A5021152696- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Cell death mechanisms and regulation
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Systemic Lupus Erythematosus Research
- Complement system in diseases
- Immune Response and Inflammation
- Neurosurgical Procedures and Complications
- S100 Proteins and Annexins
- Vibrio bacteria research studies
- Renal Diseases and Glomerulopathies
- Cerebrospinal fluid and hydrocephalus
- Neurological Disease Mechanisms and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Bone and Joint Diseases
- Organ Transplantation Techniques and Outcomes
- Renal function and acid-base balance
- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Disaster Response and Management
Hospital Universitario de Canarias
2014-2024
Abstract Background Patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular (CV) events and CV mortality. Subclinical carotid atherosclerosis is independently associated rates incident among patients RA. The complement system has been related to both the etiopathogenesis RA disease. In this study, we aimed evaluate association between a comprehensive assessment intima media thickness plaque in Methods 430 were recruited. Functional assays three pathways system,...
Objective Apoptosis is increased in sepsis. Cytokeratin 18 (CK-18), a protein of the intermediate filament group present most epithelial and parenchymal cells, cleaved by action caspases released into blood as caspase-cleaved CK (CCCK)-18 during apoptosis. Circulating levels CCCK-18 have scarcely been explored septic patients. In one study with 101 severe patients, authors reported higher serum non-survivors than survivors; however, sample size was too small to demonstrate an association...
Objective There have been found apoptotic changes in brain tissue samples from animals and humans after a traumatic injury (TBI). The protein cytokeratin 18 (CK-18), present epithelial cells, is cleaved by the action of caspases during apoptosis, resulting fragments are released into blood as caspase-cleaved CK (CCCK)-18. Circulating levels CCCK-18, biomarker determined patients with different processes; however, it has not explored TBI patients. Thus, objective this study was to determine...
To date a complete characterization of the components complement (C) pathways (CLassical, LEctin and ALternative) in patients with systemic lupus erythematosus (SLE) has not been performed. We aimed to assess function these three C cascades through functional assays measurement individual proteins. then studied how they relate clinical characteristics. New generation system were assessed 284 SLE. Linear regression analysis was performed study relationship between activity, severity, damage...
Meta-analysis has found that high baseline red blood cell distribution width (RDW) is associated with increased long-term mortality (mortality at one year or more) in ischemic stroke. The objectives of this study were to determine whether there an association between RDW and 30-day mortality, explore during the first week stroke could be a biomarker.We included patients malignant middle cerebral artery infarction (MMCAI). days 1, 4, 8 MMCAI determined. end-point was mortality.We survivor (n...
Background: There are no data on circulating concentrations of sFas (proapoptotic protein extrinsic pathway) and Bcl2 (antiapoptotic intrinsic in COVID-19 patients. Thus, our objective study was to determine whether an association exists between serum patient mortality.
Background: CD154 and its soluble counterpart (sCD154) are proteins of the tumor necrosis factor (TNF) family exhibit proinflamatory procoagulant properties. Higher circulating sCD154 levels have been found in ischemic stroke patients than controls. However, association between mortality has not reported, was focus this study. Methods: This a multicenter, observational prospective study carried out six Spanish Intensive Care Units. We measured serum from 50 with severe malignant middle...
Background The complement system has been linked to the etiopathogenesis of rheumatoid arthritis (RA). Patients with RA exhibit a dysregulated profile lipid molecules, which attributed inflammation present in disease. In this study, we aimed evaluate association between comprehensive assessment and patients RA. Methods 430 were recruited. New-generation techniques employed conduct functional assays three pathways system. Serum levels various components such as C1q, factor D, properdin,...
The complement (C) system is implicated in the etiopathogenesis of rheumatoid arthritis (RA). However, there a lack studies characterizing all three C pathways RA patients. This study aimed to evaluate association between an in-depth examination and patient characteristics, focusing on disease activity presence factor anti-citrullinated protein autoantibodies (ACPA). In cohort 430 patients, functional assays (classical, alternative, lectin) serum levels their components were assessed....
Transforming growth factor beta (TGF-β) is a highly pleiotropic cytokine that has broad anti-inflammatory and immunosuppressive effects. In patients with systemic lupus erythematosus (SLE), the effect of TGF-β1 thought to be dysfunctional. present work, we aimed study relationship between serum levels characteristics disease as well patterns activity, damage, or severity disease. Two hundred eighty-four well-characterized SLE were recruited. The assessed. A multivariable linear regression...