A5012520364- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Testicular diseases and treatments
- Virus-based gene therapy research
- Sexual Differentiation and Disorders
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Immunology Research
- Vector-Borne Animal Diseases
- Cancer Genomics and Diagnostics
- Tuberculosis Research and Epidemiology
- Glioma Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Bioinformatics and Genomic Networks
- Neuroblastoma Research and Treatments
- BRCA gene mutations in cancer
Albert Schweitzer Ziekenhuis
2014-2015
Erasmus University Rotterdam
2008-2010
Meertens Institute
2009
Patients with disorders of sex development (DSD), especially those gonadal dysgenesis and hypovirilization, are at risk developing the so-called type II germ cell tumors (GCTs). Both carcinoma in situ gonadoblastoma (GB) can be precursor lesion, resulting a seminomatous or non-seminomatous invasive cancer. SRY mutations residing HMG domain found 10–15% 46,XY cases. This contains two nuclear localization signals (NLSs). In this study, we report unique case phenotypical normal woman, diagnosed...
In order to improve the efficacy of first generation adenoviral vectors for glioma treatment, we designed conditionally replicating viruses in which E1A gene is under control promoter (gfa2) glia specific intermediate filament Glial Fibrillary Acidic Protein (GFAP) and similar constructs containing additional glial enhancers.