A5016139255- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Herpesvirus Infections and Treatments
- Breastfeeding Practices and Influences
- Infant Nutrition and Health
- Muscle metabolism and nutrition
- RNA regulation and disease
- Sulfur Compounds in Biology
- COVID-19 Impact on Reproduction
- Hydrogen's biological and therapeutic effects
- Viral-associated cancers and disorders
- Salivary Gland Disorders and Functions
The University of Western Australia
2008-2024
Laurentian University
2021
This study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity against COVID-19 was found colostrum from infected mothers. Neutralizing associated with high levels specific IgA. Depletion IgA, but not IgG, samples completely abolished ability neutralize severe 2.
ABSTRACT Murine cytomegalovirus (MCMV) is widely used to model human (HCMV) infection. However, it known that serially passaged laboratory strains of HCMV differ significantly from recently isolated clinical HCMV. It therefore axiomatic models using MCMV may not be able fully represent the complexities system they are attempting and complex biology MCMV. To determine whether genotypic phenotypic differences also exist between wild derived MCMV, we sequenced genomes three low-passage plus...
It is becoming increasingly clear that many diseases are the result of infection from multiple genetically distinct strains a pathogen. Such multi-strain infections have capacity to alter both disease and pathogen dynamics. Infection with human cytomegalovirus (HCMV) common has been linked enhanced disease. Suggestions enhancement in infected patients due complementation supported by trans-complementation studies mice during co-infection wild type gene knockout murine CMV (MCMV)....
Hydrogen sulfide (H2 S) can be endogenously produced and belongs to the class of signaling molecules known as gasotransmitters. Cystathionine gamma-lyase (CSE)-derived H2 S is implicated in regulation cell differentiation aging process, but involvements CSE/H2 system myogenesis upon injury have not been explored. In this study, we demonstrated that CSE acts a major S-generating enzyme skeletal muscles significantly down-regulated aged mice. deficiency exacerbated age-dependent sarcopenia...
The cloning of herpesviruses as bacterial artificial chromosomes (BACs) has revolutionized the study herpesvirus biology, allowing rapid and precise manipulation viral genomes. Several clinical strains human cytomegalovirus (HCMV) have been cloned BACs; however, no low-passage murine CMV (MCMV), which provide a model mimicking these isolates, cloned. Here, G4 strain was BAC carries an m157 gene that does not ligate natural killer (NK) cell-activating receptor, Ly49H, meaning unlike...
As the largest herpesviruses, 230 kb genomes of cytomegaloviruses (CMVs) have increased our understanding host immunity and viral escape mechanisms, although many annotated genes remain as yet uncharacterised. Here we identify m15 locus murine CMV (MCMV) a modulator natural killer (NK) cell immunity. We show that, rather than discrete transcripts from m14, m16 annotated, there are five 3′-coterminal expressed over this region, all utilising consensus polyA tail at end gene. Functional...