A5091101314- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Retinoids in leukemia and cellular processes
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- T-cell and Retrovirus Studies
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Hemoglobinopathies and Related Disorders
- Circular RNAs in diseases
- Blood disorders and treatments
- Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Mycobacterium research and diagnosis
- Blood groups and transfusion
- T-cell and B-cell Immunology
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- RNA Interference and Gene Delivery
- COVID-19 Clinical Research Studies
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Antioxidant Activity and Oxidative Stress
Grupo Hospitalar Conceição
2021-2023
Universidade de São Paulo
2006-2015
Clinics Hospital of Ribeirão Preto
2015
Institute for Stem Cell Biology and Regenerative Medicine
2011
Fundação Pró-Sangue Hemocentro de São Paulo
2008
Universidade de Ribeirão Preto
2007
Loss-of-function mutations in telomerase complex genes can cause bone marrow failure, dyskeratosis congenita, and acquired aplastic anemia, both diseases that predispose to acute myeloid leukemia. Loss of function produces short telomeres, potentially resulting chromosome recombination, end-to-end fusion, recognition as damaged DNA. We investigated whether also occur screened samples from 133 consecutive patients with leukemia 198 controls for variations TERT TERC genes. An additional 89 a...
Abstract Background: The most primitive leukemic precursor in acute myeloid leukemia (AML) is thought to be the stem cell (LSC), which retains properties of self‐renewal and high proliferative capacity quiescence hematopoietic cell. LSC seems immunophenotypically distinct more resistant chemotherapy than committed blasts. Considering that multidrug resistance (MDR) constitutive expression may a barrier therapy AML, we have investigated whether various MDR transporters were differentially...
CD56 expression has been associated with a poor prognosis in lymphoid neoplasms, including T-cell acute lymphoblastic leukemia (T-ALL). MicroRNAs (miRNAs) play an important role differentiation, and aberrant miRNA treatment outcome malignancies. Here, we evaluated profiles normal thymocytes, mature T-cells, T-ALL samples without correlated microRNA outcome.The gene profile of 164 miRNAs were compared for T-ALL/CD56+ (n=12) T-ALL/CD56- (n=36) patients by Real-Time Quantitative PCR. Based on...
Recent evidence has shown that deregulated expression of members the micro RNA ‐29 (miR‐29) family may play a critical role in human cancer, including hematological malignancies. However, roles miR‐29 molecular pathophysiology T‐cell acute lymphoblastic leukemia (T‐ ALL ) not been investigated. Here, we show lower levels miR‐29a were significantly associated with higher blast counts bone marrow and increased disease‐free survival T‐ patients. Furthermore, are extremely reduced cells compared...
Some cases of T-cell acute lymphoblastic leukaemia (ALL) express markers found in natural-killer (NK) cells, such as CD56 and CD16. Out 84 ALL diagnosed at our Institution, and/or CD16 was detected 24 (28.5%), which we designated T/NK-ALL group. Clinical features, laboratory characteristics, survival expression cytotoxic molecules were compared T-ALL patients. Significant differences observed regarding age (24.9 vs. 16.4 years T-ALL, respectively, P = 0.006) platelet counts (177 x 10(9)/l 75...
Abstract The use of all trans-retinoic acid (ATRA) is the basis treatment acute promyelocytic leukemia (APL) and represents paradigm differentiation therapy. In general, ATRA well-tolerated but may be associated with a potentially lethal side-effect, referred to as retinoic or syndrome (DS). cellular molecular mechanisms DS are poorly understood involve changes in adhesive qualities cytokine secretion leukemic cells during ATRA-induced differentiation. As leukocyte extravasation key event...
Abstract Background The novel coronavirus disease‐2019 (COVID‐19) caused a sudden and unexpected increase in the number of hospital admissions deaths worldwide. impact social distancing on blood stocks was significant. Data use products by patients with COVID‐19 are scarce. Material methods A retrospective observational study conducted analysing medical records 3014 hospitalized 16 Brazilian hospitals. Individual data related to clinical, laboratory transfusion characteristics outcomes these...
Os plasmócitos normais podem ser diferenciados dos presentes no mieloma múltiplo por imunofenotipagem. são CD45+, CD19+, CD20+, CD38++, CD56-/fraco, CD138+, mIg-, cIg policlonal. Por outro lado, os do monoclonais (cIg) e aproximadamente 80% CD19-CD56+ 20% CD19-CD56-. O perfil na leucemia plasmocitária primária é semelhante ao mieloma, embora a positividade para o CD56 ocorra em 45% casos. Na gamopatia monoclonal de causa indeterminada existe uma mistura neoplásicos, que têm múltiplo. A...
Abstract Background and Objectives Gerbich (GE) blood group system carries high‐frequency antigens the absence of them leads to rare phenotypes: GE:−2,3,4, GE:−2,−3,4 GE:−2,−3,−4. Their serological differentiation is limited misclassification phenotypes may occur, but this can be avoided by molecular characterization. This study aimed characterize background responsible for in Brazilian population. Materials Methods We selected eight samples from patients with anti‐Ge, six their relatives...