A5037572372- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Ovarian function and disorders
- Head and Neck Anomalies
- Vitamin D Research Studies
- Lipoproteins and Cardiovascular Health
- Thyroid and Parathyroid Surgery
- Reproductive Biology and Fertility
- Bone health and osteoporosis research
- BRCA gene mutations in cancer
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Growth Hormone and Insulin-like Growth Factors
- Health Promotion and Cardiovascular Prevention
- Cancer, Lipids, and Metabolism
- Hormonal and reproductive studies
- Public Health in Brazil
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Hair Growth and Disorders
- Healthcare cost, quality, practices
- Salivary Gland Tumors Diagnosis and Treatment
- Birth, Development, and Health
- Diabetes Management and Research
- Radiomics and Machine Learning in Medical Imaging
Loyola University Medical Center
2024-2025
Edward Hines, Jr. VA Hospital
2023-2025
Loyola University Chicago
2023-2025
University of Toledo
2014-2024
Loyola Medicine
2024
University of Toledo Medical Center
2019-2023
Ohio University
2019-2023
ProMedica Russell J. Ebeid Children's Hospital
2020
University of Wisconsin–Madison
2013-2014
Northwestern University
2011
Background: Hashimoto's thyroiditis (HT) has been found to coexist with differentiated thyroid cancer (DTC) in surgical specimens, but an association between the two conditions discounted by medical literature. Therefore, we performed this study determine any potential relationship HT and risk of developing DTC. Methods: We collected data for thyrotropin (TSH), thyroxine (T4), peroxidase antibody (TPO-Ab) titers, pathology, weight-based levothyroxine (LT4) replacement dose patients who were...
<h3>Background</h3> Thyroid cancer and thyroid autoimmunity are considered opposite extremes of immune-responses. However, several studies have suggested that coexists with autoimmune diseases like Hashimoto Thyroiditis (HT) Graves disease (GD). We shown the risk developing is higher in patients a silent form -Euthyroid Thyroiditis-(EHT). <h3>Methods</h3> analyzed data from 2633 consecutive GD, HT, EHT non-Autoimmune Disease (Non-AITD) for presence Differentiated Cancer (DTC). further...
Thyroid cancers are usually surrounded by a significant number of immune-reactive cells. Tumor-associated lymphocytes as well background lymphocytic thyroiditis frequently mentioned in pathology reports patients who have undergone surgery for thyroid cancer. The nature this reaction is not understood. fact that cancer can survive adverse microenvironment indicative immune regulation. We characterized the infiltration accompanies and compared it with present autoimmunity. found...
Background/Objectives: Structural incomplete response (SIR) (persistence/recurrence) may occur in 2–6% of low-risk differentiated thyroid cancer (DTC)-cases and 67–75% high risk. Regarding locoregional disease, surgery is the optimal therapeutic modality if smallest dimension targeted node ≥8 mm or ≥10 (central lateral compartment). In presence smaller nodes, contraindications patient’s unwillingness for reoperation, active surveillance (AS) minimally invasive treatments (MITs) be...
Background/Objectives: Vitamins D and B12 play a crucial role in maintaining bone health, immune function, neurological integrity. Combined deficiencies these vitamins can lead to severe health consequences. Current treatment approaches, such as dietary changes single-vitamin supplementation, often fail address comprehensively. This study evaluates the effectiveness of concurrent vitamin supplementation correct insufficiencies. Methods: A prospective, multicenter, randomized controlled trial...
The generation of functionally active, stable T regulatory cells (Tregs) is a crucial target type 1 diabetes (T1D) immunotherapy. This study investigated therapeutic intervention for T1D/Latent autoimmune in adults (LADA), wherein the diabetogenic proinflammatory Treg (intermediate) cell subset was characterized and driven to phenotype (CD4+CD25+FOXP3+). involved simultaneous inhibition eukaryotic initiation factor 5a (eIF5a) Notch pathways using GC7 (N1-Guanyl-1,7-diaminoheptane) Anti-DLL4...
Background: Incidental finding of differentiated thyroid microcarcinomas (DTMc) in patients undergoing surgery for benign indications has become increasingly common. Even though carcinogenesis might relate to the background disease gland, incidence DTMc setting various disorders remains unclear. We designed present study address this question. Materials and Methods: reviewed data from two prospectively collected databases consecutive high-volume tertiary care referral centers, one United...
Background: Parathyroid adenoma is the most common cause of hypercalcemia and rarely leads to a hypercalcemic crisis, which an unusual endocrine emergency that requires timely surgical excision. Case presentation: A 67-year-old male was admitted ER Euroclinic Hospital, Athens, Greece, because elevated calcium levels palpable right-sided neck mass, were accompanied by symptoms nausea, drowsiness, weakness for six months increased prior our evaluation. gradual creatinine elevation decreasing...
Polycystic ovary syndrome confers an increased risk for type 2 diabetes in affected women as early adolescence. First-degree relatives (FDRs) of are at associated reproductive and metabolic phenotypes. We sought to prospectively assess insulin sensitivity secretion measure hormone levels using sensitive techniques. Twelve premenarchal FDR girls 10 control comparable age, Tanner stage, body mass index were studied academic medical center. Frequently sampled intravenous glucose tolerance tests...
Are there abnormalities in gonadotrophin secretion, adrenal steroidogenesis and/or testicular brothers of women with polycystic ovary syndrome (PCOS)? Brothers PCOS have increased responses to releasing hormone (GnRH) agonist stimulation and alterations gonadal steroidogenesis. is a complex genetic disease. Male as well female first-degree relatives reproductive features the syndrome. We previously reported that affected elevated circulating dehydroepiandrosterone sulfate levels. This was...
Background Thyroid nodules are an extremely common entity, and surgery is considered the ultimate diagnostic strategy in those with unclear malignant potential. Unfortunately, strategies aiming to predict risk of malignancy have inadequate specificity. Our group recently found that microenvironment thyroid cancer characterized by enhanced immune invasion activated response mediated double-negative T lymphocytes (DN T) (CD3 + CD4 - CD8 ), which believed enable or promote tumorigenesis. In...
Certain nutraceuticals, mainly containing red yeast rice, might be considered as an alternative therapy to statins in patients with dyslipidemia, although there is still insufficient evidence available respect long-term safety and effectiveness on cardiovascular disease prevention treatment. The aim of this study was assess the lipid-lowering activity a dietary supplement low dose monacolin K combined coenzyme Q10, grape seed olive tree leaf extracts mild hypercholesterolemia. In total, 105...
Purpose: Lipid lowering treatments (LLTs) can reduce the risk of atherosclerotic cardiovascular disease (ASCVD). Despite availability potent LLTs, our clinical observations suggest an inadequate use such agents. To evaluate this treatment deficit, we designed present study. Methods: We reviewed charts all patients with a history ASCVD (coronary artery disease—CAD; carotid stenosis—CS; or peripheral disease—PAD) diagnosed prior to their first visit one clinics. recorded gender, age, factors...