A5050563833- Mosquito-borne diseases and control
- Viral Infections and Vectors
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Malaria Research and Control
- HIV/AIDS Research and Interventions
- Insect symbiosis and bacterial influences
- Dengue and Mosquito Control Research
- Zoonotic diseases and public health
- Plant Virus Research Studies
- Viral Infections and Outbreaks Research
- Animal Disease Management and Epidemiology
- Global Maternal and Child Health
- Bacillus and Francisella bacterial research
- HIV, Drug Use, Sexual Risk
- Vaccine Coverage and Hesitancy
- T-cell and Retrovirus Studies
- Hepatitis C virus research
- Syphilis Diagnosis and Treatment
- HIV-related health complications and treatments
- Viral Infections and Immunology Research
- Disaster Response and Management
- Public Health Policies and Education
- COVID-19 Impact on Reproduction
- vaccines and immunoinformatics approaches
The University of Western Australia
2016-2025
Pathwest Laboratory Medicine
2016-2022
In-Q-Tel
2021
Institute of Infection and Immunity
2020
Universitas Syiah Kuala
2019
University of Hawaiʻi at Mānoa
1996-2013
National Centre for Clinical Research on Emerging Drugs
1996-2002
United States Public Health Service
1999
OLVG
1997
University of Amsterdam
1997
To provide a national incidence rate and case fatality of dengue hemorrhagic fever in Indonesia through an analysis the National Disease Surveillance database from Directorate General Prevention Control Ministry Health.Available data has indicated increasing trend over past 50 years. Incidence rates appear to be cyclic, peaking approximately every 6-8 In contrast, decreased by half each decade, since 1980. Java Island contributed highest average number cases year. recent years, Bali Borneo...
ABSTRACT Mosquitoes harbor a high diversity of RNA viruses, including many that impact human health. Despite growing effort to describe the extent and nature mosquito virome, little is known about how these viruses persist, spread, interact with both their hosts other microbes. To address this issue we performed metatranscriptomics analysis 12 Western Australian populations structured by species geographic location. Our results identified complete genomes 24 from diverse range viral families...
The Indonesian region of Aceh was the area most severely affected by earthquake and tsunami 26 December 2004. Department Health data reveal an upward trend dengue cases in since events tsunami. Despite increasing incidence region, there is limited understanding among general population Aceh. aim this study to assess knowledge, attitude, practice (KAP) regarding people Aceh, Indonesia order design intervention strategies for effective prevention program. A community-based cross-sectional...
A fatal case of Japanese encephalitis (JE) occurred in a resident the Tiwi Islands, Northern Territory Australia February 2021, preceding large JE outbreak south-eastern 2022. This study reports detection, whole genome sequencing and analysis virus responsible (designated JEV/Australia/NT_Tiwi Islands/2021).Reverse transcription quantitative PCR (RT-qPCR) testing was performed on post-mortem brain specimens using range (JEV)-specific assays. Virus isolation from attempted by inoculation...
Human immunodeficiency virus type 1 (HIV-1) resistant to the nonnucleoside reverse transcriptase inhibitor nevirapine and nucleoside analogue zidovudine was transmitted from a homosexual man his sex partner. The source patient had commenced combination therapy 2.5 years prior partner's primary HIV infection. He received both therapies for 7 months, then discontinued treatment, continuing receive monotherapy further 16 months. ceased 6 months before time of seroconversion. Analysis major...
We investigated the duration of humoral responses to dengue virus infection in individuals who recalled experiencing fever–like illnesses at time Second World War, when fever epidemics occurred throughout Pacific and Southeast Asia. In July 1943 reappeared Hawaii following an interval 31 years. Over next 12 months a total 1498 locally transmitted cases were reported, least 46 imported identified, most which among members military returning from Theatre war. Serum samples collected 2005, more...
ABSTRACT Proinflammatory cytokines secreted by memory CD8 + and CD4 T cells are thought to play a direct role in the pathogenesis of dengue virus infection increasing vascular permeability thereby inducing pathophysiologic events associated with hemorrhagic fever shock syndrome. Severe disease is frequently observed setting secondary heterologous serotypes, suggesting for cross-reactive immunopathogenesis severe disease. We used large panel well-characterized virus-specific T-cell clones...
Cerebrospinal fluid (CSF) pleocytosis may be seen in asymptomatic HIV-infected individuals. This finding complicates interpretation of CSF abnormalities when such individuals are evaluated for other central nervous system infections. The goal this study was to determine the relationship between pleocytosis, (CNS) antiretroviral penetration, adherence medication regimens, neurological symptoms and performance on neuropsychological tests. Clinically stable at any peripheral blood CD4+ T cell...
