A5084099812- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- COVID-19 and Mental Health
- Immune Cell Function and Interaction
- Microbial infections and disease research
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Vaccine Coverage and Hesitancy
- Immune responses and vaccinations
- Entomopathogenic Microorganisms in Pest Control
- vaccines and immunoinformatics approaches
- Genomics and Chromatin Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Helminth infection and control
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Acute Myeloid Leukemia Research
- Mosquito-borne diseases and control
University of Alabama at Birmingham
2019-2024
Spring Hill College
2016
SARS-CoV-2 causes a wide spectrum of clinical manifestations and significant mortality. Studies investigating underlying immune characteristics are needed to understand disease pathogenesis inform vaccine design. In this study, we examined cell subsets in hospitalized nonhospitalized individuals. patients, many adaptive innate cells were decreased frequency compared with those healthy convalescent individuals, the exception an increase B lymphocytes. Our findings show increased frequencies T...
New therapies for Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) patients are urgently needed. The genetic landscape of Ph-like ALL is characterized by a diverse array kinase-activating alterations (including rearrangements, sequence mutations, and copy number alterations), suggesting that with candidates targeted therapy, similar to BCR-ABL1 ALL. We sought investigate the functional role targetability spectrum identified in demonstrate cytokine-independent growth...
T-cell immunity is likely to play a role in protection against SARS-CoV-2 by helping generate neutralizing antibodies. We longitudinally studied CD4 responses the M, N, and S structural proteins of 26 convalescent individuals. Within first two months following symptom onset, majority individuals (81%) mounted at least one response, 48% detectable SARS-CoV-2-specific circulating T follicular helper cells (cTfh, defined as CXCR5+PD1+ cells). cTfh across all three protein specificities...
A subset of COVID-19 patients exhibit post-acute sequelae (PASC), but little is known about the immune signatures associated with these syndromes. We investigated longitudinal peripheral blood samples in 50 individuals previously confirmed SARS-CoV-2 infection, including 20 who experienced prolonged duration symptoms (lasting more than 30 days; median = 74 days) compared had symptom resolution within days. Individuals maintained antigen-specific T cell response magnitudes to spike protein...
Abstract Background Since the introduction of combination antiretroviral therapy (cART) brain has become an important human immunodeficiency virus (HIV) reservoir due to relatively low penetration many drugs utilized in cART into central nervous system (CNS). Given inherent limitations directly assessing acute HIV infection brains people living with (PLWH), animal models, such as humanized mouse offer most effective means studying effects different viral strains and their impact on CNS. To...
ABSTRACT Mammals express six major somatic linker histone subtypes, all of which display dynamic binding to chromatin, characterized by transient at a given location followed rapid translocation new site. Using photobleaching techniques, we systematically measured the exchange rate mouse H1 subtypes determine their relative chromatin-binding affinity. Two H1.1 and H1.2, affinities that are significantly lower than other subtypes. in vitro mutagenesis, differences between (lower affinity)...
HLA-I-associated human immunodeficiency virus (HIV) adaptation is known to negatively affect disease progression and CD8 T-cell responses. We aimed assess how affects HIV vaccine-induced responses in 2 past vaccine efficacy trials. found that vaccine-encoded adapted epitopes were less immunogenic than nonadapted epitopes, epitope-specific polyfunctional Along those lines, recipients with higher HLA-I the Gag insert mounted at protein level. Breadth of response, which correlated viral control...
Abstract: There is mounting evidence that HIV infection a risk factor for severe presentations of COVID-19. We hypothesized the persistent immune activation associated with chronic contributes to worsened outcomes during acute The goals this study were provide an in-depth analysis response COVID-19 and investigate relationships between responses clinical in unvaccinated, sex- race-matched cohort people (PWH, n = 20) without (PWOH, 41). performed flow cytometric analyses on peripheral blood...
ABSTRACT SARS-CoV-2 causes a wide spectrum of clinical manifestations and significant mortality. Studies investigating underlying immune characteristics are needed to understand disease pathogenesis inform vaccine design. In this study, we examined cell subsets in hospitalized non-hospitalized individuals. patients, many adaptive innate cells were decreased frequency compared healthy convalescent individuals, with the exception B lymphocytes which increased. Our findings show increased...
Abstract T-cell immunity is likely to play a role in protection against SARS-CoV-2 by helping generate neutralizing antibodies. We longitudinally studied CD4 responses the M, N, and S structural proteins of 21 convalescent individuals. Within first two months following symptom onset, majority individuals (81%) mount at least one response, 48% detectable SARS-CoV-2-specific peripheral T follicular helper cells (pTfh, defined as CXCR5 + PD1 cells). pTfh across all three protein specificities...
Despite the well-established contribution of CD8 T cells in HIV control, prior cell-based vaccines have failed to demonstrate any efficacy preventing viral infection. One such vaccine, known as MRKAd5 showed a potential increased risk infection among vaccine recipients.
Epitopes with evidence of HLA-II-associated adaptation induce poorly immunogenic CD4