A5060240723- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Epigenetics and DNA Methylation
- Photodynamic Therapy Research Studies
- Bioactive Compounds and Antitumor Agents
- Immune cells in cancer
- Insect Pest Control Strategies
- Essential Oils and Antimicrobial Activity
- Single-cell and spatial transcriptomics
- Ethnobotanical and Medicinal Plants Studies
- Natural Antidiabetic Agents Studies
- Plant Parasitism and Resistance
- African Botany and Ecology Studies
- Phytochemistry and Bioactivity Studies
- Bacillus and Francisella bacterial research
- Moringa oleifera research and applications
- Biological Activity of Diterpenoids and Biflavonoids
- Plant Diversity and Evolution
- Phytochemicals and Antioxidant Activities
- bioluminescence and chemiluminescence research
- Cell Image Analysis Techniques
Universidade Federal de São Carlos
2025
Instituto Nacional do Câncer
2023-2024
Universidade Estadual de Campinas (UNICAMP)
2015-2023
Abstract Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment responses due to their remarkable plasticity tumorigenic behaviors. Here, we integrate single-cell RNA-sequencing data from different types, identifying 29 MDC subpopulations within the tumor microenvironment. Our analysis reveals abnormally expanded across various tumors distinguishes cell states that have often been grouped together, such as TREM2+ FOLR2+ subpopulations. Using...
New faster and more sensitive detection methods are required for food microbiological contamination quality control throughout the entire handling process. The adenosine triphosphate (ATP) bioluminescence method based on firefly luciferin–luciferase system has been a widely used approach decades due to its practicality, efficiency, rapidity. luciferase of Amydetes vivianii firefly, cloned produced in our laboratory, displays high stability, showing desirable properties ATP assays. Using this...
Essential oil from the leaves of Guatteria australis was obtained by hydrodistillation, analyzed Gas Chromatography coupled to Mass Spectromery (GC–MS) and their antiproliferative, antileishmanial, antibacterial, antifungal antioxidant activities were also evaluated. Twenty-three compounds identified among which germacrene B (50.66%), D (22.22%) (E)-caryophyllene (8.99%) main compounds. The highest antiproliferative activity observed against NCI-ADR/RES (TGI = 31.08 μg/ml) HT-29 32.81 cell...
Brazilian ginseng, including Pfaffia townsendii, is used in popular medicine as a natural anti-inflammatory, tonic, analgesic, and antidiabetic agent. In this study, we investigated the chemical composition evaluated antioxidant anti-inflammatory activities of P. townsendii ethanolic extract well major isolated glycoside flavonoids tiliroside patuletin 3-O-β-D-glucopyranoside. Chromatographic techniques spectroscopic analysis were for isolation identification compounds. The potential was...
The essential oil obtained by hydrodistillation from leaves of Anaxagorea brevipes was analysed gas chromatography fitted with a flame ionisation detector (GC-FID) and coupled to mass spectrometry (GC-MS). Thirty one components were identified, representing around 75.7% total oil. major β-eudesmol (13.16%), α-eudesmol (13.05%), γ-eudesmol (7.54%), guaiol (5.12%), caryophyllene oxide (4.18%) β-bisabolene (4.10%). showed antimicrobial activity against Gram-positive bacteria yeast the MIC...
Phytochemical study of aerial parts from Sinningia mauroana Chautems (Gesneriaceae) yielded 17 known compounds: sitosterol, stigmasterol, betulinic acid, oleanolic hederagenin, maslinic ursolic pomolic soranjidiol, methyl 4-hydroxyphenylacetate, 6-hydroxy-7-methoxy-a-dunnione, 7-hydroxy-6-methoxy-a-dunnione, jacaranone, calceolarioside A, conandroside, luteolin, and luteolin-7-O-glucoside.Complete NMR data 6-hydroxy-7-methoxy-a-dunnione 7-hydroxy-6-methoxy-a-dunnione were obtained in two...
A new naphthoquinone, 6-hydroxy-7-methoxy-2- O-methylduniol (1), was isolated from the tubers of Sinningia hatschbachii Chautems (Gesneriaceae), together with 10 known compounds: 7-hydroxy-α-dunnione, 7-hydroxy-6-methoxy-α-dunnione, 2,4,4’,6-tetramethoxydihydrochalcone, 4’-hydroxy-2,4,6-trimethoxydihydrochalcone, 4’,2-dihydroxy-4,6-dimethoxydihydrochalcone, methyl 1-hydroxy-4-methoxy-2-naphthoate, 1,4-dimethoxy-2-naphthoate, 4-hydroxybenzoate, calceolarioside B, and conandroside. All...
Abstract Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment response due to their remarkable plasticity tumorigenic behaviors. We integrated single-cell RNA-Sequencing datasets from seven different cancers, resulting in a comprehensive collection of 29 MDC subpopulations the tumor microenvironment (TME). Distinguishing resident-tissue monocyte-derived macrophages, we discovered resident-tissue-like subpopulation within macrophages. Additionally,...
Abstract Photodynamic therapy (PDT) has been used for various purposes, including as an antitumor resource in a noninvasive with minimal side effects. Sinningia magnifica (Otto & A. Dietr.) Wiehler is rupicolous plant found rock crevices Brazilian tropical forests. Initial studies indicate the presence of phenolic glycosides and anthraquinones species genus (Generiaceae family). It known that are natural photosensitizers potential PDT applications. This led us to investigate compounds S....