A5035690221- Essential Oils and Antimicrobial Activity
- Head and Neck Cancer Studies
- Electrospun Nanofibers in Biomedical Applications
- Antimicrobial agents and applications
- Antifungal resistance and susceptibility
- Oral microbiology and periodontitis research
- Sports Performance and Training
- Bone Tissue Engineering Materials
- Medical and Biological Ozone Research
- Hemostasis and retained surgical items
- Laser-Ablation Synthesis of Nanoparticles
- Advanced Drug Delivery Systems
- Head and Neck Surgical Oncology
- RNA modifications and cancer
- Toxin Mechanisms and Immunotoxins
- Dental Radiography and Imaging
- Telecommunications and Broadcasting Technologies
- Dental materials and restorations
- Peer-to-Peer Network Technologies
- Peptidase Inhibition and Analysis
- Oral and Maxillofacial Pathology
- Exercise and Physiological Responses
- Antimicrobial Peptides and Activities
- Wnt/β-catenin signaling in development and cancer
- Trypanosoma species research and implications
Universidade Federal da Paraíba
2011-2024
McGill University
2020-2023
Jewish General Hospital
2020-2023
Universidade Federal de Pernambuco
2019-2022
ORCID
2020
Chitosan is a polysaccharide composed of randomly distributed chains β-(1-4) D-glucosamine and N-acetyl-D-glucosamine. This compound obtained by partial or total deacetylation chitin in acidic solution. The chitosan-based hemostatic agents have been gaining much attention the management bleeding. aim this study was to evaluate vitro hemagglutination activity chitosan nanoparticles using human erythrocytes. preparation achieved ionotropic gelification technique followed neutralization with...
Abstract The gaining popularity of tobacco and nicotine delivery products, such as electronic cigarettes (e-cigarettes) being perceived relatively safe is a medical concern. long-term safety these new products remains uncertain for oral health. In this study, in vitro effects e-liquid were assessed panel normal epithelium cell lines (NOE HMK), squamous carcinoma (OSCC) human (CAL27 HSC3), mouse cancer line (AT84) using proliferation, survival/cell death, invasion assays. addition, signaling...
The present study demonstrates the antifungal potential of chemically characterized essential oil (EO) Cinnamomum zeylanicum Blume on Candida spp. biofilm and establishes its mode action, effect fungal growth kinetics, cytotoxicity to human cells. minimal inhibitory concentration (MIC) fungicidal (MFC) values varied from 62.5 1,000 μg/mL, seems be due interference with cell wall biosynthesis. kinetics assay showed that EO at MICx2 (500 μg/mL) induced a significant (p < 0.05) reduction after...
The aim of this study was to develop polymeric nanofibers for controlled administration Amphotericin B (AmpB), using the solution centrifugation technique, characterizing its microstructural and physical properties, release rate, activity against Leishmania Candida species. core-shell incorporated with AmpB were synthesized by Solution Blow Spinning (SBS) characterized scanning electron microscopy (SEM), differential calorimetry, X-Ray diffraction, drug assay. In vitro leishmanicidal...
We evaluated the antifungal and anti-biofilm activity, mechanism of action cytotoxicity chloramine T trihydrate (CAT) against Candida spp. The Minimum Inhibitory Fungicidal Concentrations (MIC/MFC) CAT were determined. Changes in CAT-treated C. albicans growth kinetics micromorphology evaluated, as well action, its effects on biofilm. Cytotoxicity was assessed by hemolysis method. data analyzed inferential statistics (p ≤ 0.05). showed activity all strains, with MIC values ranging between...
Regional metastasis is the single most important prognostic factor in oral squamous cell carcinoma (OSCC). Abnormal expression of N-myc downstream-regulated genes (NDRGs) has been identified to occur several tumor types and predict poor prognosis. In OSCC, clinical significance deregulated NDRG not fully established. this study, NDRG1 relevance was assessed at gene protein levels 100 OSCC patients followed up by least 10 years. Survival outcome analyzed using a multivariable analysis. Tumor...
The pathogenic nature of infections caused by Candida spp. underscores the necessity for novel therapeutic agents. Extracts Schinopsis brasilienses Engl are \ a promising source agents with antifungal effects. This study aimed to assess potential leaf extract S. brasilienses. activity was evaluated determining minimum inhibitory concentrations and fungicide (MIC MFC). antibiofilm assessed counting colony-forming units/mL. examined inhibition kinetics fungal growth synergism between gallic...
