A5016047586- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- HIV Research and Treatment
- Pancreatitis Pathology and Treatment
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Extracellular vesicles in disease
- Virus-based gene therapy research
- Adipokines, Inflammation, and Metabolic Diseases
- interferon and immune responses
- Viral Infections and Immunology Research
- Viral Infections and Outbreaks Research
- Acute Kidney Injury Research
- Pharmacological Effects of Natural Compounds
- Chronic Kidney Disease and Diabetes
- Invertebrate Immune Response Mechanisms
- COVID-19 Impact on Reproduction
- Computational Drug Discovery Methods
- Liver Disease Diagnosis and Treatment
- Parasites and Host Interactions
- Influenza Virus Research Studies
- Muscle and Compartmental Disorders
- Diabetes and associated disorders
Center for Research and Advanced Studies of the National Polytechnic Institute
2018-2024
Universidad Autónoma Metropolitana
2023-2024
Abstract The Dengue (DENV) and zika (ZIKV) virus infections are currently a public health concern. At present, there is no treatment or safe effective vaccine for these viruses. Hence, the development of new strategies as host-directed therapy required. In this sense, Metformin (MET), an FDA-approved drug used type 2 diabetes, has shown anti-DENV effect in vitro by activating AMPK reducing HMGCR activity. study, MET was evaluated during vivo ZIKV infection compared to DENV infection. Our...
Flaviviruses, including Dengue (DENV), Zika (ZIKV), and Yellow Fever (YFV) viruses, represent a significant global health burden. The development of effective antiviral therapies against these viruses is crucial to mitigate their impact. This study investigated the potential cholesterol-lowering drugs atorvastatin ezetimibe in monotherapy combination DENV, ZIKV, YFV. In vitro results demonstrated dose-dependent reduction percentage infected cells for both drugs. showed synergistic effect...
Abstract High-density lipoprotein cholesterol (HDL-c) removes cholesterol, an essential component in lipid rafts, and this removal can regulate protein attachment to modulating their functionality the immune cell response. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection alter profile, there is little information on role of HDL-c other lipids prognostic disease 2019 (COVID-19) Mexican population. This study aims evaluate predictive value profile severity...
Metformin (MET) and atorvastatin (ATO) are promising treatments for COVID-19. This review explores the potential of MET ATO, commonly prescribed diabetes dyslipidemia, respectively, as versatile medicines against SARS-CoV-2. Due to their immunomodulatory antiviral capabilities, well cost-effectiveness ubiquitous availability, they highly suitable options treating virus. MET’s effect extends beyond managing blood sugar, impacting pathways that can potentially decrease severity fatality rates...
During flavivirus infection, some viral proteins move to the nucleus and cellular components are relocated from cytoplasm. Thus, integrity of main regulator nuclear-cytoplasmic transport, nuclear pore complex (NPC), was evaluated during infection with dengue virus (DENV) Zika (ZIKV). We found that while DENV distribution at least three nucleoporins (Nup), Nup153, Nup98, Nup62 were altered, ZIKV TPR, Nup98 modified. In this work, several lines evidence indicate serine protease NS2B3 is...
Dengue virus (DENV) uses cellular nuclear transport machinery to import some proteins into the nucleus. Recently, non-structural protein 3 (NS3) of DENV was localized in nucleus infected cells; however, its mechanism is still unknown. In this study, we demonstrate that Ivermectin (IVM) inhibits localization NS3 through inhibition Importin α/β1 pathway. We also report Atorvastatin (ATV) can modulate protease and NS5 polymerase DENV-2. On other hand, found IVM ATV treatments reduce alteration...
The risk of coronavirus disease 2019 (COVID-19) and dengue coinfection is increased in tropical countries; however, the extrapulmonary clinical manifestations have not been fully characterized. We report a 42-year-old woman whose began with fever, diarrhea, headache, chest pain, myalgia, odynophagia, arthralgia. Despite mild respiratory symptoms normal computed tomography scan results, she was diagnosed real-time reverse-transcription polymerase chain reaction (RT-PCR)-confirmed severe acute...
COVID-19 and dengue disease are challenging to tell apart because they have similarities in clinical laboratory features during the acute phase of infection, leading misdiagnosis delayed treatment. The present study evaluated peripheral blood cell count accuracy distinguish non-critical patients from non-severe cases between second eleventh day after symptom onset. A total 288 infected with SARS-CoV-2 (n = 105) or virus 183) were included this study. Neutrophil, platelet, lymphocyte counts...
Dengue, caused by the dengue virus (DENV), is a global health threat transmitted Aedes mosquitoes, resulting in 400 million cases annually. The disease ranges from mild to severe, with potential progression hemorrhagic dengue. Current research focused on natural antivirals due challenges vector control. This study evaluates antiviral of peptides derived microalgae Phaeodactylum tricornutum, known for its bioactive compounds. Microalgae were cultivated under controlled conditions, followed...
COVID-19 has a mortality rate exceeding 5.4 million worldwide. The early identification of patients at high risk is essential to save their lives. AST-to-lymphocyte ratio index (ALRI) novel biomarker survival in with hepatocellular carcinoma, an organ susceptible SARS-CoV-2 infection. For this study, the prognostic value ALRI as marker was evaluated. purpose, compared main biomarkers for (neutrophil-to-lymphocyte [NLR], systemic immune-inflammation [SII], platelet-to-lymphocyte [PLR],...
The severity of coronavirus disease 2019 (COVID-19) quickly progresses with unfavorable outcomes due to the host immune response and metabolism alteration. Hence, we hypothesized that leukocyte glucose index (LGI) is a biomarker for severe COVID-19. This study involved 109 patients usefulness LGI was evaluated compared other risk factors predict COVID 19 severity. identified as an independent factor (odds ratio [OR] = 1.727, 95% confidence interval [CI]: 1.026-3.048, P 0.041), area under...
Abstract Background COVID-19 has been recognized as an emerging and rapidly evolving health condition. For this reason, efforts to determine changes in laboratory parameters of patients biomarkers are urgent. Lipids essential components the human body, their modulation observed implicated some viral infections. Methods To evaluate clinical diagnosis utility lipid profile Mexican patients, one hundred two positive from three hospitals Culiacan, Sinaloa northwest Mexico, was analyzed. ROC...
Finding an effective therapy against diseases caused by flaviviruses remains a challenge. Here, we present protocol to test Food and Drug Administration-approved drugs that inhibit host nuclear protein import, promoting reduction of dengue infection. We describe steps for analyzing the drug effect on import inhibition cellular viral proteins confocal microscopy or western blotting. then procedures measuring antiviral effects virus-infected cells flow cytometry testing efficacy in...
During the COVID-19 pandemic, a considerable proportion of patients developed severe condition that included respiratory failure, shock, or multiple organ dysfunction. Acute Kidney Injury (AKI) has been recognized as possible cause development. Given this, this study investigates occurrence and consequences AKI in Mexican to contribute better knowledge management problem.
Background/Objectives: Coronavirus Disease 2019 (COVID-19) can cause liver injury and a deterioration of hepatic function. The Model for End-Stage Liver (MELD) score is good predictor poor prognosis hospitalized COVID-19 patients in the United States, Egypt Turkey. Nevertheless, best cut-off value MELD to predict mortality Mexican population has yet be established. Methods: A total 234 with were studied tertiary-level hospital. Patients stratified into survivors (n = 139) non-survivors 95)....