A5049184270- Circadian rhythm and melatonin
- Gene Regulatory Network Analysis
- Stress Responses and Cortisol
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Computational Drug Discovery Methods
- Heart Rate Variability and Autonomic Control
- Spaceflight effects on biology
- Microbial Metabolic Engineering and Bioproduction
- Advanced Combustion Engine Technologies
- Immune Response and Inflammation
- Advanced Optimization Algorithms Research
- Economic theories and models
- Combustion and flame dynamics
- Adipose Tissue and Metabolism
- Optimization and Search Problems
- Advanced Control Systems Optimization
- Hormonal Regulation and Hypertension
- Metabolomics and Mass Spectrometry Studies
- Pharmacogenetics and Drug Metabolism
- Thyroid Disorders and Treatments
- Dietary Effects on Health
- Genetics, Aging, and Longevity in Model Organisms
- Adrenal Hormones and Disorders
- Process Optimization and Integration
Quantitative BioSciences
2025
Johnson University
2013-2024
Rutgers, The State University of New Jersey
2015-2024
Athens Medical Center
2022-2023
Gorgias Press (United States)
2023
Brunswick (United States)
2022
Metropolitan Hospital
2018-2019
Rutgers Sexual and Reproductive Health and Rights
2011-2017
United States Military Academy
2016
General Hospital of Athens G. Genimatas
2009-2016
Cancer is a devastating disease that takes the lives of hundreds thousands people every year. Due to heterogeneity, standard treatments, such as chemotherapy or radiation, are effective in only subset patient population. Tumors can have different underlying genetic causes and may express proteins one versus another. This inherent variability cancer lends itself growing field precision personalized medicine (PPM). There many ongoing efforts acquire PPM data order characterize molecular...
Stem cells that adopt distinct lineages cannot be distinguished based on traditional cell shape. This study reports higher-order variations in shape and cytoskeletal organization occur within hours of stimulation forecast the lineage commitment fates human mesenchymal stem (hMSCs). The unique approach captures numerous early (24 h), quantitative features actin fluororeporter shapes, intensities, textures, spatial distributions (collectively termed morphometric descriptors). large number...
Abstract Two novel deterministic global optimization algorithms for nonconvex mixed‐integer problems (MINLPs) are proposed, using the advances of αBB algorithm NLPs Adjiman et al. The special structure (SMIN‐αBB) addresses with nonconvexities in continuous variables and linear mixed‐bilinear participation binary variables. general (GMIN‐αBB) is applicable to a very class which relaxation twice continuously differentiable. Both developed concepts branch‐and‐bound, but they differ their...
The laminar burning velocities of 45 hydrocarbons have been investigated in a constant volume combustion vessel at elevated temperature and pressure. mixtures are ignited the center spherical an initial 450 K pressure 304 kPa. Data acquired over stoichiometry range 0.55 ≤ φ 1.4. velocity is determined from thermodynamic analysis vs. time data. results for alkanes alkenes consistent with trends previously identified literature, i.e., faster than corresponding alkane same carbon connectivity....
Monitoring the change in expression patterns over time provides distinct possibility of unraveling mechanistic drivers characterizing cellular responses. Gene arrays measuring level mRNA thousands genes simultaneously provide a method high-throughput data collection necessary for obtaining scope required understanding complexities living organisms. Unraveling coherent complex structures transcriptional dynamics is goal large family computational methods aiming at upgrading information...
Differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes requires extensive changes in gene expression, which are partly mediated by post-translational modifications nucleosomal histones. An essential modification for differentiation is the removal acetyl groups from lysine residues catalyzed histone deacetylases (HDACs). The transcriptional targets HDAC activity within OPCs however, have remained elusive and been identified this study interrogating...
Inflammation is a highly complex biological response evoked by many stimuli. A persistent challenge in modeling this dynamic process has been the (nonlinear) nature of that precludes single-variable assumption. Systems-based approaches offer promising possibility for understanding inflammation its homeostatic context. In order to study underlying complexity acute inflammatory response, an agent-based framework developed models emerging host as outcome orchestrated interactions associated...
Two recent, independent, studies conducted novel metabolomics analyses relevant to human sepsis progression; one was a model of endotoxin (lipopolysaccharide (LPS)) challenge (experimental endotoxemia) and the other community acquired pneumonia outcome diagnostic study (CAPSOD). The purpose present assess concordance metabolic responses LPS community-acquired sepsis.We tested hypothesis that patterns response elicited by would agree with those in clinical sepsis. Alterations plasma...
Circadian rhythmicity in mammals is primarily driven by the suprachiasmatic nucleus (SCN), often called central pacemaker, which converts photic information of light and dark cycles into neuronal hormonal signals periphery body. Cells peripheral tissues respond to these centrally mediated cues adjusting their molecular function optimize organism performance. Numerous systemic orchestrate rhythmicity, such as feeding, body temperature, autonomic nervous system, hormones. We propose a...