A5013726300- Immune Cell Function and Interaction
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Malaria Research and Control
- Insect symbiosis and bacterial influences
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Community Health and Development
- vaccines and immunoinformatics approaches
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Cell Adhesion Molecules Research
- CRISPR and Genetic Engineering
- COVID-19 and Mental Health
- Virology and Viral Diseases
- Bacteriophages and microbial interactions
- Youth, Drugs, and Violence
- Immunotherapy and Immune Responses
- Poverty, Education, and Child Welfare
Intarcia Therapeutics (United States)
2023-2025
University of Alabama at Birmingham
2016-2022
Florida Gulf Coast University
2016
For decades, human infections with Zika virus (ZIKV), a mosquito‐transmitted flavivirus, were sporadic, associated mild disease, and went underreported since symptoms similar to other acute febrile diseases. Recent reports of severe disease ZIKV have greatly heightened awareness. It is anticipated that will continue spread in the Americas globally where competent Aedes mosquito vectors are found. Dengue (DENV), most common both well‐established source outbreaks areas recent introduction....
SARS-CoV-2 causes a wide spectrum of clinical manifestations and significant mortality. Studies investigating underlying immune characteristics are needed to understand disease pathogenesis inform vaccine design. In this study, we examined cell subsets in hospitalized nonhospitalized individuals. patients, many adaptive innate cells were decreased frequency compared with those healthy convalescent individuals, the exception an increase B lymphocytes. Our findings show increased frequencies T...
Abstract Background GB-0669 is a novel half-life extended monoclonal antibody for the prophylaxis of SARS-CoV2 infection and one first biologics designed using artificial intelligence/machine learning to reach clinical development against SARS-CoV2. targets previously undruggable S2 domain spike protein, which contains fusion peptide stem-helix peptides, was selected because conserved across all variants to-date. The not immunodominant therefore subject selective pressure from natural or...
Abstract Background The elderly and immunocompromised remain at high risk of severe COVID-19 due to suboptimal immune responses. Monoclonal antibodies SARS-CoV-2 spike were highly effective for both prophylaxis treatment, but quickly became ineffective viral escape. Using a machine learning-guided optimization approach, we identified two against conserved epitopes, one targeting the S2 stem helix (GB-0669) other class 4 RBD site on S1 (PRO-37587) with goal developing combination that would...
Sarbecoviruses, a subgenus of coronaviruses, include strains with zoonotic spillover risk as exemplified by recent outbreaks (SARS-CoV-1, SARS-CoV-2). Monoclonal antibodies targeting conserved spike protein regions (RBD class 4, S2 fusion machinery) exhibit broad sarbecovirus neutralization, but their utility has been impacted immune selection leading to escape and suboptimal neutralization. Using structure-conditioned machine-learning design we optimized two broadly neutralizing rescue the...
Abstract Background For decades, human infections with Zika virus (ZIKV), a mosquito-transmitted flavivirus, were sporadic, associated mild disease, and went underreported since symptoms similar to other acute febrile diseases endemic in the same regions. Recent reports of severe disease ZIKV, including Guillain-Barré syndrome fetal abnormalities, have greatly heightened awareness. Given its recent history rapid spread immune naïve populations, it is anticipated that ZIKV will continue...
ABSTRACT SARS-CoV-2 causes a wide spectrum of clinical manifestations and significant mortality. Studies investigating underlying immune characteristics are needed to understand disease pathogenesis inform vaccine design. In this study, we examined cell subsets in hospitalized non-hospitalized individuals. patients, many adaptive innate cells were decreased frequency compared healthy convalescent individuals, with the exception B lymphocytes which increased. Our findings show increased...
Abstract Tetraspanins are a family of proteins with an array functions that well studied in cancer biology, but their importance immunology is underappreciated. Here we establish the tetraspanin CD151 as unique marker T-cell activation and, extension, indicator elevated, systemic activity. Baseline expression found on subset T-cells was indicative increased MAPK pathway. Following TCR/CD3 activation, upregulated overall population, quintessential feature marker. CD151+ frequencies spleen,...
The biomolecular mechanisms controlling latent HIV-1 infection, despite their importance for the development of a cure are only partially understood. For example, ex vivo studies have recently shown that T cell activation triggered reactivation in fraction latently infected CD4+ reservoir, but molecular biology this phenomenon is unclear. We demonstrate infection primary cells and lines indeed generates substantial amount receptor (TCR)/CD3 activation-inert cells. RNA-level analysis...
HIV-1 persists in a latent reservoir memory CD4 T cells for the lifetime of patient. Understanding biomolecular mechanisms used by host to suppress viral expression will provide essential insights required develop curative therapeutic interventions.
ABSTRACT Although the ability of HIV-1 to reside in a latent state CD4+ T cells constitutes critical hurdle curative therapy, biomolecular mechanisms by which infection is established and maintained are only partially understood. E x vivo studies have shown that cell receptor/CD3 stimulation triggered reactivation fraction latently infected reservoir, suggesting parts population hosting events altered be TCR/CD3-activation-inert. We provide experimental evidence primary lines indeed...
Despite the clinical importance of latent human immunodeficiency virus type 1 (HIV-1) infection, our understanding biomolecular processes involved in HIV-1 latency control is still limited. This study was designed to address whether interactions between viral proteins, specifically HIV Nef, and host cell could affect establishment. The driven by three reported observations. First, early reports suggested that 2 (HIV-2) infection patients produces a lower RNA/DNA ratio than potentially...
Abstract Background The clinical benefit of anti-spike mAbs for prophylaxis and treatment SARS-CoV-2 is now well established (Baum 2020, Loo 2022, Westendorf Jones 2021, Kreuzberger Cathcart Hirsch Shi 2020); However, the evolution SARS CoV-2 due to immune pressure has compromised utility all previously approved which target variable, dominant receptor binding domain Spike protein. Despite success vaccination protecting general population, immunocompromised elderly remain at high risk...