A5102887675- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Ovarian function and disorders
- Extracellular vesicles in disease
- Assisted Reproductive Technology and Twin Pregnancy
- Male Reproductive Health Studies
- Prenatal Screening and Diagnostics
- MicroRNA in disease regulation
- Cystic Fibrosis Research Advances
- Sexual Differentiation and Disorders
- Shoulder Injury and Treatment
- Bee Products Chemical Analysis
- Radiation Effects and Dosimetry
- RNA Research and Splicing
- Tendon Structure and Treatment
- Parasitic Infections and Diagnostics
- Ovarian cancer diagnosis and treatment
- Child Nutrition and Water Access
- Accounting and Financial Management
- Shoulder and Clavicle Injuries
- Sports injuries and prevention
- Nerve injury and regeneration
- Hormonal and reproductive studies
- Nerve Injury and Rehabilitation
- Politics and Society in Latin America
Universidad de Los Andes, Chile
2016-2024
Universidad Andrés Bello
2016-2018
Center for Rheumatology
2013
Hospital Universitario Virgen de las Nieves
1992-2009
Heifer International
2007
Centro Español de Investigación Farmacoepidemiológica
2005
Astrocytes use gliotransmitters to modulate neuronal function and plasticity. However, the role of small extracellular vesicles, called exosomes, in astrocyte-to-neuron signaling is mostly unknown. Exosomes originate multivesicular bodies parent cells are secreted by fusion body limiting membrane with plasma membrane. Their molecular cargo, consisting RNA species, proteins, lipids, part cell type state specific. Among species transported microRNAs (miRNAs) able modify gene expression...
Stress precipitates mood disorders, characterized by a range of symptoms present in different combinations, suggesting the existence disease subtypes. Using an animal model, we previously described that repetitive stress via restraint or immobilization induced depressive-like behaviors rats were differentially reverted serotonin- noradrenaline-based antidepressant drug, indicating neurobiological mechanisms may be involved. The forebrain astrocyte protein aldolase C, contained small...
External quality assessment is essential in modern andrology laboratories. To assess the proficiency of laboratories participating an external programme (EQAP), limits for acceptable variability must be determined. Limits currently specified largely depend on criteria set by organizers individual EQAP schemes. The objective this study was to evaluate different described ISO 13528: 2005 calculating when applied basic semen analysis parameters.The data used were means and standard deviations...
Considerable evidence indicates that adrenal hormones may affect gonadal function. To assess the role of some in human follicular fluid and their relationship with ability oocyte to be fertilized then cleave vitro, cortisol dehydroepiandrosterone sulfate were measured obtained at time recovery for vitro fertilization from cycles stimulated by clomiphene citrate, menopausal gonadotropin chorionic gonadotropin. Thirty-six containing mature oocyte-corona-cumulus complexes free visible blood...
Purpose: The aim of this study is to evaluate in vivo the level apoptosis human rotator cuff tears and relationship it might have with tendon degeneration.Methods: Rotator biopsies from 19 male female patients, ages between 38 68 years, without previous corticosteroid infiltrations were collected via arthroscopy. Biopsies seven patients healthy cuffs used as a control group. An situ terminal deoxynucleotidyl transferase dUTP nick end labeling assay was performed detect apoptosis, which...
Stress is a widespread problem in today's societies, having important consequences on brain function. Among the plethora of mechanisms involved stress response at molecular level, role microRNAs (miRNAs) beginning to be recognized. The control gene expression by these noncoding RNAs makes them essential regulators neuronal and synaptic physiology, alterations their levels have been associated with pathological conditions mental disorders. In particular, excitatory (i.e., glutamate-mediated)...
This study was undertaken to evaluate the relationship between concentrations of insulin and insulin-like growth factor I (IGF-I) in follicular fluid fertilization cleavage human oocytes fertilized vitro. The concentration oestradiol, progesterone, luteinizing hormone, follicle-stimulating testosterone, IGF-I determined 36 fluids, free visible blood contamination containing mature oocyte-corona-cumulus complexes, obtained from 12 women undergoing vitro fertilization. Follicular development...
The aim of this study was to identify analytical quality specifications for seminal parameters based on clinicians' opinions, and compare with those biological variability state the art.Two questionnaires case histories were sent laboratories participating in Spanish programme external semen analysis distribution as many specialist clinicians possible. Our intention determine critical difference (CD), defined needed between two consecutive results obtained from be 95 % confident that...
Abstract The regenerative potential of developing cortical axons following injury depends on intrinsic mechanisms, such as axon-autonomous protein synthesis, that are still not fully understood. An emerging factor in this process is the bi-directional interplay between microtubule dynamics and structural proteins axonal endoplasmic reticulum. Therefore, we hypothesize locally synthesized reticulum may regulate outgrowth injured axons. This hypothesis supported by RNA data-mining, which...
Summary. The ability to induce sperm acrosome reaction by follicular fluid is neither correlated with the stimulation regimen nor in vitro fertilization outcome.
<h3>Background</h3> Up to 35% of patients with shoulder pain have a full-thickness rotator cuff tear. It has been proven deleterious effect corticosteroid on collagen. However, the influence injection in incidence tears is unknown. <h3>Objectives</h3> The aim this study was evaluate risk Secondary outcomes were tear between partial-thickness and improvement function. <h3>Methods</h3> Prospective, open-label study. Patients unilateral painful without previous local steroid recluted. Clinical...