This study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity against COVID-19 was found colostrum from infected mothers. Neutralizing associated with high levels specific IgA. Depletion IgA, but not IgG, samples completely abolished ability neutralize severe 2.
Abstract COVID-19 vaccines are crucial in reducing SARS-CoV-2 transmission and severe health outcomes. Despite widespread administration, their long-term systemic effects on human metabolism remain inadequately understood. This longitudinal study aims to evaluate IgG responses, 34 cytokines, 112 lipoproteins, 21 low-molecular-weight metabolites 33 individuals receiving two four vaccine doses. Changes metabolic profiles for the first 16 days post each dose of vaccine, up 480 post-initial...
Objectives Nevirapine is a non-nucleoside reverse transcriptase inhibitor of HIV-1 which exhibits synergy in vitro with zidovudine (ZDV) and also active against ZDV-resistant HIV. We evaluated the activity safety nevirapine combination ZDV patients receiving long-term therapy. Methods conducted randomized, open-label, controlled 28-week study (200 mg daily for 2 weeks followed by 200 twice 26 weeks) continued (500–600 daily) versus alone 49 p24 antigenaemic CD4+ lymphocyte counts < 500×106/l...
During the 10-year period from 1997 through 2006, reported mean annual incidence rate of leptospirosis in state Hawaii was 3.3/100,000 with a range 22–60 infections each year. Because clinical presentation is highly variable, however, illness challenging to recognize and may be underdiagnosed. To assess whether substantially higher than figures indicate, we retrospectively studied prevalence anti-Leptospira IgM antibodies among specimens obtained over 12-month (May 2001 April 2002) patients...
Dengue virus (DENV) transmission is ubiquitous throughout the tropics. More than 70% of current global dengue disease burden borne by people who live in Asia-Pacific region. We sequenced E gene DENV isolated from travellers entering Western Australia between 2010–2012, most whom visited Indonesia, and identified a diverse array DENV1-4, including multiple co-circulating viral lineages. Most viruses were closely related to lineages known have circulated Indonesia for some time, indicating...
Severe flooding has been linked to outbreaks of leptospirosis. Two sequential extreme flood events in Western Fiji caused the largest outbreak leptospirosis recorded South Pacific, with 1,217 total suspected cases, which 314 were probable and confirmed. Most (83%) cases occurred within 6 weeks events, displaying a biphasic epidemic curve associated floods. Given temporal proximity most transmission appeared occur during or immediately after floods; therefore, prevention exposure contaminated...
Dengue virus infection is the most rapidly spreading vector-borne disease in world. Essential research on dengue transmission and its prevention requires community participation. Therefore, it crucial to understand factors that are associated with willingness of communities high prevalence areas participate research. The aim this study was explore healthy members Aceh province, Indonesia, would require phlebotomy.A community-based cross-sectional carried out nine regencies municipalities...
Mosquitoes harbor a wide diversity of microorganisms, including viruses that are human pathogens, or insect specific. We used metatranscriptomics, an unbiased high-throughput molecular approach, to describe the composition viral and other microbial communities in six medically important mosquito species from across Western Australia: Aedes vigilax, Culex annulirostris, Cx. australicus, globocoxitus, pipiens biotype molestus, quinquefasciatus. identified 42 species, 13 novel viruses, 19...
High-dose nevirapine treatment has been reported to confer sustained antiretroviral effects, despite a rapid development of resistance. The use this strategy was evaluated in 20 previously untreated human immunodeficiency virus type 1 (HIV-1) p24 antigenemic persons with CD4 cell counts between 100 and 500/mm3. Treatment consisted 400 mg nevirapine, after 2-week lead-in dose 200 mg. Rash the most frequently adverse event, occurring 25%. While declines antigen levels were observed majority,...
We evaluated the FDA-cleared InBios dengue virus (DENV) IgM capture enzyme-linked immunosorbent assay (ELISA) for qualitative detection of anti-DENV antibodies from 79 serum samples obtained virus-infected patients or suspected cases. The agreement, sensitivity, and specificity compared to gold standard in-house DENV ELISA were 94, 92, 94%, respectively. conclude that can be effectively used rapid diagnosis acute recent infection.
Arboviruses are maintained and transmitted through an alternating biological cycle in arthropods vertebrates, with largely incidental disease humans animals. As such, they provide excellent examples of One Health, as their health impact is inextricably linked to vertebrate hosts, arthropod vectors the environment. Prevention control requires a comprehensive understanding these interactions, how may be effectively safely modified. This review concentrates on human due Ross River Murray Valley...