A5014314248- Synthesis and biological activity
- Computational Drug Discovery Methods
- Bioactive Compounds and Antitumor Agents
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Receptor Mechanisms and Effects
- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Synthesis and Biological Evaluation
- Natural Antidiabetic Agents Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Phytochemistry and Biological Activities
- Plant-based Medicinal Research
- Synthesis and Reactivity of Heterocycles
- Fatty Acid Research and Health
- Analytical Methods in Pharmaceuticals
- Synthesis and Reactions of Organic Compounds
- Neuroscience and Neuropharmacology Research
- Cancer therapeutics and mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Malaria Research and Control
- Synthesis and bioactivity of alkaloids
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Multicomponent Synthesis of Heterocycles
- Botanical Research and Chemistry
University of Karachi
2013-2024
University of Gujrat
2024
International Center for Chemical and Biological Sciences
2012-2022
University of Tübingen
2001-2002
The synthesis and selective biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) some their derivatives were carried out. Compound 13 was found to be most potent cytotoxic agent with LD50 = 126.69 μg/ml. In antibacterial assay the compounds showed a broad spectrum activities. 11 exhibited very high degree plant growth inhibition at three levels concentration. 4 promising antifungal activity against Candida albicans. Compounds 12...
Abstract Objective: After the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a pandemic, intense efforts to combat novel were undertaken, with many fatalities in most regions of world. The high fatality rate and socioeconomic collapse affected health uninfected individuals because healthcare measures scheduled clinical hospital visits avoided by people an attempt reduce their exposure contagion. general population began self-medication practices as means...
Zanthoxylum alatum Roxb., is a medicinal plant which abundantly grows in the hilly areas of Pakistan. The dried fruit used as condiment and has excellent spice value. In present study, antioxidant activity Z. whole was evaluated by several vitro systems e.g., lipid peroxidation, 2,2-diphenlyl-1-picrylhydrazyl (DPPH), hydroxyl radicals scavenging activities, phosphomolybdenum assay metal chelation activity. ethanolic extracts showed inhibition against Thiobarbituric acid reactive substances...
A series of N-substituted morpholines 2-20 was synthesised by reacting various acid chlorides and alkyl halides with morpholine (1). All the compounds were screened for their leishmanicidal effects using amphotericin B (IC(50) = 0.24 microg L(-1)) pentamidine 2.56 mL(-1)) as standards a structure-activity relationship (SAR) study established. The 2 48 mL(-1)), 3 30.0 10 41.0 15 33.0 16 35.0 20 47.0 showed weak activities.
New derivatives of quinoline (CAS 91-22-5, Z-1) were synthesized and their potential therapeutical significance structure-activity relationship tested. The brine shrimp bioassay was carried out to study in vitro cytotoxicity, besides, also antimicrobial, antifungal cardiovascular activities investigated. Some structures showed a high degree activity on the isolated rabbit jejunum. Extensive spectroscopic techniques such as EIMS, FABMS, peak matching MS, UV, IR <sup>1</sup>Η NMR employed...
Abstract 7-Hydroxy-4-methyl-2 H -chromen-2-one (2) , 7-hydroxy-4,5-dimethyl-2 (15) and their some derivatives were synthesized for exploring selected biological screening. The compounds 9 13 had shown high degree of cytotoxic activity. Three compound 10 showed bactericidal activity amongst the present series. Keywords: -chromen-2-one7-Hydroxy-4,5-dimethyl-2 DerivativesCytotoxicityBactericidal Activity
In the present study, some 9-aminoacridine derivatives have been synthesized by condensation of with substituted phenacyl, benzoyl, and benzyl halides (RM1-RM6). Compounds were investigated for acetylcholinesterase butyrylcholinesterase inhibition potential, considering these enzymes playing a key role in Alzheimer’s disease. All showed better than standard galantamine, whereas except RM4, all exhibit results tacrine, well-known acridine derivative used treatment
A variety of piperidines (2-12, 14-26) with variable substituents at N-atoms have been synthesized and evaluated as urease inhibitors. The compounds showed varying degree inhibitory activity ranging from 31.97 to 254 microM. size electron-donating or -withdrawing effects influence the activity, which lead formation
In the context of our previous communication on phytochemical studies ethanolic extract flowers Alstonia scholaris Pakistan origin, these have resulted in isolation two new triterpenoids. One is oleanane type, alstoprenyol, 3-β-hydroxy-28-β-acetoxy-5-olea triterpene (1), other ursane alstoprenylene 3β-acetate-24-nor-urs-4,12,2′-triene ester (2) and together with four known triterpenes, α-amyrin acetate (3), (4), lupeol (5) 3β-hydroxy-24-nor-urs-4,12,28-triene (6) were isolated. The...
Cobalamins are the largest and structurally complex cofactors found in biological systems have attracted considerable attention due to their participation metabolic reactions taking place humans, animals, microorganisms. Riboflavin (vitamin B 2 ) is a micronutrient precursor of coenzymes, FMN FAD, required for wide variety cellular processes with key role energy-based reactions. As coenzymes both vitamins part enzyme systems, possibility mutual interaction body cannot be overruled. A...
Synthesis and analgesic activity of 4-phenylpiperidine derivatives is a topic high actuality. A s part programme towards obtaining new potential analgesics, ten 4- acetyl-4-phenylpiperidine 4-hydroxy-4-phenylpiperidine were synthesised characterized through spectroscopic techniques. All along with the parent compounds evaluated for in acetic acid-induced writhing assay tail-flick test mice. 4-acetyl-4-phenylpiperidine except one com pound exhibited more or less protection against mice...