A5016963319- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Cancer and Skin Lesions
- Drug-Induced Adverse Reactions
- Dermatology and Skin Diseases
- Systemic Lupus Erythematosus Research
- Antifungal resistance and susceptibility
- Ocular Diseases and Behçet’s Syndrome
- Fungal Infections and Studies
- Eosinophilic Disorders and Syndromes
- Occupational exposure and asthma
- Allergic Rhinitis and Sensitization
- Autoimmune and Inflammatory Disorders
- Cutaneous lymphoproliferative disorders research
- Food Allergy and Anaphylaxis Research
- Antimicrobial agents and applications
- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Immunodeficiency and Autoimmune Disorders
- Blood properties and coagulation
- Cutaneous Melanoma Detection and Management
- Oral Health Pathology and Treatment
- Psoriasis: Treatment and Pathogenesis
Saiseikai Ibaraki Hospital
2020-2023
Mito Saiseikai General Hospital
2006-2018
National Rehabilitation Center for Persons with Disabilities
2017
Nagoya University Hospital
2006
National Hospital Organization Mito Medical Center
2003
University of Tsukuba
1995-1999
Advanced Dermatology
1996-1999
Futaba (Japan)
1999
Mito Red Cross Hospital
1992-1995
The University of Tokyo
1989-1992
Primary chronic glomerulonephritis is the most common cause of end-stage renal failure in Japan. The incidence dialysis patients Japan about four times higher than United States for reason which are unclear. We conducted a nationwide survey on natural history and treatment primary under program project from Ministry Health Welfare entitled ‘Progressive Chronic Renal Disease’. analyzed patient characteristics, disease onset, clinical data, histological findings 1,850 with 53 institutions 1985...
This study was conducted to investigate the effect of intracerebroventricular administration endothelin (EDT), a novel potent vasoconstricting peptide, on blood pressure in conscious rats. The lateral cerebral ventricle male Wistar rats cannulated, and femoral artery also cannulated measure mean arterial (MABP) heart rate (HR). EDT dissolved 10 microliters artificial cerebrospinal fluid (ACSF) (8.25-66 pmol icv) provoked dose-dependent increase MABP. increased HR, although 66 variable....
Drug-induced pemphigus (DIP) shows clinical, histopathological and immunological features of pemphigus. However, little is known about profiles in DIP.To characterize clinical patients with DIP.We studied 17 Japanese DIP who were treated at Kurume University Hospital or consulted from other hospitals between 1997 2012. Complicated diseases, manifestations, responsible drugs findings immunofluorescence, enzyme-linked immunosorbent assays (ELISAs), immunoblotting (IB) prognosis analysed.Eight...
We report 19 patients who developed extensive patchy or linear erythema on both sides of the buttocks, back and posterior areas thighs within a few days following operations cardioangiography. The was sometimes deeply infiltrative also accompanied by bullae erosion. Patch tests were strongly positive for 10% povidone-iodine (PVP-I, Isodine) solution; however, they negative PVP-I solution with same amount 8% sodium thiosulfate 5% potassium iodide in petrolatum. In all control individuals,...
日常生活動作・活動 (ADL: Activities of daily living) の評価に関して, 老年者一般に適用しうることを目的として, 評価法試案 (ADL-20) を作成し, 大学病院対象110例, 長期入院・入所施設対象106例の合計216例 (男性77例, 女性139例, 平均年齢76.2歳) に施行して, その信頼性, 妥当性, 有用性について検討した. 本評価法は下位領域として基本的ADL (BADL), 手段的ADL (IADL), コミュニケーションADL (CADL) を含む20項目からなり, それぞれ能力を完全自立(3)~全介助(0)までの4段階に分類評価した. 信頼性に関して, 40例について異なる評価者 (医師と理学療法士) による同時評価の一致率を検討した. 全体での完全一致率は85.6%で, 項目毎には70.0~97.5%であり, 一致性の指標としての kappa 係数は0.52~0.88に分布した. 医師と理学療法士間の成績の相関係数は0.97であった. 各項目の内的整合性に関する Cronbach...
Abstract Background Atopic dermatitis develops as a result of complex interactions between several genetic and environmental factors. To date, 4 genome-wide linkage studies atopic have been performed in Caucasian populations, however, similar not done Asian populations. The aim this study was to identify chromosome regions linked Japanese population. Methods We used high-density, single nucleotide polymorphism genotyping assay, the Illumina BeadArray Linkage Mapping Panel (version 4)...
