A5019883795- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Hormonal and reproductive studies
- Pituitary Gland Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Health Promotion and Cardiovascular Prevention
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Thermal Regulation in Medicine
- Adrenal and Paraganglionic Tumors
- Salivary Gland Disorders and Functions
- Cancer, Hypoxia, and Metabolism
- Lipoproteins and Cardiovascular Health
- Intensive Care Unit Cognitive Disorders
- Cancer Risks and Factors
- Bioinformatics and Genomic Networks
- Advanced Neuroimaging Techniques and Applications
- Sexual Differentiation and Disorders
- Functional Brain Connectivity Studies
- Advanced Biosensing Techniques and Applications
- Sepsis Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Traditional Chinese Medicine Studies
University of Manchester
2009-2024
Athens Medical Center
2023
LMC Diabetes & Endocrinology (Canada)
2008-2018
University General Hospital Attikon
2012-2015
Evangelismos Hospital
2012
The Christie Hospital
2009-2011
Manchester Academic Health Science Centre
2010
Cardiovascular Research Center
2008-2010
Salivary cortisol measurement is used as a practical surrogate for serum free cortisol. However, parotid tissue harbors 11β-hydroxysteroid dehydrogenase (11β-HSD2) activity converting to cortisone.This study was designed assess the impact of 11β-HSD2 on salivary PATIENTS, DESIGN, AND OUTCOME MEASURES: Study participants with changes in circulating corticosteroid-binding globulin (CBG) (±oral contraceptive, functionally CBG null) and controls were studied during adrenal stimulation by ACTH...
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) eliminates cross-reactivity, which is a major limitation of immunoassays used for the measurement salivary cortisol (SalC). We aimed to evaluate potential SalC measured by LC-MS/MS in patients undergoing assessment HPA axis.Cross-sectional study 78 admitted routine testing specialized endocrine unit.Matched serum and saliva samples were collected from 68 who had short synacthen test (SST, 250 mcg im) 10 an insulin tolerance (ITT, 0.15...
The treatment of subclinical hypercortisolism in patients with bilateral adrenal incidentalomas (AI) is debatable. We aimed to compare the biochemical and clinical outcome unilateral adrenalectomy vs a conservative approach these patients.Retrospective study.The study included 33 AI; 14 underwent largest lesion (surgical group), whereas 19 were followed up (follow-up group). At baseline at each follow-up visit, we measured 0800 h plasma ACTH, midnight serum cortisol (MSF), 24-h urinary-free...
Summary Objective Corticosteroid‐binding globulin (CBG) is the principal carrier for cortisol in circulation. Variations CBG‐binding capacity are predicted to alter total serum disposition, but free believed be unaffected. Unbound pharmacokinetics (PK) have not been studied context of CBG changes. We aimed assess regulation PK by CBG. Design and subjects Women on oestrogens [oral contraceptive pill, (OCP)], patients homozygous a nonfunctioning variant (CBG null) healthy controls (HV) were...
Corticosteroid-binding globulin (CBG) is the principal carrier for glucocorticoids in circulation and a regulator of their bioavailability. Inherited CBG deficiencies are rarely reported, only three causative mutations four families have been described.In 26-yr-old female with hypotension, fatigue, undetectable total serum cortisol at presentation, we identified novel homozygous c.776g>t transversion exon 3 (SERPINA6) gene. This results p.Gly237Val substitution that predicted to influence...
Corticosteroid-binding globulin (CBG) is the principal carrier of natural glucocorticoids in circulation, and we hypothesized that it modulates glucocorticoid bioactivity (GBA). Alterations CBG, presence noncortisol, naturally occurring use potent, synthetic glucocorticoids, all make difficult to assess adrenal activity in-vivo; these problems can be addressed by a bioassay.A bioassay was developed for serum GBA physicochemical ultrafiltration-liquid chromatography-tandem mass spectrometry...
Corticosteroid-binding globulin (CBG), encoded by SERPINA6, is the principal plasma binding protein for cortisol. Most nonsynonymous single-nucleotide polymorphisms that alter production or function of CBG occur rarely, and their clinical significance remains obscure.Serum DNA were obtained from a Greek woman with low morning cortisol levels family members. SERPINA6 exons sequenced, serum was measured ELISA cortisol-binding capacity assay. Recombinant variants produced detailed functional...
Purpose: Lipid lowering treatments (LLTs) can reduce the risk of atherosclerotic cardiovascular disease (ASCVD). Despite availability potent LLTs, our clinical observations suggest an inadequate use such agents. To evaluate this treatment deficit, we designed present study. Methods: We reviewed charts all patients with a history ASCVD (coronary artery disease—CAD; carotid stenosis—CS; or peripheral disease—PAD) diagnosed prior to their first visit one clinics. recorded gender, age, factors...
