A5083868937- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- HIV Research and Treatment
- Infrared Thermography in Medicine
- Reproductive System and Pregnancy
- Tendon Structure and Treatment
- Immunotherapy and Immune Responses
- Soil and Water Nutrient Dynamics
- Water Quality and Resources Studies
- Groundwater and Isotope Geochemistry
- Healthcare and Venom Research
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2023
National Institutes of Health
2023
University of Alabama at Birmingham
2017-2022
University of Mississippi Medical Center
2022
Abstract The tetraspanin CD151 is a marker of aggressive cell proliferation and invasiveness for variety cancer types. Given reports expression on T cells, we explored whether would mark cells in hyperactivated state. Consistent with the idea that could phenotypically distinct subset, it was not uniformly expressed cells. frequency function lineage (CD8 > CD4) memory differentiation state (naive < central effector RA+ cells). CD57, senescence marker, defined same CD28−...
Abstract Tetraspanins are a family of proteins with an array functions that well studied in cancer biology, but their importance immunology is underappreciated. Here we establish the tetraspanin CD151 as unique marker T-cell activation and, extension, indicator elevated, systemic activity. Baseline expression found on subset T-cells was indicative increased MAPK pathway. Following TCR/CD3 activation, upregulated overall population, quintessential feature marker. CD151+ frequencies spleen,...
HIV-1 persists in a latent reservoir memory CD4 T cells for the lifetime of patient. Understanding biomolecular mechanisms used by host to suppress viral expression will provide essential insights required develop curative therapeutic interventions.
Abstract We have demonstrated that the tetraspanin CD151 marks a hyperactivated, pro-inflammatory human CD4+ T cell population. Expansion of this population in HIV patients on ART may explain associated risk inflammation-related co-morbidities. However, CD151+ CD4 cells can also proliferate independent cognate antigen recognition, driven by just IL-2, feature is reminiscent latently infected which been reported to maintain latent reservoir size homeostatic proliferation mechanisms. The...
Abstract We recently reported that in humans the tetraspanin CD151 marks phenotypically distinct T cell subsets. The frequency of CD151+ cells differs between lineages and memory populations. are hyper-proliferative hyper-activated, as shown by phospho-proteomic analysis. found is an activation marker upregulated following TCR/CD3 activation, but at baseline, presence was associated with loss CD28 expression, a sign senescence. hypothesized immune hyperactivation extension, impaired...