A5024257457- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Biosensors and Analytical Detection
- COVID-19 diagnosis using AI
- Bacteriophages and microbial interactions
- Viral Infections and Immunology Research
- HIV Research and Treatment
- Animal Disease Management and Epidemiology
- Advanced biosensing and bioanalysis techniques
- HIV/AIDS drug development and treatment
- Respiratory viral infections research
- Child Nutrition and Water Access
- Leptospirosis research and findings
- Membrane Separation Technologies
- Anomaly Detection Techniques and Applications
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Virology and Viral Diseases
- HIV/AIDS Research and Interventions
- Water Systems and Optimization
- Fecal contamination and water quality
- Orthopedic Infections and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Virus-based gene therapy research
Eau de Paris (France)
2014-2025
Groupe Lépine (France)
2024
Deleted Institution
2022
Inserm
2005-2009
Université Paris Cité
2006-2009
Délégation Paris 7
2006-2009
Hôpital Saint-Louis
2009
Université Claude Bernard Lyon 1
2005
Hôpital Bichat-Claude-Bernard
2005
IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of disease (COVID-19). People infected with SARS-CoV-2 may exhibit no or mild non-specific symptoms; thus, they contribute to silent circulation virus among humans. Since RNA can be detected in stool samples, monitoring waste water (WW) has been proposed as a complementary tool investigate human populations.AimTo test if quantification genomes WW correlates number symptomatic non-symptomatic...
Summary SARS-CoV-2 is the etiological agent of COVID-19. Most carriers are assumed to exhibit no or mild non-specific symptoms. Thus, they may contribute rapid and mostly silent circulation virus among humans. Since can be detected in stool samples it has recently been proposed monitor wastewaters (WW) as a complementary tool investigate human populations. In present work we that quantification genomes should correlate with number symptomatic non-symptomatic carriers. To test this...
Since the beginning of Coronavirus Disease-19 (COVID-19) pandemic, multiple Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) mutations have been reported and led to emergence variants concern (VOC) with increased transmissibility, virulence or immune escape. In parallel, observation viral fecal shedding quantification SARS-CoV-2 genomes in wastewater, providing information about dynamics infections within a population including symptomatic asymptomatic individuals. Here, we aimed adapt...
The major role of the neuraminidase (NA) protein influenza A virus is related to its sialidase activity, which disrupts interaction between envelope hemagglutinin (HA) and sialic acid receptors expressed at surface infected cells. This enzymatic activity known promote release spread progeny viral particles following their production by cells, but a potential NA in earlier steps life cycle has never been clearly demonstrated. In this study we have examined impact expression on HA-mediated...
Since many infected people experience no or few symptoms, the SARS-CoV-2 epidemic is frequently monitored through massive virus testing of population, an approach that may be biased and difficult to sustain in low-income countries. RNA can detected stool samples, quantifying genome by RT-qPCR wastewater treatment plants (WWTPs) has been carried out as a complementary tool monitor circulation among human populations. However, measuring viral load WWTPs affected experimental environmental...
A monkeypox virus outbreak has been spreading in multiple nonendemic countries since May 2022. The atypical clinical profile of patients led to a very likely underestimation the number cases at beginning epidemic. detection and quantification Monkeypox genome sewersheds Paris (France) correlated temporally with identification first case infection spread disease within population connected sewage system.
Although clinical epidemiology lists human enteric viruses to be among the primary causes of acute gastroenteritis in population, their circulation environment remains poorly investigated. These are excreted by population into sewers and may released rivers through effluents wastewater treatment plants (WWTPs). In order evaluate viral diversity loads WWTP Paris, France, urban area, which includes about 9 million inhabitants (approximately 15% French population), seasonal occurrence...
This study examines the impact of water produced by membrane processes on bacterial dynamics within drinking distribution systems. Employing a closed-loop pilot plant designed to replicate real-world conditions, research focused two primary objectives. First, it assessed effects different compositions, which vary in their nutrient concentrations, including tap water, softened ultrafiltered and low-pressure reverse osmosis (LPRO) development pipes over successive 30-day phases. The findings...
Although the interaction between phages and bacteria has already been well described, it only recently emerged that human viruses also interact with in mammalian gut. We studied whether this could occur tap water thus confer enteric protection against temperature classical disinfection treatments used drinking production. demonstrated addition of lipopolysaccharide or peptidoglycan bacterial origin to enterovirus provides thermal through stabilization viral capsid. This plays a role when are...
People infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shed the virus and its genetic material via their sputum, nasopharyngeal secretions, saliva, urine feces (Cevik et al.2021). Hence, public health water quality scientists throughout world have been monitoring untreated and/or primary treated wastewater sludge for surveillance of SARS-CoV-2 in communities (https://arcg.is/1aummW). Numerous reviews discussed possibility transmission to humans from exposure or...
Recent studies have shown that passive sampling is a promising tool for SARS-CoV-2 detection wastewater-based epidemiology (WBE) application. We previously developed of viruses using polymer membranes in seawater. Even though was not detected yet seawater, could be optimized future application coastal areas close to wastewater treatment plant (WWTP). The aim this study optimize sewage and seawater by selecting suitable membrane, determine whether the quantities virus increase over time, then...
Swine acute diarrhoea syndrome coronavirus (SADS-CoV; Coronaviridae, Rhinacovirus) was detected in 2017 Guangdong Province (China), where it caused high mortality rates piglets. According to previous studies, SADS-CoV evolved from horseshoe bat reservoirs. Here, we report the first five Rhinacovirus genomes sequenced bats Vietnam and their comparisons with data published China. Our phylogenetic analyses provided evidence for four groups: rhinacoviruses Rhinolphus pusillus bats, including one...
Abstract Since the end of 2020, COVID-19 pandemic has experienced a major turning point with appearance and rapid spread new variants, causing significant increase in number cases requiring hospitalization. These so-called UK, South African or Brazilian variants are characterized by combinations mutations which allow them to be distinguished from have circulated since start epidemic. The impact these on functioning healthcare systems requires monitoring more contagious, lethal may reinfect...
A sentinel network, Obépine , has been designed to monitor SARS-CoV-2 viral load in wastewaters arriving at wastewater treatment plants (WWTPs) France as an indirect macro-epidemiological parameter. The sources of uncertainty such a monitoring system are numerous, and the concentration measurements it provides left-censored contain outliers, which biases results usual smoothing methods. Hence, need for adapted pre-processing order evaluate real daily amount viruses each WWTP. We propose...
Abstract Previous studies on horseshoe bats ( Rhinolophus spp .) have described many coronaviruses related to SARS-CoV (SARSCoVr) in China and only a few SARS-CoV-2 SARSCoV2r ) Yunnan, Cambodia, Laos Thailand. Here, we report the results of several field missions carried out 2017, 2021 2022 across Vietnam during which 1,218 were sampled. We assemble 38 Sarbecovirus genomes: 26 SARSCoVr from R. thomasi ; six four affinis two recombinants pusillus , one showing receptor-binding domain Spike...
Abstract The ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has been a public health emergency international concern. Although SARS-CoV-2 is considered to be mainly transmitted inhalation contaminated droplets and aerosols, also detected in human feces raw wastewaters suggesting that other routes infection may exist. Monitoring genomes proposed as complementary approach for tracing the dynamics virus transmission...