Purpose: This study aimed to evaluate various therapeutic approaches, identify potential predictive factors for the recurrence and development of hypothyroidism, examine specific clinical laboratory characteristics patients with subacute thyroiditis (SAT) due SARS-CoV-2 infection. Methods: We retrospectively analyzed medical records 226 confirmed SAT diagnosed from January 2020 November 2022. Results: The mean age was 48.01 ± 0.75 years, F/M ratio 2.3/1. At end follow-up period, 69 (32.1%)...
ABSTRACT Context Estimated rates of cortisol elimination and appearance vary according to the model used obtain them. Generalizability current models disposition in healthy humans is limited. Objective Development validation a realistic, mechanistic that accounts for major factors influencing plasma concentrations vivo (Model 4), comparison previously described clinical use (Models 1-3). Methods The four were independently applied concentration data obtained hydrocortisone bolus experiment...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Disclosure: R.D. Paparodis: None. E. Karvounis: A. Kapezanou: D. Bantouna: S. Livadas: G. Simeakis: D.P. Askitis: I. Androulakis: N.G. Angelopoulos: Zianni: Perogamvros: Boniakos: Rizoulis: Imam: J.C. Jaume: Introduction: Thyroid peroxidase (TPO) antibodies are a form of humoral immunity. We recently found that high TPO antibody titers tend to limit the expansion/progression thyroid cancers follicular origin (TCFO).[1] Many studies report opposite trend, mostly for indolent TCFO....
Abstract Disclosure: R.D. Paparodis: None. E. Karvounis: A. Kapezanou: D. Bantouna: S. Livadas: G. Simeakis: D.P. Askitis: I. Androulakis: N.G. Angelopoulos: Zianni: Perogamvros: Boniakos: Rizoulis: Imam: J.C. Jaume: Introduction: Thyroid peroxidase (TPO) antibodies are a form of humoral immunity. We recently found that high TPO antibody titers tend to limit the expansion/progression thyroid cancers follicular origin (TCFO).1 Many studies report opposite trend, mostly for indolent TCFO....
Abstract Disclosure: R.D. Paparodis: None. E. Karvounis: A. Kapezanou: S. Livadas: G. Simeakis: D.P. Askitis: I. Androulakis: N.G. Angelopoulos: D. Zianni: Rizoulis: Boniakos: Perogamvros: Bantouna: J.C. Jaume: Introduction: Diabetes has been linked to increased risk for several cancers and aggressiveness of tumor behavior. A link between thyroid cancer diabetes appears controversial in the literature as yet. We designed present study assess whether autoimmune (type 1 + LADA = DM1) or type 2...
Abstract Disclosure: R.D. Paparodis: None. E. Karvounis: A. Kapezanou: S. Livadas: G. Simeakis: D.P. Askitis: I. Androulakis: N.G. Angelopoulos: D. Zianni: Rizoulis: Boniakos: Perogamvros: Bantouna: J.C. Jaume: Introduction: Diabetes has been linked to increased risk for several cancers and aggressiveness of tumor behavior. A link between thyroid cancer diabetes appears controversial in the literature as yet. We designed present study assess whether autoimmune (type 1 + LADA = DM1) or type 2...
Abstract Disclosure: R.I. Dorin: None. I. Perogamvros: C.R. Qualls: Background: The relationship between serum concentrations of total (XTotF) and free (XF) cortisol (test tube equilibrium at 37°C) is influenced by many factors. These include affinities binding proteins (BP), such as CBG albumin (A). Among women taking oral contraceptives (OC), XF was found to be higher than predicted using ligand-BP association parameters developed in healthy volunteers (HV). We hypothesized that ligand(s)...
6.3%), the peak GH was 3 ng/ml or less.Mean baseline (n ϭ 127) 1.47 Ϯ 2.58 ng/dl, and eight of 120 (6.8%) showed an insufficient IGF-I response (Ͻ50% over baseline) to generation test.Conclusion: FM patients show a high prevalence axis dysfunction.A significant number biochemical patterns deficiency as well some degree resistance might be potential candidates for substitution treatment.
Abstract Background: Corticosteroid-binding globulin (CBG) is the principal carrier for glucocorticoids in circulation and a regulator of their bioavailability. Inherited CBG deficiencies are rarely reported, only three causative mutations four families have been described. Patients, Methods, Results: In 26-yr-old female with hypotension, fatigue, undetectable serum cortisol at presentation, we identified novel homozygous c.776g>t transversion exon 3 (SERPINA6) gene. This results...