A5101919325- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Analytical Chemistry and Sensors
- Neurobiology and Insect Physiology Research
- Neuropeptides and Animal Physiology
- Neuroscience of respiration and sleep
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Polymer Nanocomposite Synthesis and Irradiation
- Lysosomal Storage Disorders Research
- Ferroptosis and cancer prognosis
- Pharmacological Effects and Assays
- Genetics and Neurodevelopmental Disorders
- Immunotherapy and Immune Responses
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Nicotinic Acetylcholine Receptors Study
- Xenotransplantation and immune response
- CAR-T cell therapy research
- Tissue Engineering and Regenerative Medicine
- Nuclear Receptors and Signaling
- Cellular transport and secretion
- EEG and Brain-Computer Interfaces
- Anesthesia and Neurotoxicity Research
- Polymer crystallization and properties
Zhejiang University
2000-2025
Women's Hospital, School of Medicine, Zhejiang University
2025
Hangzhou Medical College
2023
Zhejiang Provincial People's Hospital
2023
Jinhua Central Hospital
2023
Shanghai Jiao Tong University
2023
Sir Run Run Shaw Hospital
2017
Guangzhou University of Chinese Medicine
2016
McMaster University
2012-2015
Howard University
1990-1993
The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for autophagosome-lysosome in mammals, yet reconstituting the mammalian HOPS remains a challenge. Here we propose "hook-up" model assembly, which requires two sub-complexes docking on membranes via membrane-associated Rabs. We identify Rab39A as key small GTPase that recruits onto autophagic vesicles. Proper pairing with Rab2 enables assembly between proteoliposomes its tethering...
Abstract Type 1 conventional dendritic cells (cDC1s) are key antigen‐presenting that efficiently activate CD8 + T cells, driving strong anti‐tumor immunity. cDC1s migration to the lymph node is a pivotal component. Previous studies often focused on enhancing (DCs) via CC chemokine receptor (CCR) 7 – ligand (CCL) 19/21 pathway, while simultaneously increasing tumor cell metastasis. In this study, new strategy provided accelerate DCs’ movement out of by reprograming their glutamine metabolism...
To elucidate whether the endometriotic cells of endometriomas synthesize transforming growth factor beta1 (TGF-beta1) and understand how it affects surrounding ovarian tissue. We collected biopsies cystic walls from 42 29 mature teratomas compared mRNA protein expression fibrosis-related factors between walls. Then we detected TGFB1 synthesis in endometriomas, tested TGF-beta1 fibrotic effect vitro. Moreover, verified Smad2/3 signaling components wall order to TGF-beta1/Smad is involved...
We have reported that clinically relevant concentrations of valproic acid (VPA) up-regulate the G-protein-coupled melatonin MT1 receptor in rat C6 glioma cells. To determine whether this effect occurs vivo, effects chronic VPA treatment on expression both subtypes, and MT2, were examined brain. Reverse transcription–polymerase chain reaction (RT–PCR) real-time PCR analyses revealed significant increases MT2 mRNA hippocampus, following (4 mg/ml drinking water) for 17 d. Increases protein...
The aim of the present study was to investigate antidepressant-like effects two fractions, including petroleum ether soluble fraction (Fraction A, FA) and water-EtOH B, FB) prepared from Danzhi-xiaoyao-san (DZXYS) by using chronic unpredictable mild stress-induced depressive rat model. results indicated that DZXYS could ameliorate depression-like behavior in stress model rats. inhibition hyperactivity HPA axis modulation monoamine amino acid neurotransmitters hippocampus may be important...
Valproic acid (VPA), a short-chain fatty acid, is used clinically as an anticonvulsant and mood stabilizer. also inhibits histone deacetylase activity, which associated with hyperacetylation changes in gene expression. In this study, we examined the effects of VPA on expression selected neurotrophic differentiation factors C17.2 neural stem cells. Reverse transcription-polymerase chain reaction analysis revealed significant increase conserved dopamine factor (CDNF) glial cell line-derived...
PLU1 is upregulated in many cancers, including breast, mammary, colorectal, and hepatocellular carcinoma. However, little known about the potential metabolic mechanisms of glioma progression. Therefore, we investigated relationship between development.We analyzed expression World Health Organization (WHO) grade using clinical databases verified role development transcriptome sequencing, Western blotting, Cell Counting Kit 8, colony formation, wound healing assays. The glucose metabolism was...
Using the difference-in-differences (DID) model and taking sample of companies listed from 2009 to 2014 on Growth Enterprises Market (GEM) Shenzhen Stock Exchange in China, this paper studies impact Venture Capital (VC) participation board characteristics, which is measured by chief executive officer (CEO) duality, scale directors proportion independent directors, it also how characteristics influence company performance. The findings are as follows: VC-backed GEM more inclined choose mode...
An advanced control system used in assisted circulation apparatus of artificial liver support was developed based on embedded platform and field bus. This consisted a cardiopulmonary bypass-controlling system, blood reactors status-monitoring human-machine interface communication system. Multiple functions are implemented such as on-line monitoring, controlling driving the apparatus, real-time supervising regulating physiological environments reactors, convenient, rapid operation mode, with...
The temperature-dependent resistivity behavior of carbon black–loaded polyethylene (PE) composites irradiated both at room temperature and 170°C above the PE melting point was studied. irradiation doses were varied. At a given loading level, corresponded to an energy treatment on low-resistive, solid, three-phase composite system, while high it high-resistive, viscous, two-phase system. condition had complicated influence electrical response temperature. resulting structure analyzed by using...
In this work we present a new approach of dot map to analyze heart rate variability (HRV), using the sequence RR intervals by first order difference, which is based on mapping Poincare plots. We characteristic plot obtain its indexes express HRV, and detect kinds premature beats from ectopic plots area. As natural interval vary slowly there complete compensation after beat, had especial also some peculiar isolated areas academic logic. This was proved be correct test MIT-BIH arrhythmia...
New target controlled infusion (TCI) for propofol using a hybrid physiologically based pharmacokinetic (PBPK) model was proposed in this paper. The composed of three-compartment mamillary systemic and two-compartment brain model. A closed-loop control algorithm with concentration as the variable used to calculate infusion. Finally, dose regimen applied clinical practice recorded auditory evoked potentials showed good depth anaesthesia. TCI feasible had potential applications.
Research of the marine meiobenthos is great value in ecology and mineralogy. At present, picking up from sedments manually under microscope still prvalent spite large consumption human power time. So that this paper, an automatic separation system was established. The excellent performance separating demonstrated by precision above 95%.
Sn–Pb alloy-loaded polystyrene (PS) composites were processed by powder mixing and hot pressing. For the hot-pressed at temperatures below melting point of alloy, resistivity dropped sharply if alloy volume fraction reached 20 vol %. When above point, such phenomenon disappeared. According to SEM energy dispersive analysis X-ray (EDAX) analyses, size dispersion particles in changed when hot-pressing temperature which resulted different forms resistivity–filler curves. © 2000 John Wiley &...