A5005415926- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- vaccines and immunoinformatics approaches
- Adipose Tissue and Metabolism
- Assistive Technology in Communication and Mobility
- CAR-T cell therapy research
- Chromosomal and Genetic Variations
- Neurobiology and Insect Physiology Research
- E-Learning and Knowledge Management
- Sirtuins and Resveratrol in Medicine
- Circadian rhythm and melatonin
- Cervical Cancer and HPV Research
- interferon and immune responses
- Mitochondrial Function and Pathology
- Autism Spectrum Disorder Research
- Innovative Approaches in Technology and Social Development
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- Innovative Teaching and Learning Methods
- Hepatitis B Virus Studies
- Genomics and Phylogenetic Studies
University of Copenhagen
2014-2023
BioInnovation Institute
2021-2023
Novo Nordisk Foundation
2018-2023
Inprother (Denmark)
2021-2022
Aalborg University
2017
Novo Nordisk (Denmark)
2014
The ability of adipose tissue to expand and contract in response fluctuations nutrient availability is essential for the maintenance whole-body metabolic homeostasis. Given scarcity that mammals faced millions years, programs involved this plasticity were likely evolved be highly efficient promoting lipid storage. Ironically, previously advantageous feature may now represent a liability given caloric excess modern society. We speculate nicotinamide adenine dinucleotide (NAD+) biosynthesis...
Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating input from hypothalamic master clock and intracellular metabolic signals. One such key signal is cellular concentration of NAD + , which oscillates along with its biosynthetic enzyme, nicotinamide phosphoribosyltransferase (NAMPT). levels feed back into to influence rhythmicity biological functions, yet whether this fine-tuning occurs ubiquitously across cell types a core feature unknown. Here, we...
Endogenous retroviruses (ERVs) account for 8% of our genome, and, although they are usually silent in healthy tissues, become reactivated and expressed pathological conditions such as cancer. Several studies support a functional role ERVs tumour development progression, specifically through their envelope (Env) protein, which contains region described an immunosuppressive domain (ISD). We have previously shown that targeting the murine ERV (MelARV) Env using virus-like vaccine (VLV)...
Abstract Adenoviral vectors have long been forerunners in the development of effective CD8 T cell–based vaccines; therefore, it is imperative that we understand factors controlling induction robust and long-lasting transgene-specific immune responses by these vectors. In this study, investigated organ sites, molecules, cell subsets play a critical role priming cells after vaccination with replication-deficient adenoviral vector. Using human adenovirus serotype 5 (Ad5) vector genetically...
We have previously shown that for the majority of antigens, adenoviral vaccines expressing target antigen fused to MHC associated invariant chain (Ii) induce an accelerated, augmented, and prolonged transgene-specific CD8(+) T-cell response. Here we describe a new vaccine vector approach where Ii is expressed from E1 region IL-2 E3 region. Immunization mice with this construct resulted in augmented primary effector Furthermore, melanoma model observed significantly tumor control vaccinated...
Abstract As a result of the difficulties in making efficient vaccines against genetically unstable viruses such as HIV, it has been suggested that future should preferentially target subdominant epitopes, idea being this allow greater breadth induced T cell response and, hence, efficiency controlling escape variants. However, to our knowledge evidence supporting concept is limited at best. To improve upon this, we used murine lymphocytic choriomeningitis virus model and adenoviral vectors...
The paper raised the question of how residents a rehabilitation and education center in Denmark use center's main corridor to seek for or engage social focused activities. With this, we aim inform design Smart Learning Ecosystem support adolescents with brain injury informal learning. We argue that research on smart learning environments has as too strong focus classroom interaction often neglects socially situated interactional side Instead, investigate (1) can be understood place learning;...
<h3>Background</h3> Human endogenous retroviruses and, in particular the betaretrovirus HERV-K, are upregulated at protein level a wide range of cancers. Spontaneous immunity to HERV-K has been observed autoimmune diseases and Recently, Ng et al., studying non-small-cell lung cancer (NSCLC) linked presence transcripts formation tertiary lymphoid structures, antibody-dependent cellular cytotoxicity clinical responses checkpoint inhibitor therapy. Other NSCLC expressed gamma-retroviral HERVs...