A5102018504- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Pancreatitis Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Systemic Lupus Erythematosus Research
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Renal Diseases and Glomerulopathies
- Tuberculosis Research and Epidemiology
- Multiple Sclerosis Research Studies
- Cancer-related molecular mechanisms research
- Cardiovascular Syncope and Autonomic Disorders
- Cervical Cancer and HPV Research
- Circadian rhythm and melatonin
- Diagnosis and treatment of tuberculosis
- Microbial bioremediation and biosurfactants
- Protein Degradation and Inhibitors
- DNA and Nucleic Acid Chemistry
- Streptococcal Infections and Treatments
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
Post Graduate Institute of Medical Education and Research
1985-2025
Ahmedabad Civil Hospital
2024
Uttarakhand Open University
2024
Government Medical College and Hospital
2020-2022
Indian Institute of Chemical Biology
2022
University of Alabama at Birmingham
2018-2021
Ann Arbor Center for Independent Living
2020
Royal Liverpool and Broadgreen University Hospital NHS Trust
2019
Panjab University
2011-2016
Texas Woman's University
2014
The acidic microenvironment around tumor cells is a major determinant in cancer growth, metabolism, and metastasis. However, its role physiology still not clearly understood. In the present investigation, an attempt has been made to explore effect of environment on cells. Exposure Raji extracellular was associated with enhanced cytosolic calcium level endoplasmic reticulum stress response. X-box binding protein 1 (XBP1) splicing, CCAAT/enhancer-binding homologous (CHOP), glucose-regulated 78...
Abstract Background Developing a granulomatous liver injury preclinical model may pave the way to understanding hepatic‐TB (tuberculosis) and autoimmune diseases. Antitubercular (ATT) other drugs' metabolism in presence of specific type is not well understood. The present study aimed establish hepatitis by using BCG (Bacillus Calmette‐Guérin) vaccine, further studying it ATT dosing, analyze pharmacokinetics isoniazid, rifampicin, their respective primary metabolites. Methods We used 56 rats...
Abstract Gall bladder cancer (GBC) is common among the socioeconomically deprived populations of certain geographical regions. Aflatoxin a genotoxic hepatocarcinogen, which recognized to have role in pathogenesis hepatocellular carcinoma. However, aflatoxin GBC largely unknown. We determined serum AFB1‐Lys albumin adduct (AAA) levels as marker exposure patients with and compared those without GBC. The relationship AAA cytogenetic (TP53mutation&HER2/neu amplification) radiological...
Signaling through Toll-like receptor-9 (TLR9), a mediator of innate immune responses, could have role in the pathogenesis systemic lupus erythematosus (SLE). Some studies shown an association between polymorphisms TLR9 gene and disease manifestations. We investigated whether two single nucleotide (-1486 T>C +1174 G>A) are associated with risk renal involvement SLE. DNA samples from 112 SLE patients (62 nephritis) 100 healthy controls were obtained. analyzed by polymerase chain...
Abstract This is a joint position statement of the British Society Echocardiography, Heart Valve and for Endocrinology on role echocardiography in monitoring patients receiving dopamine agonist (DA) therapy hyperprolactinaemia. (1) Evidence that DA pharmacotherapy causes abnormal valve morphology dysfunction at doses used management hyperprolactinaemia extremely limited. clinically significant pathology absent, except isolated case reports around which questions remain. (2) Attributing...
Abstract Tetraspanins are a family of proteins with an array functions that well studied in cancer biology, but their importance immunology is underappreciated. Here we establish the tetraspanin CD151 as unique marker T-cell activation and, extension, indicator elevated, systemic activity. Baseline expression found on subset T-cells was indicative increased MAPK pathway. Following TCR/CD3 activation, upregulated overall population, quintessential feature marker. CD151+ frequencies spleen,...
Historically, biophysical studies of nucleic acids have been carried out under near ideal conditions, i.e., low buffer concentration (e.g., 10 mM phosphate), pH 7, ionic strength 100 mM) and, for optical studies, concentrations DNA 1×10⁻⁶ M). Although valuable structural and thermodynamic data come these the most, part, are inadequate to simulate realistic cellular conditions. The increasing interest in studying biomolecules more cellular-like conditions prompted us investigate effect...
We investigated whether a previously reported association of IFNGR expression with rheumatoid arthritis (RA) and its radiographic severity reflects differences in proximal interferon-γ (IFN-γ) signaling T cells from patients RA compared healthy controls (HC).Using phosphoflow cytometry, we IFN-γ-stimulated signal transducer activator transcription 1 (STAT1) activation CD4+ CD8+ T-cell populations HC.Compared controls, had higher proportion cells, associated expansion the effector memory...
Non-small cell lung cancer (NSCLC) has a poor prognosis. Targeted therapy and immunotherapy in recent years significantly improved NSCLC patient outcome. In this study, we employed cell-by-cell immune marker profiling of the primary tumor cells to investigate possible signatures that might predict presence or absence circulating (CTCs). We performed comprehensive study on 10 tissue samples with paired blood samples. The solid biopsy were dissociated into single by non-enzymatic...
Several host genetic factors play an important role in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection and its progression acquired immune deficiency syndrome (AIDS). The interleukin-18 (IL-18) is a multifunctional proinflammatory cytokine that regulates responses plays pathogenic HIV-1 by enhancing viral replication. Single nucleotide polymorphisms (SNPs) the IL-18 gene promoter region may lead altered transcriptional activity production, account for variation risk...
Although ofloxacin-ornidazole fixed-dose combination (FDC) is a rampantly used antibiotic for mixed-infection diarrhea in India, the adverse drug reaction (ADR) associated with these FDCs remains underreported. Herein, authors present case report of definitive FDC-induced pancreatitis. The nonalcoholic adult male patient showed sharp piercing epigastric pain flowing to back, gradually rising severity, which started after taking FDC tablet over counter. Serum lipase concentration measured...
Background: Esophageal variceal bleeding is affected by various risk factors. We hypothesized that increased exposure to gastric acid in patients with abnormal gastroesophageal flap valve (GEFV) might increase esophageal bleeding.
Abstract Managing pancreatic fluid collections (PFCs) in acute pancreatitis has undergone a paradigm shift. Endoscopic and surgical advancements have led to the development of safer more effective techniques for draining PFCs performing necrosectomy. These been effectively incorporated into step-up approach. Percutaneous catheter drainage remains cornerstone managing PFCs, although its role changed with advent endoscopic ultrasound-guided techniques. PFC management relies heavily on...