A5013442752- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Nerve injury and regeneration
- Neuroscience and Neural Engineering
- Gastroesophageal reflux and treatments
- Inflammasome and immune disorders
- Hormonal Regulation and Hypertension
- Dermatology and Skin Diseases
- Adipose Tissue and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Pneumonia and Respiratory Infections
- Endoplasmic Reticulum Stress and Disease
- Neural dynamics and brain function
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Extracellular vesicles in disease
- Ion Transport and Channel Regulation
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- Ion channel regulation and function
- Autoimmune Bullous Skin Diseases
- Chronic Kidney Disease and Diabetes
- Eosinophilic Esophagitis
Consejo Nacional de Investigaciones Científicas y Técnicas
2024
Instituto de Efectividad Clínica y Sanitaria
2024
Pontificia Universidad Católica de Chile
2012-2020
Universidad de Los Andes, Chile
2004-2018
Leibniz Institute for Neurobiology
2017
Universidad de Los Andes
2010-2013
Stress precipitates mood disorders, characterized by a range of symptoms present in different combinations, suggesting the existence disease subtypes. Using an animal model, we previously described that repetitive stress via restraint or immobilization induced depressive-like behaviors rats were differentially reverted serotonin- noradrenaline-based antidepressant drug, indicating neurobiological mechanisms may be involved. The forebrain astrocyte protein aldolase C, contained small...
Abstract The cell adhesion molecule neuroplastin (Np) is a novel candidate to influence human intelligence. Np-deficient mice display complex cognitive deficits and reduced levels of Plasma Membrane Ca 2+ ATPases (PMCAs), an essential regulator the intracellular concentration ([iCa ]) neuronal activity. We show abundant expression conserved cellular molecular features Np in glutamatergic neurons hippocampal-cortical pathways as characterized for rodent brain. In Nptn lox/loxEmx1Cre mice,...
Chronic kidney disease (CKD) is characterized by loss of renal function. The pathological processes involved in the progression this condition are already known, but molecular mechanisms have not been completely explained. Recent reports shown intrinsic capacity to undergo repair after acute injury through reexpression repairing proteins (Villanueva S, Cespedes C, Vio CP. Am J Physiol Regul Integr Comp 290: R861–R870, 2006). Stimulation with basic fibroblast growth factor (bFGF) could...
Abstract Brain‐derived neurotrophic factor (BDNF) and its receptor TrkB are essential regulators of synaptic function in the adult CNS. A TrkB‐mediated effect at excitatory synapses is enhancement NMDA (NMDA‐R)‐mediated currents. Recently, opposing effects pan‐neurotrophin p75 NTR on long‐term depression potentiation have been reported hippocampus. To further study regulation NMDA‐Rs by neurotrophin receptors their native protein environment, we micro‐transplanted rat forebrain post‐synaptic...
Abstract Background Linear IgA bullous dermatosis (LABD) is an acquired autoimmune sub‐epidermal vesiculobullous disease characterized by continuous linear deposit on the basement membrane zone, as visualized direct immunofluorescence microscopy. LABD can affect both adults and children. The very uncommon, with a still unknown incidence in South American population. Materials methods All confirmed cases of histological our hospital were studied. Results three females two males, aged from 8...
Abstract Background Growing evidence shows that atopic dermatitis (AD), food allergy (FA), allergic rhinitis, and asthma are largely determined during the first 1000 days (time elapsed from conception to 2nd birthday). The ARIES birth cohort aims determine prenatal perinatal conditions, as well genetic epigenetic factors, participate in early setting of immune responses, role these later determination risk diseases offspring. Methods We have designed a 250 families with recruitment (~ 14...
Introduction: Aldosterone can induce changes in the expression or activity of Na + /H exchanger isoform 1 (NHE–1) vascular smooth muscle cells. We aimed to clarify whether chronic mineralocorticoid receptor activation exerts an effect on NHE–1 aorta mineralocorticoid-induced hypertensive rats. Methods: Uninephrectomized male Sprague-Dawley rats received subcutaneously 10 mg/week desoxycorticosterone (DOCA) with without 20 mg/kg spironolactone, vehicle alone ( n = 20). After four weeks...