A5025585597- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- Pancreatic and Hepatic Oncology Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Food Security and Health in Diverse Populations
- Platelet Disorders and Treatments
- Polyomavirus and related diseases
- vaccines and immunoinformatics approaches
- Cancer Genomics and Diagnostics
- COVID-19 Impact on Reproduction
- Blood disorders and treatments
- Salmonella and Campylobacter epidemiology
- Periodontal Regeneration and Treatments
- HIV Research and Treatment
- Escherichia coli research studies
- Health disparities and outcomes
Navarrabiomed
2013-2018
Complejo Hospitalario de Navarra
2018
Universidad Publica de Navarra
2018
Navarre Institute of Health Research
2018
Chartered Institute of Management Accountants
2012
Universidad de Navarra
2007-2011
The mechanisms that underlie the potent Th1-adjuvant capacity of poly(methyl vinyl ether-co-maleic anhydride) nanoparticles (NPs) were investigated. Traditionally, polymer NPs have been considered delivery systems promote a closer interaction between antigen and antigen-presenting cells (APCs). Our results revealed poly(anhydride) also act as agonists various Toll-like receptors (TLRs) (TLR2, -4, -5), triggering Th1-profile cytokine release (gamma interferon [IFN-gamma], 478 pg/ml versus...
Abstract Vaccination strategies based on the in vivo targeting of Ags to dendritic cells (DCs) are needed improve induction specific T cell immunity against tumors and infectious agents. In this study, we have used a recombinant protein encompassing extra domain A from fibronectin (EDA), an endogenous ligand for TLR4, deliver TLR4-expressing DC. The purified EDA was shown bind HEK293 activate TLR4 signaling pathway. also stimulated production by DC proinflammatory cytokines such as IL-12 or...
Low antigen expression and an absence of coimmunostimulatory signals may be partly responsible for the low immunogenicity many tumors. It possible to overcome this situation by defining a combination adjuvants antigens that can activate high-avidity antitumor response. Using poorly immunogenic B16-OVA melanoma cells as tumor model, we tested different combinations treat established In exogenous antigens, repeated administration TLR7 ligand Imiquimod together with anti-CD40 agonistic...
The effects of housing instability and homelessness on child adult health are well documented. However, few studies have explored interventions for families with children the objective improvement. Housing Prescriptions as Health Care is a randomized controlled trial that investigating impact physical mental integrating priority placement in affordable provision services (case management, financial, legal), compared to standard care (providing resource guides hospital-based social work or...
Cervical carcinoma is one of the most common cancers in women worldwide. It well established that chronic infection genital tract by various mucosatropic human papillomavirus (HPV) types causes cervical cancer. Cellular immunity to E7 protein from HPV (HPVE7) has been associated with clinical and cytologic resolution HPV-induced lesions. Thus, we decided test if targeting HPVE7 dendritic cells using a fusion containing extra domain A (EDA) fibronectin, natural ligand for TLR4, (EDA-HPVE7)...
Peripheral blood progenitor cells (PBPCs) have become the major source of hematopoietic for allogeneic transplantation. In February 2008, Zarzio® was approved by European Medicine Agency PBPCs mobilization, but this authorization not based in trials analyzing safety and efficacy mobilization. Since August 2011, has been used at our institution total 36 healthy family donors underwent 18 with Neupogen® Zarzio®. Donor characteristics were equivalent between groups, no severe adverse effects...
The use of preemptive antiviral therapy to prevent cytomegalovirus (CMV) disease in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients might result over-treatment, inducing drug-related toxicity and viral resistance. A search for predictive markers is needed determine requirement therapy. Clinical follow-up, combination with the streptamers (STs) cytokine-intracellular staining, could help identify patients at high risk CMV reactivations. To study immune response...
Multimer technology is widely used to screen antigen-specific immune recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) as it enables identification, enumeration, phenotypic characterization and isolation of virus-specific T-cells. Novel approaches multimerization might improve on classical tetramer staining; however, their use standard monitoring technique quantify cells has not been validated yet. We have compared two these available multimeric complexes:...
Abstract The Extradomain A from fibronectin (EDA) has an immunomodulatory role as fusion protein with viral and tumor antigens, but its effect when administered bacteria not been assessed. Here, we investigated the adjuvant of EDA in mice immunizations against Salmonella enterica subspecies serovar Enteritidis ( Enteritidis). Since lipopolysaccharide (LPS) is a major virulence factor LPS O-polysaccharide (O-PS) immunodominant antigen serological diagnostic tests, mutants lacking O-PS (rough...
Adoptive transfer of CMV-specific T cells has shown promising results in preventing pathological effects caused by opportunistic CMV infection immunocompromised patients following allogeneic hematopoietic stem cell transplantation. The majority studies have used steady-state leukapheresis for CMV-reactive product manufacture, a collection obtained prior to or months after G-CSF mobilization, but the procurement this additional sample is often not available unrelated donor setting. If...
Cytomegalovirus (CMV)-specific T cell infusion to immunocompromised patients following allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) is able induce a successful anti-viral response. These cells have classically been manufactured from steady-state apheresis samples collected the donor in an additional harvest prior G-CSF mobilization, treatment that induces hematopoietic stem (HSC) mobilization periphery. However, two closely-timed cellular collections are not usually...
Multiple myeloma (MM) is a very heterogeneous disease, characterized by multiple cytogenetic aberrations on plasma cells (PC) that have been traditionally used to predict the outcome of disease. A mayor issue analysis PC sometimes low infiltration these in bone marrow hampers studies. To solve this problem we optimized selection strategy based immunomagnetic isolation has allowed us lower 1% minimal requirement without loss purity, enabling perform genetic analysis. In study, analyzed 153...
<div>Abstract<p>Low antigen expression and an absence of coimmunostimulatory signals may be partly responsible for the low immunogenicity many tumors. It possible to overcome this situation by defining a combination adjuvants antigens that can activate high-avidity antitumor response. Using poorly immunogenic B16-OVA melanoma cells as tumor model, we tested different combinations treat established In exogenous antigens, repeated administration TLR7 ligand Imiquimod together with...
Supplementary Figures 1-8, Table 1 from Adjuvant Combination and Antigen Targeting as a Strategy to Induce Polyfunctional High-Avidity T-Cell Responses against Poorly Immunogenic Tumors