A5081588077- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Virus-based gene therapy research
- Polyomavirus and related diseases
- thermodynamics and calorimetric analyses
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Peptidase Inhibition and Analysis
- Bioactive Compounds and Antitumor Agents
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Phonocardiography and Auscultation Techniques
- NF-κB Signaling Pathways
- Pharmacological Effects of Natural Compounds
- Machine Learning in Healthcare
- Atomic and Subatomic Physics Research
- COVID-19 diagnosis using AI
- Advanced Decision-Making Techniques
- Advanced biosensing and bioanalysis techniques
- Medicinal Plants and Bioactive Compounds
- Inflammasome and immune disorders
- Nursing Diagnosis and Documentation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
First Affiliated Hospital of Guangzhou Medical University
2015-2024
Guangzhou Medical University
2015-2024
Southern Medical University
2011-2013
Abstract Inhibitor of histone deacetylases (HDACIs) have great therapeutic value for triple negative breast cancer (TNBC) patients. Interestingly, our present study reveals that suberoyl anilide hydroxamic acid (SAHA), one the most advanced pan-HDAC inhibitor, can obviously promote in vitro motility MDA-MB-231 and BT-549 cells via induction epithelial-mesenchymal transition (EMT). SAHA treatment significantly down-regulates expression epithelial markers E-cadherin (E-Cad) while up-regulates...
Mollugin, a kind of naphthohydroquinone, is major constituent isolated from Rubia cordifolia L. and demonstrated to possess anti-inflammatory activity in recent reports. However, the effects mechanism action mollugin inflammation have not been fully defined. The present study was therefore designed investigate whether suppresses inflammatory response lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Mollugin attenuated LPS-induced expression nitric oxide (NO), inducible synthase...
Resistance to platinum-based chemotherapy becomes a major obstacle in non-small-cell lung cancer (NSCLC) treatment. Overexpression of the excision repair cross-complementing 1 (ERCC1) gene is reported negatively influence effectiveness cisplatin-based therapy for NSCLC cells. In this study, we confirm that high ERCC1 expression correlates with cisplatin resistance Importantly, histone deacetylase inhibitors (HDACis) re-sensitize ERCC1-high cells both vitro and vivo. Mechanistically, HDACi...
Standardized myrtol, an essential oil containing primarily cineole, limonene and α-pinene, has been used for treating nasosinusitis, bronchitis chronic obstructive pulmonary disease (COPD).To investigate the effects of standardized myrtol in a model acute lung injury (ALI) induced by lipopolysaccharides (LPS).Male BALB/c mice were treated with 1.5 h prior to exposure atomized LPS. Six hours after LPS challenge, was determined neutrophil recruitment, cytokine levels total protein...
Recent studies have illuminated that blocking Ca2+ influx into effector cells is an attractive therapeutic strategy for lung injury. We hypothesize T-type calcium channel may be a potential target acute injury (ALI). In this study, the pharmacological activity of mibefradil (a classical inhibitor) was assessed in mouse model lipopolysaccharide- (LPS-) induced ALI. LPS challenged mice, (20 and 40 mg/kg) dramatically decreased total cell number, as well productions TNF-α IL-6 bronchoalveolar...
Background: The clinical characteristics and risk factors of infusion reactions (IRs) are inadequately described in practice due to underreported cases. In the present study, we reported current status IRs based on an in-hospital pharmacovigilance database a tertiary care hospital. Methods: Our study conducted retrospective analysis drug-induced recorded at center between January 2015 December 2019. descriptive statistical encompassed main causative agents, manifestations, organ/system...
Background: The use of MV can easily lead to VAP especially in ICU patients. SUP, sedatives, statin and insulin have been proved prevent improve the prognosis Our aim was analyze effects sedative, statin, on patients with MV. Methods: occurrence death were explored by multivariate logistic regression Cox analyses. Results: Totally, 5277 cases who received from MIMIC IV database included. There 826 (15.7%) VAP-group 4451 (84.3%) non-VAP group there 1914 (36.3%) hospital mortalities...
In this paper, we propose an algorithm to estimate the pharmacokinetic parameters of anti-rejection drugs in lung transplantation and analyze influencing factors. The difference equations based on one-compartment model are constructed obtain each patient, including metabolic parameter absorption parameter. Afterward, use stepwise regression fit multivariate linear between factors parameters. Eight considered paper. experimental results collected data show that affected by drug sensitivity...
<title>Abstract</title> <bold>Objective:</bold> Many drugs can cause drug-induced lung injury (DLI), but its clinical features and pathogenic factors are not fully clear. The present study aims to explore the characteristics related risk of DLI provide a reference for safe application drug. <bold>Materials Methods: </bold>The patients diagnosed with in our hospital between 2014 2018 were retrospectively analyzed. was by using Japanese Respiratory Society criteria. A retrospective...
为充实抗击疫情一线的药学力量，中国药理学会药源性疾病学专业委员会和中国医院协会药事管理专业委员会委托多名药学专家讨论并撰写了本文，从个人素质、工作经历以及专业实践能力3个方面提出对支援一线药师的胜任力要求，并对准备赴一线药师的能力提升给予建议。本建议适用于为选拔赴抗击疫情一线的药师提供指引，也可为其他地区对拟赴抗疫一线药师的培训提供参考。
In order to enrich the first-line pharmaceutical force against COVID-19 epidemic, Chinese Pharmacology Society professional committee of drug-induced diseases, Pharmacy Administration Commision Hospital Association entrusted several experts discuss and write this consensus. This consensus puts forward competency requirements for front-line support pharmacists from three aspects: personal quality, work experience practice ability, gives suggestions ability improvement pharmacists. is...
Objective To explore the pharmacodynamic (PD) characteristics of propofol during anesthetic recovery period with target-controlled infusion (TCI), and to identify clinical variables related PD parameters. Materials methods 20 patients scheduled for otolaryngology surgery were enrolled. After was finished, target effect site concentration gradually decreased, blood samples measured at 7 time points differences between plasma compared. Observer's assessment alertness/sedation (OAA/S)...