A5103155928- PARP inhibition in cancer therapy
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Stress Responses and Cortisol
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Alzheimer's disease research and treatments
- Cardiac Ischemia and Reperfusion
- Cholinesterase and Neurodegenerative Diseases
- interferon and immune responses
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutropenia and Cancer Infections
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- Mesenchymal stem cell research
- Cardiovascular Effects of Exercise
- Metabolism, Diabetes, and Cancer
- Liver physiology and pathology
- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
Zhejiang University
2014-2025
Henan University of Science and Technology
2022-2023
Bethune International Peace Hospital
2005-2023
Institute of Pharmacology
2017-2023
Yangzhou University
2004-2017
Hangzhou Academy of Agricultural Sciences
2017
ZheJiang Institute For Food and Drug Control
2012
Inner Mongolia Electric Power (China)
2010
// Ling Ding 1 , Guikai Liang Zhangting Yao Jieqiong Zhang Ruiyang Liu Huihui Chen Yulu Zhou Honghai Wu Bo Yang Qiaojun He Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute Pharmacology and Toxicology, College Pharmaceutical Sciences, University, Hangzhou 310058, China Correspondence to: He, e-mail: qiaojunhe@zju.edu.cn Keywords: metformin, macrophage polarization, cancer metastasis, AMPKα1 Received: July 05, 2015 Accepted: October...
Abstract Studies have pointed to a role of PARP1 in regulating gene expression through poly(ADP-ribosyl)ating, sequence-specific, DNA-binding transcription factors. However, few examples exist that link this the immunogenicity cancer cells. Here, we report poly(ADP-ribosyl)ates STAT3 and subsequently promotes dephosphorylation, resulting reduced transcriptional activity PD-L1. In study, showed silencing or pharmacologic inhibition enhanced PD-L1 cells, which was accompanied by upregulation...
Although M2-like tumor-associated macrophages (TAMs) have been considered as a vital therapeutic target in cancer therapy due to their role promoting tumor progression and metastasis, very few compounds identified inhibit polarization of TAMs. Here, we showed that Imatinib significantly prevented macrophage induced by IL-13 or IL-4 vitro, illustrated reduced expression cell surface marker CD206 genes, including Arg1, Mgl2, Mrc1, CDH1, CCL2. Further, the migration lung cells promoted...
Understanding the regulatory mechanisms of PD-L1 expression in tumors provides key clues for improving immune checkpoint blockade efficacy or developing novel oncoimmunotherapy. Here, we showed that FDA-approved sodium-glucose cotransporter-2 (SGLT2) inhibitor canagliflozin dramatically suppressed and enhanced T cell-mediated cytotoxicity. Mechanistic study revealed SGLT2 colocalized with at plasma membrane recycling endosomes thereby prevented from proteasome-mediated degradation....
Tumor-associated macrophages (TAMs) has been regarded as the most prominent component in tumor microenvironment. The correlation between TAM density and poor prognosis Hepatocellular carcinoma (HCC) patients suggests a supportive role for TAMs progression. Here we employed co-culture system to interrogate molecular link Yes-Associated Protein (YAP) chemotaxis HCC cells. We found that YAP activation was critical recruitment of towards Furthermore, cytokine array quantitative RT-PCR analyses...
In recent years, a large amount of clinical and experimental data has shown that M2-like polarized tumor-associated macrophages (TAMs) play an important role in cancer metastasis. Therefore, TAMs, especially TAMs is promising target for anti-tumor metastasis therapy. Here, we found celastrol dose-dependently suppressed IL-13 induced CD206 expression both RAW264.7 primary macrophages. Consistently, also inhibited the specific genes, including MRC1, Arg1, Fizz1, Mgl2 CD11c. Further, by...
Abstract The intracellular distribution and transportation process are essential for maintaining PD‐L1 (programmed death‐ligand 1) expression, intervening in this cellular may provide promising therapeutic strategies. Here, through a cell‐based high content screening, it is found that the ABCB1 (ATP binding cassette subfamily B member modulator zosuquidar dramatically suppresses expression by triggering its autophagic degradation. Mechanistically, interacts with impairs COP II‐mediated...
Abstract Photodynamic therapy is attracting increasing attention, but how to increase its tumor-specificity remains a daunting challenge. Herein we report theranostic probe (azo-PDT) that integrates pyropheophorbide α as photosensitizer and NIR fluorophore for tumor imaging. The two functionalities are linked with hypoxic-sensitive azo group. Under normal conditions, both the phototoxicity of fluorescence inhibited. While under hypoxic condition, reductive cleavage group will restore...
The endocytic trafficking pathway is a highly organized cellular program responsible for the regulation of membrane components and uptake extracellular substances. Molecules internalized into cell through endocytosis will be sorted degradation or recycled back to membrane, which determined by series sorting events. Many receptors, enzymes, transporters on are strictly regulated process, thus has profound effect homeostasis. However, process typically dysregulated in cancers, leads aberrant...
Mevalonate metabolism plays an important role in regulating tumor growth and progression; however, its immune evasion checkpoint modulation remains unclear. Here, we found that non-small cell lung cancer (NSCLC) patients with higher plasma mevalonate response better to anti-PD-(L)1 therapy, as indicated by prolonged progression-free survival overall survival. Plasma levels were positively correlated programmed death ligand-1 (PD-L1) expression tissues. In NSCLC lines patient-derived cells,...
Background The stimulator of interferon genes (STING) signaling pathway has been demonstrated to propagate the cancer-immunity cycle and remodel tumor microenvironment emerged as an appealing target for cancer immunotherapy. Interest in STING agonist development increased, candidates hold significant promise; however, most are still early stages human clinical trials. We found that ABT-199 activated enhance immunotherapeutic effect, provided a ready-to-use small molecule drug activation....
A correlation between metabolic alterations of neuroactive steroids and Alzheimer's disease remains unknown. In the present study, amyloid beta (Aβ) 25-35 (Aβ25-35) injected into bilateral hippocampus CA1 region significantly reduced learning memory. At biochemical level, hippocampal levels pregnenolone were with Aβ25-35 treatment. Furthermore, progesterone was considerably decreased in prefrontal cortex hippocampus, 17β-estradiol elevated. To our knowledge, this is first report showing that...
PD-L1 (programmed cell death ligand 1) is frequently up-regulated in tumors and critical tumor immune escape. In addition to antibodies that block the interaction between PD-1 protein 1), small-molecule compounds suppress expression also exhibit significant anti-tumor effects, emerging as a new strategy targeting PD-L1. By using cell-based screening model, we found butein, natural chalcone compound, significantly reduced cytoplasm surface of This effect was further validated various...