A5009048221- Nanoparticles: synthesis and applications
- Atherosclerosis and Cardiovascular Diseases
- Microbial Fuel Cells and Bioremediation
- Angiogenesis and VEGF in Cancer
- Laser-Ablation Synthesis of Nanoparticles
- Advanced Nanomaterials in Catalysis
- Trace Elements in Health
- Hydrogen embrittlement and corrosion behaviors in metals
- Peptidase Inhibition and Analysis
- Cerebrovascular and Carotid Artery Diseases
- Animal Genetics and Reproduction
- Biochemical and Structural Characterization
- Infective Endocarditis Diagnosis and Management
- Calpain Protease Function and Regulation
- Adipose Tissue and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Algal biology and biofuel production
- CO2 Reduction Techniques and Catalysts
- Milk Quality and Mastitis in Dairy Cows
- Inflammatory Biomarkers in Disease Prognosis
- Probiotics and Fermented Foods
- Electrocatalysts for Energy Conversion
- Corrosion Behavior and Inhibition
- Prostate Cancer Treatment and Research
- Single-cell and spatial transcriptomics
University of Louisville
2022-2023
Dublin City University
2014-2022
APC Microbiome Institute
2019
University College Cork
2019
Teagasc - The Irish Agriculture and Food Development Authority
2019
Bovine mastitis is an ongoing significant concern in the dairy and agricultural industry resulting substantial losses milk production revenue. Among predominant etiological agents of bovine are Staphylococcus aureus, Streptococcus uberis, dysgalactiae, Escherichia coli. Currently, treatment choice for involves use commercial therapeutic antibiotic formulations such as TerrexineTM, containing both kanamycin cephalexin. Such antibiotics regularly administered more than one dose withholding...
Improved prostate cancer detection methods would avoid over-diagnosis of clinically indolent disease informing appropriate treatment decisions. The aims this study were to investigate the role a panel Inflammation biomarkers inform need for biopsy diagnose cancer. Peripheral blood serum obtained from 436 men undergoing transrectal ultrasound guided assessed 18 inflammatory in addition Total and Free Prostate Specific Antigen (PSA). This was integrated into previously developed Irish clinical...
Biosynthesis of gold nanoparticles (AuNPs) for antimicrobial and chemotherapeutic applications is a well-established process in microbial hosts such as bacterial, fungi, plants. However, reports on AuNPs biosynthesis mammalian cells are scarce. In this study, bovine aortic endothelial (BAECs) smooth muscle (BASMCs) were examined their ability to synthesize vitro. Cell culture conditions buffer selection, serum concentration, HAuCl4 concentration optimized before the biosynthesized...
Drug-eluting stents (DES) are mostly used in percutaneous coronary intervention, which is the main treatment for artery occlusion. This procedure aims to restore natural lumen, while minimizing risk of restenosis. However, stent insertion increases infections, due contamination device or hub with normal skin flora. While infection a rare complication, it can be fatal. Currently, there little information on biofilm formation everolimus-eluting stents. Although everolimus not designed as an...
Abstract A hallmark of subclinical atherosclerosis is the accumulation vascular smooth muscle cell (SMC)-like cells leading to intimal thickening and lesion formation. While medial SMCs contribute lesions, involvement resident stem (vSCs) remains unclear. We evaluated single photonics as a discriminator phenotype in vitro before presence vSC within lesions was assessed ex vivo using supervised machine learning further validated lineage tracing analysis . Using novel lab-on-a-Disk(Load)...
Calcium-dependent peptidases of the calpain family are widespread in eukaryotes but uncommon prokaryotes. A few bacterial homologs have been discovered none them characterized detail. Here we present an in-depth substrate specificity analysis calpain-like peptidase Tpr from Porphyromonas gingivalis. Using positional scanning hybrid combinatorial library method, found that differs substantially papain cysteine proteases, showing a strong preference for proline residues at positions P2 and P3....
Abstract A hallmark of subclinical atherosclerosis is the accumulation vascular smooth muscle cell (SMC)-like cells leading to intimal thickening and lesion formation. While medial SMCs contribute lesions, involvement resident stem (vSCs) remains unclear. We evaluated single photonics as a discriminator phenotype in vitro before presence vSC within lesions was assessed ex vivo using supervised machine learning further validated lineage tracing analysis. Using novel lab-on-a-Disk (Load)...