A5075338745- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- Contact Dermatitis and Allergies
- Nail Diseases and Treatments
- Dermatological diseases and infestations
- Insect and Pesticide Research
- Digestive system and related health
- Banana Cultivation and Research
- Dermatology and Skin Diseases
- Insects and Parasite Interactions
- Immunodeficiency and Autoimmune Disorders
- Child Nutrition and Feeding Issues
- Microwave Engineering and Waveguides
- Horticultural and Viticultural Research
- Mast cells and histamine
- Neonatal Respiratory Health Research
- Autoimmune Bullous Skin Diseases
- COVID-19 Impact on Reproduction
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
The University of Western Australia
2018-2024
The Kids Research Institute Australia
2021-2024
Universidade de São Paulo
2008-2017
Universidade Estadual de Campinas (UNICAMP)
2009
Hospital de Clínicas da Unicamp
2009
This study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity against COVID-19 was found colostrum from infected mothers. Neutralizing associated with high levels specific IgA. Depletion IgA, but not IgG, samples completely abolished ability neutralize severe 2.
There is an urgent need to identify environmental risk and protective factors in early life for the prevention of allergy. Our study demonstrates presence respiratory allergen from house dust mite, Der p 1, human breast milk. 1 milk immunoreactive, present similar amounts as dietary egg antigen, can be found diverse regions world. In a mouse model asthma, oral exposure through strongly promotes sensitization rather than protect progeny we reported with antigen. These data highlight that...
In addition to being a source of nutrients for the developing newborn, human milk contains thousands bioactive compounds, which influence infant health in short-term as exemplified by its major benefits on infectious disease prevention. Many compounds also have required characteristics instruct immune development and guide long-term health. Prebiotics, probiotics, varied antimicrobial molecules all potential shape composition function establishing gut microbiota, is known be determinant...
Immunomodulatory proteins in human milk (HM) can shape infant immune development. However, strategies to modulate their levels are currently unknown. This study investigated whether maternal prebiotic supplementation alters the of immunomodulatory HM.
Oral tolerance induction in early life is a promising approach for food allergy prevention. Its success requires the identification of factors necessary its persistence.We aimed to assess mice duration prevention by breastfeeding-induced oral and whether TGF-β supplementation after weaning would prolong it.We quantified ovalbumin (OVA) OVA-specific immunoglobulin levels ELISA milk from EDEN birth cohort. As Ig was found all samples, we assessed OVA-immunized exposed OVA during lactation...
There is strong evidence from animal models that placental and/or breast milk-mediated transfer of maternal allergen-specific IgG prevents allergic immune responses in the progeny. Both human and data also point to IgA as having an important regulatory role. In contrast, little known about specific for respiratory allergens humans. Dermatophagoides pteronyssinus (Der p) indoor allergen a major cause asthma worldwide. We analysed child Der p-specific cohort 77 paired samples. found its IgG1,...
The relationship between allergen exposure and the onset of or protection from allergic diseases remains unclear. Many factors could be related to immunological responses, such as age when occurs, type allergen, timing, dose, route. In this study, we investigated whether respiratory allergens occur in pregnancy early life. particular, assessed Der p 1 Blo t 5, well specific antibodies against these allergens, detected 90 paired cord blood colostrum samples. was 58.6% 29% samples, whereas...
Impact of exposure to environmental allergens during early life on allergic sensitization and disease development is controversial. We investigated whether airborne allergen from Dermatophagoides pteronyssinus (Der p), a major cause asthma, found in human breast-milk examined its impact outcome mouse model. Der p 1 was quantified colostrum milk samples Brasil, Australia France by ELISA. Basophil degranulation assay used confirm immunogenicity p. BALB/c mice were fostered mothers exposed...
Evergreen species of temperate regions are dominant in low-nutrient soils. This feature is attributed to more efficient mechanisms nutrient economy. Nevertheless, the cashew (Anacardium occidentale- Anacardiaceae), a deciduous species, native Brazil with sandy soil, whilst annatto (Bixa orellana- Bixaceae), classified as an evergreen tropical America, grows spontaneously humid Evergreens contain robust leaves that can resist adverse conditions for longer. The physical aspects and economy...
Background: Immunomodulatory proteins in human milk (HM) can shape infant immune development. However, strategies to modulate their levels are currently unknown. This study investigated whether maternal prebiotic supplementation alters the of immunomodulatory HM. Methods: The was nested within SYMBA double-blind randomised controlled trial (ACTRN12615001075572), which is investigating effects (scGOS/lcFOS) from <21 weeks gestation during pregnancy until 6-months postnatal lactation on...
Allergies are major noncommunicable diseases associated with significant morbidity, reduced quality of life, and high healthcare costs. Despite decades research, it is still unknown if early-life exposure to indoor allergens plays a role in the development IgE-mediated allergy asthma. The objective this study contribute identification risk factors for developing allergy. We addressed whether two different sources house dust mite Der p 1 allergen during early i.e., human milk dust, have...