Bioactive glasses (BG) applications include tissue engineering for bone regeneration, coating implants, and scaffolds wound healing. BG can be conjugated to ions like silver, which might add some antimicrobial properties this biomaterial. The immunomodulatory activity of ion-doped bioactive particles was not investigated before. aim work evaluate the cytotoxic effect silver-doped glass (BGAg) in human peripheral blood cells. BGAg samples belonging system 58SiO2•(36-x)CaO·6P2O5·xAg2O, where x...
Objective: To perform chemical analysis and to evaluate the anti-biofilm hemolytic effect of essential oil of Cymbopogon citratus . Material Methods: Gaseous chromatography coupled mass spectrometer was performed for characterization oil. verify antimicrobial action, Minimum Inhibitory Concentration (MIC), Bactericidal (MBC) Fungicidal (MFC) were determined. From MIC, MBC MFC data, concentrations established hemolysis test on human erythrocytes. A multispecies biofilm developed in vitro...
The detection of Leishmania spp. through a disposable surface plasmon resonance (SPR) biochip, using mono- and polychromatic sources, is presented here. A highly specific sensitive-constrained synthetic peptide (LC2) derived from mimotope chagasi antigen was immobilized on the sensing region simple protocol. ELISA- PCR-confirmed negative positive sera infected patients were used. Detection IgG showed fast response with good sensitivity specificity for proposed method.
Papillary thyroid carcinoma (PTC) is the most common malignancy of gland and early stages are curable. However, a subset PTCs shows an unusually aggressive phenotype with extensive lymph node metastasis higher incidence locoregional recurrence. In this study, we investigated large cohort PTC cases unusual using high-throughput RNA sequencing (RNA-Seq) to identify differentially regulated genes associated metastatic PTC. All mutated BRAF (V600E) but not wild-type expressed up-regulation...
Abstract This study aimed to synthesize, characterize, and evaluate the hemagglutinating activity of chitosan sponges (Cs) polycaprolactone nanoparticles transporting tranexamic acid. Sponges were prepared in various concentrations, lyophilized, characterized by Fourier transform infrared spectroscopy, differential scanning calorimeter, thermogravimetric analysis, electron microscopy, zeta potential, profilometry, nuclear magnetic resonance ( 1 H NMR). Samples evaluated for potential...
The aim of this study was to characterize temporal aspects and verify the acute effect a beach volleyball game on testosterone, cortisol T:C ratio in young athletes. Participants were 16 male athletes (age= 17 ± 2,44 years, height= 1,84 0,06 m, body mass 76,23 9,54 kg, BMI 22,35 1,92, number training sessions per week 4 1,20 days). Athletes made match with official rules which filmed for analysis. Saliva used measure testosterone levels testosterone/cortisol (T:C ratio) calculated. Hormonal...
The present study aimed to investigate (i) differences in salivary testosterone and cortisol concentrations before, during, after simulated beach volleyball match, depending on match outcome (winning vs. losing); (ii) the relationship between technical-tactical performance indicators hormonal (i.e., testosterone, cortisol). We hypothesized would be greater winners lower; associate with positive negative performance. Sixteen athletes participated were grouped according result of a game...
O presente estudo teve como objetivos avaliar a prevalência de caninos superiores não irrompidos, suas posições intraósseas e se há relação com idade o gênero. Foram avaliadas 100 radiografias panorâmicas digitais, no período compreendido entre os anos 2009 2010. Para coleta dados foi utilizada uma ficha específica onde registrou idade, gênero posicionamento dos elementos. análise da angulação distância cúspide do canino à crista rebordo alveolar utilizado programa Meazure®. Os resultados...
The aim of this work was to evaluate Morita-Baylis-Hillman adduct (MBHA) antimicrobial effect against oral pathogens and related cell viability in human leukocytes. Minimum inhibitory concentration (MIC) determined using microdilution method. Cell assessed peripheral blood mononuclear cells (PBMCs) the resazurin assay. For S. aureus (ATCC 15656) mutans (UA 159) MIC values 2,000 μg/mL were reported for A 1 adducts. MICs 2 3 adducts not found bacterial strains. 125 μg/mL, 1,000 15.6μg/mL C....