A5079292547- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Olfactory and Sensory Function Studies
- Receptor Mechanisms and Signaling
- Electrochemical Analysis and Applications
- Neurotransmitter Receptor Influence on Behavior
- Aging, Health, and Disability
- Cannabis and Cannabinoid Research
- Liver Disease Diagnosis and Treatment
- Trace Elements in Health
- Birth, Development, and Health
- Human Health and Disease
- Biochemical effects in animals
- Photoreceptor and optogenetics research
- Seed and Plant Biochemistry
- Fatty Acid Research and Health
- Microencapsulation and Drying Processes
- Nicotinic Acetylcholine Receptors Study
- Freezing and Crystallization Processes
University of Valparaíso
2016-2025
Valparaiso University
2013
Universidad Católica del Norte
2007-2012
Pontificia Universidad Católica de Chile
2005-2006
University of Chile
2000-2002
Abstract The present study aimed to identify morphological correlates of environment‐induced changes at excitatory synapses the primary auditory cortex (A1). We used Golgi‐Cox stain technique compare pyramidal cells dendritic properties Sprague‐Dawley rats exposed different environmental manipulations. Sholl analysis, length measures, and spine density counts were monitor effects sensory deafness an version enrichment (EE). found that decreased apical leaving basal unchanged, whereas EE...
The mechanism of copper (Cu) neurotoxicity was studied in the RCSN‐3 neuronal dopaminergic cell line, derived from substantia nigra an adult rat. formation a Cu–dopamine complex accompanied by oxidation dopamine to aminochrome. We found that mediates uptake 64 CuSO 4 into Raúl Caviedes nigra‐clone 3 (RCSN3) cells, and it is inhibited addition excess (2 m ) (63%, p < 0.001) nomifensine µ (77%, 0.001). Copper sulfate (1 alone not toxic but when combined with or dicoumarol (95% toxicity;...
Affiliative tactile interactions buffer social mammals against neurobiological and behavioral effects of stress. The aim this study was to investigate the cutaneous mechanisms underlying such beneficial consequences touch by determining whether daily stroking, specifically targeted activate a velocity/force tuned class low-threshold c-fiber mechanoreceptor (CLTM), confers resilience established markers chronic unpredictable mild stress (CMS). Adult male Sprague Dawley rats were exposed 2...
This study investigates the effects of a high-fat diet (HFD) during pregnancy and lactation on maternal offspring health, focusing behavioral, metabolic, fatty acid composition outcomes in rat model. Twelve female Sprague-Dawley rats were fed either control diet, CD (n = 6), or HFD 6) for 12 weeks, encompassing mating, gestation, periods (18 weeks). Anxiety-like behavior, depression-like social play studied. Post mortem, liver function, hepatic steatosis, (erythrocytes, liver, adipose...
Abstract Chronic stress leads to secretion of the adrenal steroid hormone corticosterone, inducing hippocampal atrophy and dendritic hypertrophy in rat amygdala. Both alterations have been correlated with memory impairment increased anxiety. Supplementation ω-3 fatty acids improves learning rats. The aim this study was evaluate effects supplementation on major biological behavioral markers. Male Sprague–Dawley rats were randomly assigned three experimental groups: 1) Control, 2) Vehicle,...
The foetal brain is highly susceptible to stress in late pregnancy, with lifelong effects of on physiology and behaviour. present study aimed determine the physiological behavioural prenatal during prepubertal period female male rats. We subjected pregnant Sprague‐Dawley rats a restraint protocol from gestational day 14 21, critical for susceptibility effects. Male offspring were subsequently assessed at postnatal 24 anxiety‐ depressive‐like behaviours, as well spontaneous social...
Psychosocial stress has increased considerably in our modern lifestyle, affecting global mental health. Deficits attentional control are cardinal features of disorders and pathological anxiety. Studies suggest that changes the locus coeruleus-norepinephrine system could underlie effects on top-down control. However, impact psychosocial processes its underlying neural mechanisms poorly understood. This study aims to investigate effect processing brain signatures. Evoked potentials pupillary...
While chronic stress induces dendritic atrophy in the hippocampus and impairs learning memory, supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) is known to improve memory of control rats. Whether PUFA improves morphology, synaptic transmission, chronically stressed rats remains unknown. In this work, we randomly assigned male Sprague-Dawley four experimental groups: two unsupplemented groups, stress, supplemented groups (DHA EPA mix), + PUFA. Dendritic morphology transmission...
Chronic stress affects brain areas involved in learning and emotional responses. Although most studies have concentrated on the effect of limbic-related structures, this study we investigated whether chronic might induce impairments diencephalic structures associated with limbic components response. Specifically, analyzed immobilization expression sympathetic markers rat epithalamic pineal gland by immunohistochemistry western blot, whereas plasma melatonin concentration was determined...
Brain physiology and morphology are vulnerable to chronic stress, impacting cognitive performance behavior. However, functional compounds found in food may alleviate these alterations. White quinoa (Chenopodium quinoa, Wild) seeds contain a high content of n-3 fatty acids, including alpha-linolenic acid. This study aimed evaluate the potential neuroprotective role quinoa-based (QFF) rats. Prepubertal male Sprague-Dawley rats were fed with rat chow or QFF (50% + 50% dehydrated seeds) exposed...
Research in programming has focused the study of stimuli that affect sensitive periods development such as prenatal and neonatal stage. We previously showed exposure to estradiol valerate female rats during first 12 h life increased catecholamine content ventromedial-arcuatus hypothalamus adult rat. However, changes others dopaminergic circuits have not been studied. The purpose this work was determine neurotransmitters induced by (0.1 mg/50 μl s. c. per rat) administration on nigrostriatal...
Chronic stress is a risk factor for the development of psychiatric disorders, some which involve dysfunction prefrontal cortex (PFC). There higher prevalence these chronic stress-related disorders during adolescence, when PFC has not yet fully matured. In present work we studied effect repeated adolescence on synaptic function in and adulthood. To this end, adolescent Sprague-Dawley rats were subjected to seven consecutive days restraint stress. Afterward, both transmission short- long-term...
Schizophrenia (SZ) is associated with changes in the structure and function of several brain areas. Several findings suggest that these impairments are related to a dysfunction γ-aminobutyric acid (GABA) neurotransmission areas such as medial prefrontal cortex (mPFC), hippocampus (HPC) primary auditory (A1); however, it still unclear how GABAergic system disrupted Here, we examined effect ketamine (Ket) administration during late adolescence rats on inhibition mPFC-, ventral HPC (vHPC) A1....
The perception of music depends on the normal function peripheral and central auditory system. Aged subjects without hearing loss have altered perception, including pitch temporal features. Presbycusis or age-related is a frequent condition in elderly people, produced by neurodegenerative processes that affect cochlear receptor cells brain circuits involved perception. Clinically, presbycusis patients bilateral high-frequency deteriorated speech intelligibility. Music impairments can be...