Abstract Pyoderma gangrenosum ( PG ) is a chronic inflammatory disease of unknown cause that presents as an and ulcerative disorder the skin. often associated with underlying systemic disease. However, frequencies diseases are unclear in Japanese patients. In this retrospective, observational study, all patients diagnosed who visited dermatology departments nine regional hospitals around Ibaraki Prefecture were collected from 1982 to 2011 or 2014. The diagnoses based on characteristic...
Hydroxylase cofactor, monoamine neurotransmitters and their metabolites were measured in ischemic rat brain produced by four-vessel occlusion for 30 60 min periods. Slight reduction of hydroxylase cofactor activity was observed the cortex after min. Dopamine increased brainstem, its metabolites, 3,4-dihydroxyphenylacetic acid homovanillic acid, throughout brain. Decrease norepinephrine whole serotonin increase 5-hydroxyindoleacetic a metabolite serotonin, cerebral cortex. The present study...
REPORT OF A CASE 30-year-old Japanese man first noticed a small, slightly pruritic nodule on the dorsum of his left hand in December 1993. Before patient presented to us May 1994 he was treated by personal physician, who prescribed several antibiotics for 2 months without apparent response. The slowly grew and became tender. Another small then appeared forearm. had kept tropical fish 5 years reported injuring when cleaning tank. physical examination revealed dark, erythematous, elevated...
The efficacy of squaric acid dibutylester (SADBE), a topical allergen, was investigated in the treatment 20 patients with warts. All had multiple or warts recalcitrant to other therapies hesitated have painful cryotherapy. present for mean 15.3 months (range 1–36) were successfully sensitized 2% SADBE acetone. Then treated 0.1 0.01% application once week every week, so as maintain mild contact dermatitis. Twelve (60%) completely cured after an average 6 applications 2–12). Five (25%) showed...
We present the repeated clinical, histologic, immunohistochemical, and ultrastructural observations on a cutaneous myofibromatous tumor over 20-month period. A 6-day-old Japanese female had solitary her left wrist at birth. biopsy was first performed 16 days of age, when likely fully developed. Thereafter, gradually regressed. second 58 already in phase early regression. Finally, resected 20 months it late Our study demonstrated that undifferentiated immature histiocytic cells predominated...
Abstract A 52‐year‐old Japanese woman with the chief complaint of marked swelling her upper eyelids and a mass over bulbar conjunctiva is reported. She previously noticed frequent purpura after minimal trauma, which was resolved shortly taking some ascorbic acid. Laboratory data showed Ig‐G κ type M‐protein in serum Bence‐Jones protein urine by Immunoelectrophoresis. Systemic examination mild hepatosplenomegaly, 1st degree AV block, increase plasma cells bone marrow biopsy. Histologically,...
We describe a patient who was diagnosed with classical Hodgkin lymphoma (CHL) at 67-years-old and peripheral T-cell lymphoma, not otherwise specified (PTCL) 76-years-old, died 5 months later. Both tumors showed prominent epithelioid cell reaction admixed neoplastic cells. Reed-Sternberg cells in the swollen lymph node were positive for CD30 EBV-encoded RNA (EBER). PTCL skin tumor cytoplasmic CD3ε, CD4 EBER. A rearrangement band of receptor gene detected tumor. This case is first documented...
A 70-year-old Japanese male had de novo psoriasis after the treatment of atezolizumab, anti PD-L1 antibody agent, for lung cancer. The patient was successfully treated with conventional therapy without discontinuation agent. Our case is second atezolizumab-induced psoriasis. Atezolizumab a humanized monoclonal antiprogrammed death-ligand 1 (PD-L1) that started to be used internationally in 2016. It indicated as inoperable advanced or relapsed nonsmall cell cancer (NSCLC). Psoriasis may arise...
Despite various studies, there are serious disagreements about the cellular differentiation of papillary eccrine adenoma. In present study, 2 specimens adenoma were analyzed by immunohistochemical techniques, using a panel monoclonal antibodies against keratins, to elucidate its differentiation. Histopathologically, tumor was composed multiple tubular structures lined two or more layers epithelial cells. The luminal cells tubules flattened cuboidal. former noted in large dilated tubules....