Biologically important and synthetically challenging spirocyclopentaneoxindoles with four contiguous stereocenters including one spiroquaternary stereocenter have been constructed in good yields (72–87%) excellent diastereoselectivity (16:1→30:1 dr) enantioselectivity (93→99% ee) by a combined Ru-catalyzed cross-metathesis/organocatalyzed asymmetric double-Michael addition sequence.

Abstract Background Cognitive dysfunction is the most common non-motor symptom in Parkinson’s disease (PD), and timely detection of a slight cognitive decline crucial for early treatment prevention dementia. This study aimed to build machine learning model based on intra- and/or intervoxel metrics extracted from diffusion tensor imaging (DTI) automatically classify PD patients without dementia into mild impairment (PD-MCI) normal cognition (PD-NC) groups. Methods We enrolled (52 PD-NC 68...

A highly diastereo- and enantioselective organocatalytic protocol for the synthesis of biologically important spirocyclopentaneoxindoles containing oxime functional group from easily accessible 3-allyl-substituted oxindoles nitroolefins has been developed by a one-pot Michael addition/ISOC/fragmentation sequence.

Abstract Emerging evidence has indicated that cognitive impairment is an underrecognized feature of multiple system atrophy (MSA). Mild (MCI) related to a high risk dementia. However, the mechanism underlying MCI in MSA remains controversial. In this study, we conducted amplitude low‐frequency fluctuation (ALFF) and seed‐based functional connectivity (FC) analyses detect characteristics local neural activity corresponding network alterations patients with (MSA‐MCI). We enrolled 80 probable...

Objective We wished to explore Parkinson's disease (PD) subtypes by clustering analysis based on the multimodal magnetic resonance imaging (MRI) indices amplitude of low-frequency fluctuation (ALFF) and gray matter volume (GMV). Then, we analyzed differences between PD subtypes. Methods Eighty-six patients 44 healthy controls (HCs) were recruited. extracted ALFF GMV according Anatomical Automatic Labeling (AAL) partition using Data Processing Analysis for Brain Imaging (DPABI) software. The...

Objective: Population-based cancer registration data in 2012 from all available registries Shandong province were collected by Center for Disease Control and Prevention (SDCDC).SDCDC estimated the numbers of new cases deaths with compiled incidence mortality rates.Methods: In 2015, there 21 submitted occurred 2012.All checked evaluated based on National Central Cancer Registry (NCCR) criteria quality.Qualified 15 used statistics analysis as provincial estimation.The pooled stratified area...

This study aimed to investigate the effects of different ferrule heights and crown-to-root ratios on fracture resistance endodontically-treated premolars restored with fiber post or cast metal system.Eighty extracted human mandibular first single root canal were treated endodontically cut from 2.0 mm above buccal cemento-enamel junction, create horizontal residual roots. The roots randomly divided into two groups. in group FP a post-and-core system, while MP system. Each was five subgroups...

To examine which anesthesia general or local is more effective for penetrating keratoplasty (PKP).Patients with indications PKP (n=141) were enrolled in a prospective study and randomly divided into group (group A, 70 eyes) B, 71 eyes). Patients received optical A1, 30 eyes; B1, therapeutic A2, 40 B2, 41 Measurement of anterior chamber treatment time (T) patients the ratio (R) area pupils to that recipient graft region. T R values, as well perioperative postoperative complications, compared...

The objective of this study was to evaluate the effect Er:YAG laser irrigation on push-out bond strength fiber posts root dentine. Sixty extracted human mandibular first premolars were collected and decoronated. residual roots received endodontic treatment. treated randomly divided into three groups according different protocols: group LAI (Er:YAG laser-activated irrigation), PUI (passive ultrasonic irrigation, positive control), CSI (conventional syringe negative control) (n = 20). Each two...

Purpose . To describe corneal endothelial characteristics, central thickness, and intraocular pressure in a population of Chinese age-related cataract patients to determine the effects age, gender, hypertension, body mass index (BMI). Methods 1551 eyes were examined preoperatively. The parameters measured cell density (CD), average area (CA), coefficient variation (CV), hexagonality (HEX), thickness (CCT), (IOP), axial length (AL). Results There significant differences CV BMI between...

// Zhentao Fu 1, * , Yingmei Li 2, Zilong Lu Jie Chu 1 Jiandong Sun 3 Jiyu Zhang Gaohui Fuzhong Xue 4 Xiaolei Guo ** and Aiqiang Xu Department for Chronic Non-Communicable Disease Control Prevention, Shandong Center Jinan, China 2 The Second People's Hospital of School Public Health Social Work, Queensland University Technology, Brisbane, Australia Health, University, first three authors contributed equally to this work last two Correspondence to: Guo, email: guoxiaolei@126.com Xu,...

Objective: To evaluate the characteristics, safety and effectiveness of a modified technique phacoemulsification in post-vitrectomy cataracts.Methods: This retrospective clinical trial comprised 31 patients (31 eyes) with cataract, who had undergone combined intraocular lens implantation. An alternative surgical known as anterior chamber was used for nucleus management those cases. The following parameters were evaluated: best corrected visual acuity (BCVA), ocular inflammation, pressure,...

Background In-stent restenosis (ISR) has become one of the most challenging problems in patients with coronary heart disease. At present, using non-invasive methods to assess ISR is a hot topic. In this investigation we attempted explore potential magnetocardiography (MCG) diagnosis in-stent restenosis. Methods MCG was analyzed 52 artery disease for three times: before stenting, month and 7 months after successful intracoronary stenting. Results The average classification total maps (ACTM)...

Abstract Objective To detect the spatial distribution and high‐risk clusters of lung cancer mortality for years 2011–2013 in Shandong Province, China. The urban–rural differences disease were also examined. Methods Lung data obtained from Death Registration System during 2011–2013, adjusted with underreporting rate. purely scan statistics method was carried out using a discrete Poisson model. Results Seven significant high detected Province at county level, mainly eastern, northern, central,...

Abstract Background To investigate the effects of different ferrule heights and crown-to-root ratios on fracture resistance endodontically-treated premolars restored with two post-and-core systems. Methods Eighty extracted human mandibular first single root canal were treated endodontically cut from 2.0 mm above buccal cemento-enamel junction, to create horizontal residual roots. The roots randomly divided into groups. in group FP a fiber system, while MP cast metal system. Each was five...

Aplastic anemia (AA) is a heterogeneous group of hematopoietic failure diseases, characterized mainly by immune hyperfunction, impaired tolerance, the microenvironment, and stem or progenitor cell deficiency. Oligoclonal hematopoiesis clonal evolution make disease more complicated, extremely challenging to diagnose. After immunosuppressive therapy (IST) granulocyte colony-stimulating factor (G-CSF) treatment, AA patients have risk developing acute leukemia.Here we report patient with...

Abstract Background Elder population is considered as a vulnerable group with high risk of dental caries. The older adults living in rural areas Yunnan province account for approximately half the province’s total population. However, few studies have addressed their caries status. purpose present study was to investigate status and its associated factors among 65-74 years old people province, China. Methods This cross-sectional recruited participants through multistage stratified strategy,...

Abstract Background: Elder population is considered as a vulnerable group with high risk of dental caries. The older adults living in rural areas Yunnan province account for approximately half the province’s total population. However, few studies have addressed their caries status. purpose present study was to investigate status and associated factors among 65-74 years old people province, China. Methods: This cross-sectional recruited participants through multistage stratified strategy,...