A5051756509- Endodontics and Root Canal Treatments
- Dental Radiography and Imaging
- Dental materials and restorations
- dental development and anomalies
- Oral microbiology and periodontitis research
- Oral and Maxillofacial Pathology
- Cleft Lip and Palate Research
- Dental Erosion and Treatment
- Dental Implant Techniques and Outcomes
- Engineering Technology and Methodologies
- Cancer Cells and Metastasis
- Periodontal Regeneration and Treatments
- Bone Metabolism and Diseases
- Drilling and Well Engineering
- Orthodontics and Dentofacial Orthopedics
- Dental Trauma and Treatments
- Lymphatic System and Diseases
- Occupational health in dentistry
- Pancreatic and Hepatic Oncology Research
- 3D Printing in Biomedical Research
- Genomic variations and chromosomal abnormalities
- Connective tissue disorders research
- COVID-19 diagnosis using AI
- Oral and Craniofacial Lesions
- Congenital limb and hand anomalies
Universidade de São Paulo
2017-2025
University of Portland
2024-2025
Universidade de Ribeirão Preto
2017-2024
OHSU Knight Cancer Institute
2024
Hospital Universitário da Universidade de São Paulo
2023
A hallmark of chronic and inflammatory diseases is the formation a fibrotic stiff extracellular matrix (ECM), typically associated with abnormal, leaky microvascular capillaries. Mechanisms explaining how microvasculature responds to ECM alterations remain unknown. Here, we used microphysiological model capillaries on chip mimicking characteristics healthy or collagen test hypothesis that perivascular cells mediate response vascular mechanical structural changes in human ECM. Capillaries...
Objectives This study assessed the incidence and variability features of root canals system (RCS) their ramifications according to Pucci & Reig (PR) (1944) American Association Endodontists (AAE) (2017) by micro-computed tomography (μCT). Methodology 500 representative extracted human teeth each tooth group (n=50) (maxillary/mandibular central lateral incisors, canines, first second premolars molars) were scanned μCT with a resolution 26.70 μm. The reconstructed cross-sections images...
To evaluate the push-out bond strength of adjustable fiberglass post system to dentin. Twenty maxillary canine roots were endodontically treated and divided into two groups (n=10): conventional posts (CFPs) with single (SAP) system. Two slices each third subjected failure pattern test most apical slice was analysis adhesive interface by scanning electron microscopy (SEM). Data analyzed three-way variance, Tukey, Friedman tests, linear regression (α=0.05). The results showed higher in initial...
To investigate the influence of remaining volume a new intracanal medication based on bioceramic compounds bond strength (BS) and formation an adhesive interface between calcium silicate-based epoxy resin-based root canal sealers. For this purpose, specimens were distributed according to (n = 26): Bio-C Temp (BCT) Ultracal XS (UXS). The roots scanned in microCT, after 7 days, was removed. Then scan performed evaluate remaining. Subsequently, 40 redistributed into 2 subgroups 10) filled...
This study aimed to assess the association between genetic polymorphisms in BMP2 (rs1005464 and rs235768), BMP4 (rs17563), SMAD6 (rs2119261 rs3934908) RUNX2 (rs59983488 rs1200425) pulp stones (PS). A total of 117 participants, consisting 63 individuals with PS 54 without PS, were included. Digital radiographs a demographic/clinical questionnaire used. Genomic DNA from salivary cells was genotyped via real-time polymerase chain reaction. Statistical analyses, including Chi-Square, Fisher's...
This study evaluated the osteogenic potential of bioactive glasses SinGlass (45S5) and High (F18) in regenerating critical bone defects rat calvaria. Both biomaterials promoted new formation around particles, with group exhibiting a higher rate maturation. Histomorphological birefringence analyses revealed better organization newly formed biomaterial-treated groups, immunohistochemistry indicated expression markers such as osteocalcin, immunostaining for morphogenetic protein 2 (BMP 2), 4...
Objective: To evaluate the association between genetic polymorphisms in SOD2 and SOD3 oral health-related quality of life (OHRQoL). Material methods: The cohort study included 109 participants, all whom underwent root canal treatment on a single-rooted maxillary or mandibular tooth with asymptomatic periapical periodontitis. OHRQoL was assessed using Oral Health Impact Profile-14 at three intervals: prior to (T0), 7 (T7), 30 (T30) days post-treatment. Genomic DNA extracted from buccal cells...
To evaluate the shaping ability of several heat-treated nickel-titanium systems used to prepare root canals with moderate and severe curvature, in extracted mandibular molars, by micro-computed tomography, considering their variation kinematics design.
Objective: To evaluate the effect of ultrasonic and sonic activation on physicochemical properties AH Plus, MTA Fillapex, ADSeal, GuttaFlow Bioseal, 2 sealers. Methodology: Three experimental groups were formed: no (NA), (UA), (SA). The sealers manipulated according to manufacturers' instructions. A 3-mL syringe was adapted receive 1 mL sealer. Activation performed with a 20/.01 insert (20 s/1W) in UA group. size 35.04 tip used s/10,000 cycles/min-1) SA molds for analysis filled evaluated...
The aim of this study is to evaluate if single nucleotide polymorphisms (SNPs) in WNT6 and WNT10A are associated with the risk dental pulp calcification orthodontic patients. This cross-sectional followed “Strengthening Reporting Genetic Association Studies” (STREGA) guidelines. Panoramic radiographs (pre- post-orthodontic treatment) genomic DNA from 132 patients were studied. Dental (pulp stones and/or space narrowing) was recorded upper lower first molars. SNPs ( rs7349332 , rs3806557...
To investigate if 5-LO selective inhibitor (MK-886) could be used for systemic treatment of experimentally induced apical periodontitis in a mouse model.Twenty-four C57BL/6 mice were used. After coronal opening, solution containing Escherichia coli LPS (1.0 µg/µL) was inoculated into the root canals lower and upper right first molars (n = 72 teeth). 30 days established, animals treated with MK-886 (5 mg/kg), inhibitor, 7 14 days. The tissues removed histopathological histometric analyses,...
Tooth agenesis is a common congenital anomaly in humans and more oral cleft patients than the general population. Many previous studies suggested that tooth share similar genetic background. Therefore, this study explored association between isolated polymorphisms genes are crucial for craniofacial development. Panoramic radiographs, anamnesis, genomic DNA from 273 were included. Patients classified as present, when at least one permanent was congenitally missing. with syndromes excluded....
Abstract Purpose Mandibular retrognathism (MR) is a common skeletal malocclusion in humans with strong genetic component. Single nucleotide polymorphisms (SNPs) genes encoding epidermal growth factor (EGF) and EGF receptor (EGFR) could be involved the etiology of mandibular retrognathism. Therefore, this study, we investigated whether SNPs for EGFR are associated MR German teenagers. Methods This nested case–control study evaluated orthodontic patients, aged 10–18 years. DNA, which was...
Abstract A wide range of conditions, including chronic inflammatory diseases and cancer, are characterized by the fibrotic microarchitecture increased stiffness collagen type I extracellular matrix. These conditions typically accompanied altered vascular function, vessel leakiness, abnormal capillary morphology stability. The dynamic cell-matrix interactions that regulate function in healthy tissues have been well documented. However, our understanding how gradual mechanical structural...
Human sexual dimorphism is associated with many biological characteristics, including dental variables. To investigate if molars fused roots present sex-associated differences. Panoramic radiographs were used to the frequency and distribution of permanent roots. Only patients all first second included. Third not investigated. Any molar apical usual furcal position considered Comparisons between males females performed using chi-square or Fisher's Mann-Whitney tests established alpha was 5%...