A5101431131- DNA Repair Mechanisms
- Autophagy in Disease and Therapy
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Natural product bioactivities and synthesis
- RNA regulation and disease
- Alzheimer's disease research and treatments
- Animal Genetics and Reproduction
- Toxin Mechanisms and Immunotoxins
- Phytochemical Studies and Bioactivities
- Carcinogens and Genotoxicity Assessment
- Tryptophan and brain disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Microbial Community Ecology and Physiology
- Phytochemistry and Biological Activities
- Kruppel-like factors research
- Vibrio bacteria research studies
- Microbial Natural Products and Biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Reproductive Biology and Fertility
- Effects of Radiation Exposure
- Molecular Biology Techniques and Applications
- PARP inhibition in cancer therapy
- RNA Research and Splicing
- Heavy metals in environment
Shenyang Pharmaceutical University
2007-2024
Sichuan University
2021
West China Hospital of Sichuan University
2021
West China Medical Center of Sichuan University
2021
First Hospital of Jilin University
2020
Jilin University
2020
Chongqing Medical University
2020
Northeastern University
2017
Bethune International Peace Hospital
2015-2016
University Town of Shenzhen
2007
Abstract A new surfactin isomer (1) was isolated from a mangrove bacteria strain ‘ Bacillus sp’. Its structure identified, and full assignments of 1 H 13 C NMR spectral data were achieved for the first time by combination mass spectrometry 1D 2D experiments including DEPT, H COSY, HSQC, HMBC, TOCSY, ROESY, HSQC‐TOCSY. The eight known analogs (2–9) are also reported. Copyright © 2007 John Wiley & Sons, Ltd.
Silibinin is an active constituent extracted from blessed milk thistle (Silybum marianum). Our previous study demonstrated that silibinin induced autophagy and apoptosis via reactive oxygen species (ROS) generation in HeLa cells. In this study, we investigated whether the autophagy- apoptosis-associated molecules also involved ROS generation. promoted expression phosphorylated-p53 (p-p53) a dose-dependent manner. Pifithrin-α (PFT-α), specific inhibitor of p53, reduced production reversed...
Abstract Two new oxidized sterols 1 and 2 were obtained from the active fraction of a mangrove fungus Aspergillus awamori isolated soils around plant Acrostichum speciosum . Their structures elucidated using spectroscopic methods as 22 E ‐7α‐methoxy‐5α,6α‐epoxyergosta‐8(14),22‐dien‐3β‐ol (1) ‐3β‐hydroxy‐5α,6α,8α,14α‐diepoxyergosta‐22‐en‐7‐one (2). The NMR data complete assignments for both DMSO‐ d 6 CDCl 3 given. cytotoxic activity against A549 cell line was evaluated. Furthermore, detailed...
Abstract The functional alterations of proteins and nucleic acids mainly rely on their modifications. ADP-ribosylation is a NAD + -dependent modification and, in some cases, acids. This broadly categorized as Mono(ADP-ribosyl)ation (MARylation) or poly(ADP-ribosyl)ation (PARylation). MARylation catalyzed by mono(ADP-ribosyl) transferases (MARTs) more common cells the number MARTs much larger than poly(ADP-ribosyl) transferases. Unlike PARylation well-characterized, research at starting...
A new triterpenoid saponin, named stauntoside (1) along with four known saponins (2,3,4,5) was isolated from Stauntonia chinensis DC., (Lardizabalaceae). Their structures were elucidated by spectroscopic analysis and chemical methods as 3-O-alpha-L-arabinopyranosyl-30-norhederagenin -28-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (1), 3-O-alpha-L-arabinopyranosyl-30- norhederagenin-28-O-alpha-L-rhamnopyranosyl-(1 4)-beta-D-glucopyranosyl-(1 (2),...
Wnt signaling is critical in embryonic development and post-embryonic tissue homeostasis. The aim of the present study was to evaluate expression levels canonical genes porcine somatic cell nuclear transfer (SCNT) embryos. Quantitative polymerase chain reaction analysis performed SCNT embryos, results indicated that temporal patterns were similar between vivo embryos from 2-cell blastocyst stage. In addition, aberrant a small number identified. IWP2, an inhibitor processing, applied culture...
Cadmium (Cd) is an industrial and environmental pollutant that targets the vascular endothelium. The system critically affected by Cd toxicity. Recent studies have indicated association between diseases, although mechanisms of implications in diseases are not clear. purpose present study was to determine whether epalrestat (EPS), which used for treatment diabetic neuropathy, protects against Cd-induced cytotoxicity bovine aortic endothelial cells (BAECs). In study, effects EPS at near-plasma...
Numerous studies have suggested that ketamine administration can induce neuroapoptosis in primary cultured cortical neurons. Neurosteroids modulate neuronal function and serve important roles the central nervous system, however role of neurosteroids induced by remains to be elucidated. The present study aimed explore whether neurosteroidogenesis was a pivotal mechanism for neuroprotection against ketamine-induced neuroapoptosis, it may selectively regulated under conditions To this...
Mammalian cells in culture have been used to study the genetic effects of physical and chemical agents. We Chinese hamster ovary (CHO) cells, clone K1-BH4, quantify mutations at X-linked, large (35 kb) hypoxanthine-guanine phosphoribosyltransferase (hprt) locus (the CHO/HPRT assay) induced by environmental By transfecting an hprt-deletion mutant CHO cell line with plasmid vector pSV2gpt, we isolated a transformant, AS52. AS52 carry single functional copy autosomal, small (456 bp)...
We have isolated independent Chinese hamster ovary (CHO) cell mutants at the hypoxanthine guanine phosphoribosyltransferase (hprt) locus from untreated, 60Co gamma-ray-exposed, and 212Bi alpha-exposed cells identified molecular changes underlying mutation determined by multiplex polymerase chain reaction (PCR)-based exon deletion analysis. Both parental CHO-K1 X-ray-sensitive mutant xrs-5 were studied. The radiosensitive are defective in DNA double-strand break rejoining ability V(D)J...