performed determine antioxidant plant extracts. were investigated by evaluating inhibitory properties F. benjamina towards...

Water pollution is an alarming and critical environmental challenge that demands immediate attention. In addition to this, the world also facing energy crisis of ever-increasing proportions. Managing these issues through a sustainable approach need hour. this context, microbial fuel cell (MFC) technology, with its dual capability treat wastewater simultaneous power generation, gaining recognition as solution. The current study was designed evaluate impact modified MFC anode, i.e.,...

The antiphoto aging property of Zanthoxylum rhetsa obtained from Pangkor Island, Malaysia, was evaluated. Solvent fractions different polarity the methanolic extract bark material were initially tested for anticollagenase and antielastase activities. ethyl acetate fraction showed bioactivity against protease enzymes. Hence, it subjected to further purification via column chromatography, yield a major constituent, hesperidin. Subsequently, hesperidin their effects UVB‐induced cytotoxicity...

Gaharu (agarwood, Aquilaria malaccensis Lamk.) is a valuable tropical rainforest product traded internationally for its distinctive fragrance. It not only popular as incense and in perfumery, but also favored traditional medicine due to sedative, carminative, cardioprotective analgesic effects. The current study addresses the chemical differences similarities between gaharu samples of different grades, obtained commercially, using ¹H-NMR-based metabolomics. Two classification models: partial...

The present work was aimed at investigating hydroethanolic leaf extracts of Cassia fistula for their antioxidant and pancreatic lipase (PL) enzyme inhibitory properties. most active extract selected to profile the phytoconstituents by UHPLC-QTOF-MS/MS technique. Among tested extracts, 80% exhibited maximum levels total phenolic flavonoid contents (TPC TFC) with a contribution 201.3 ± 2.6 mg gallic acid equivalent per gram (GAE/g extract), 116.3 2.4 rutin (RE/g respectively. same also showed...

In recent years, medicinal plants have gained much attention as potential source of bioactives for the development novel herbal drugs primary healthcare. However, phytotherapeutic mechanisms action phytomedicines need to be explored comprehensively. Out available strategies said purpose, metabolomics is one, which results in production inclusive metabolite profiles providing a clear understanding diagnostic changes levels metabolites, leading therapeutic monitoring drug targets through...

The supplementation of rumen bypass fat (RBF) has remained one the preferred approaches used to decrease undesirable saturated fatty acids (FA) and increase beneficial unsaturated FA in meat. This study was planned evaluate influences fats on meat quality, acid metabolic profiles male Dorper sheep (n = 36) with 24.66 ± 0.76 kg (mean standard error) initial body weight. Treatment comprised a basal diet (30:70 rice straw concentrate) no added RBF as control (CON), prilled (PF), plus lecithin...

Zebrafish is a frequently employed model organism in systems medicine and biomarker discovery. A crosscutting fundamental question, one that has been overlooked the field, "system-wide" (omics) effects induced zebrafish by metabolic solvents culture buffers. Indeed, any bioactivity or toxicity test requires target compounds are dissolved an appropriate nonpolar solvent aqueous media. It important to know whether buffer itself effect on organism. We evaluated of two organic carrier used...

The microbial biotransformation of Delta(9)-tetrahydrocannabinol was investigated using a collection 206 alkane-degrading strains. Fifteen percent these strains, mainly gram-positive strains from the genera Rhodococcus, Mycobacterium, Gordonia, and Dietzia, yielded more-polar derivatives. Eight derivatives were produced on mg scale, isolated, purified, their chemical structures elucidated with use liquid chromatography-mass spectrometry, (1)H-nuclear magnetic resonance (1H-NMR),...