A5101757178- PARP inhibition in cancer therapy
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Bacteriophages and microbial interactions
- Histone Deacetylase Inhibitors Research
- Viral gastroenteritis research and epidemiology
- Neutropenia and Cancer Infections
- Genomics and Phylogenetic Studies
- Phagocytosis and Immune Regulation
- Genital Health and Disease
- Environmental Impact and Sustainability
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Infectious Aortic and Vascular Conditions
- Virus-based gene therapy research
- Aortic Disease and Treatment Approaches
- Cervical Cancer and HPV Research
- Mesenchymal stem cell research
- Biosensors and Analytical Detection
- Carbon and Quantum Dots Applications
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
National Institute for Viral Disease Control and Prevention
2024-2025
Shenzhen Institutes of Advanced Technology
2021-2023
Chinese Academy of Sciences
2015-2023
Air Force Medical University
2023
Henan University of Science and Technology
2021
Zhejiang University
2015-2019
Stomatology Hospital
2016
Research Center for Eco-Environmental Sciences
2015
// Ling Ding 1 , Guikai Liang Zhangting Yao Jieqiong Zhang Ruiyang Liu Huihui Chen Yulu Zhou Honghai Wu Bo Yang Qiaojun He Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute Pharmacology and Toxicology, College Pharmaceutical Sciences, University, Hangzhou 310058, China Correspondence to: He, e-mail: qiaojunhe@zju.edu.cn Keywords: metformin, macrophage polarization, cancer metastasis, AMPKα1 Received: July 05, 2015 Accepted: October...
Although M2-like tumor-associated macrophages (TAMs) have been considered as a vital therapeutic target in cancer therapy due to their role promoting tumor progression and metastasis, very few compounds identified inhibit polarization of TAMs. Here, we showed that Imatinib significantly prevented macrophage induced by IL-13 or IL-4 vitro, illustrated reduced expression cell surface marker CD206 genes, including Arg1, Mgl2, Mrc1, CDH1, CCL2. Further, the migration lung cells promoted...
Abstract Background This study aimed to investigate the epidemiology of high-risk human papillomavirus (HPV) in female population Beijing, China, and identify relationship between HPV genotypes host factors. Methods testing was performed on women aged 15–89 (mean age 38.0 ± 10.9 years) from Beijing 2020. High-risk genotyping real-time polymerase chain reaction used determine genotypes. The overall prevalence, age-specific genotype distribution, correlation cervical cytology were analyzed....
Phage therapy has shown great promise for the treatment of multidrug-resistant bacterial infections. However, lack a thorough and organized understanding phage-body interactions limited its clinical application. Here, we administered different purified phages (
Epstein-Barr virus (EBV) reactivation, a key factor in (EBV)-associated malignancies, is regulated by specific cellular microRNAs (miRNAs). This study investigated the role of Hsa-miR-7974 (miR-7974) this process. miRNA sequencing revealed significant downregulation miR-7974 reactivated EBV-positive cell lines (Raji and C666-1). Bioinformatics prediction dual-luciferase assays confirmed direct targeting EBV immediate-early gene BRLF1 miR-7974. Furthermore, mimics suppressed, whereas...
To determine the effect of combination lapatinib with chlorogenic acid on metastasis breast cancer in mouse model.The classical macrophage M2 polarization model induced by interlukin13in vitro was adopted study. Flow cytometric analysis performed to detect expression marker CD206. The transcription M2-associated genes measured RT-PCR. HE staining used analyze metastatic nodes lungs MMTV-PyVT mice. Immunostaining related proteins cancer.The and inhibited CD206 IL-13[(42.17%±2.59%) vs...
Atrial fibrillation is the most common arrhythmia of clinical significance and hypertension one its major risk factors. This study aimed to evaluate diagnostic accuracy an automated oscillometric blood pressure (BP) monitor with function atrial detection for screening.Patients attending outpatient cardiology clinics were recruited screening by BP triplicate measurements detection. Furthermore, a single-lead ECG was recorded simultaneously comparison as reference standard. The test's...
Varicella‐zoster virus (VZV)‐specific cell‐mediated immunity (CMI) is critical for preventing and controlling the onset of herpes zoster (HZ). To assess VZV CMI, an interferon‐γ (IFN‐γ) enzyme‐linked immunosorbent assay (ELISA) was validated by examining influence VZV‐specific antigen content, incubation time, interval from whole blood collection on assay. In phase II clinical trial, CMI in adults ≥50 years age administered HZ vaccine were evaluated IFN‐γ ELISA, as determined measuring...
Abstract Objectives Phage therapy has shown a great promise for the treatment of multidrug-resistant bacterial infections. However, lack thorough and organized understanding phage-body interactions limited its clinical application. Methods Here, we administered different purified phages ( Salmonella phage SE_SZW1, Acinetobacter AB_SZ6, Pseudomonas PA_LZ7) intravenously to healthy animals (rats monkeys) evaluate phage-induced host responses pharmacokinetics (PK) with intravenous (IV) doses in...
<p>Sequences and primers used in experiment.</p>
<p>PARP1 suppresses the transcription of PD-L1 in various cancer cells.</p>
<p>PARP inhibitors upregulate the protein level of PD-L1.</p>
<p>Various cancer cells are transfected with PARP1 siRNA, and the phosphorylation of STAT3 was upregulated.</p>
<p>Sequences and primers used in experiment.</p>
<p>Increased PD-L1 expression is associated with enhanced STAT3 phosphorylation.</p>
<p>STAT3 is required for Olaparib-induced PD-L1 expression.</p>