The peroxisome proliferator–activated receptor γ (PPARγ) is highly expressed in the colon mucosa and its activation has been reported to protect against colitis. We studied involvement of PPARγ heterodimeric partner, retinoid X (RXR) intestinal inflammatory responses. PPARγ1/− RXRα1/− mice both displayed a significantly enhanced susceptibility 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis compared with their wild-type littermates. A role for RXR/PPARγ heterodimer protection...

Teichoic acids (TAs), and especially lipoteichoic (LTAs), are one of the main immunostimulatory components pathogenic Gram-positive bacteria. Their contribution to immunomodulatory properties commensal bacteria lactic acid has not yet been investigated in detail. To evaluate role TAs interaction between immune system, we analyzed antiinflammatory a mutant Lactobacillus plantarum NCIMB8826 affected TA biosynthesis pathway both vitro (mononuclear cells stimulation) vivo (murine model colitis)....

The postnatal maturation of the gut, partially modulated by bacterial colonization, ends up in establishment an efficient barrier to luminal antigens and bacteria. use broad-spectrum antibiotics pediatric practices alters gut colonization and, consequently, may impair function. To test this hypothesis, suckling Sprague-Dawley rats received a daily intragastric gavage antibiotic (Clamoxyl; amoxicillin-based commercial preparation) or saline solution from day 7 (d7) until d17 d21. Luminal...

ABSTRACT Objectives: Psychological stress during the neonatal period results in intestinal barrier dysfunction and growth alterations later life. We aimed to restore impaired function rate by a nutritional intervention. Methods: Male rat pups (n = 84) were assigned 1 of 2 rearing conditions from postnatal day (PND) PND14: S, separated 3 h/d their mothers, or H, 15 min/d handled controls. From PND15 PND35, rats received control diet similar adapted contain arachidonic docosahexaenoic acids,...

Cite this as: J. Wassenberg, S. Nutten, R. Audran, N. Barbier, V. Aubert, Moulin, A. Mercenier and F. Spertini, Clinical & Experimental Allergy, 2011 (41) 565–573. Summary Background Probiotics have been associated with prevention improvement of symptoms in atopic diseases such as dermatitis. However, few studies exist that document their efficacy for upper airways allergies allergic rhinitis. Objective To investigate the effect short‐term oral administration Lactobacillus paracasei ST11...

Introduction . Preclinical and clinical evidences for a role of oral probiotics in the management allergic diseases are emerging. Aim We aimed at testing immunomodulatory effects intranasal versus intragastric administration Lactobacillus paracasei NCC2461 mouse model airway inflammation specificity different by comparing L. to plantarum NCC1107. Methods or NCC1107 strains were administered either intragastrically (NCC2461) intranasally (NCC2461 NCC1107) OVA-sensitized mice challenged with...

A major drawback of oral immunotherapy for food allergy is the possibility severe side-effects. We assessed both safety and efficacy a low allergenic hydrolysed egg (HydE) preparation used in double-blind placebo-controlled randomized study allergic children.In pilot multicentre study, 29 patients (aged 1-5.5 years) were administered daily 6 months 9 g HydE or placebo blinded, manner. Safety was verified by challenge to assess tolerance towards at start an open (OFC, primary outcome) end....

Naïve T cells are key players in cancer immunosurveillance, even though their function declines during tumor progression. Thus, interventions capable of sustaining the quality and naïve needed to improve immunoprevention.In this context, we studied capacity Urolithin-A (UroA), a potent mitophagy inducer, enhance cell-mediated immunosurveillance.We discovered that UroA improved immune response by activating transcription factor FOXO1 CD8+ cell. Sustained activation promoted expression...

The incidence of food hypersensitivity and allergies is on the rise new treatment approaches are needed. We investigated whether N. sativa, one its components, thymoquinone, or synthetic opioid receptor (OR)-agonists can alleviate allergy. Hence, ovalbumin (OVA) -sensitized BALB/c-mice were pre-treated either with a hexanic sativa seed extract, kappa- (U50'4889) mu-OR-agonists (DAMGO) subsequently challenged intra-gastrically OVA. All 4 treatments significantly decreased clinical scores...

Background The hygiene hypothesis implies that microbial agents including probiotic bacteria may modulate foetal/neonatal immune programming and hence offer effective strategies for primary allergy prevention; however their mechanisms of action are poorly understood. We investigated whether oral administration Lactobacillus paracasei NCC 2461 to mothers during gestation/lactation can protect against airway inflammation in offspring a mouse model birch pollen allergy, examined the involved....

Polyphenols are naturally derived bioactive compounds with numerous reported health benefits. We have previously on the beneficial effect of a polyphenol-enriched apple extract in murine model food allergy. The objectives present study were to elucidate class polyphenols that exhibit anti-allergic and assess whether protective matches vivo bioavailable metabolite concentrations. Female BALB/c mice sensitised ovalbumin (OVA) following protocol well-established They fed diets containing...

There is promising but conflicting evidence to recommend the addition of probiotics foods for prevention and treatment allergy. Based on previous studies with fermented milk containing Lactobacillus paracasei NCC2461, we aimed compare effect a powder form latter probiotic blend acidophilus ATCC SD5221 Bifidobacterium lactis SD5219 in patients allergic rhinitis.A double-blind, randomized, cross-over study, involving 31 adults rhinitis grass pollen, was performed outside pollen season...

<b><i>Background/Aims:</i></b> Atopic dermatitis (AD) is a common disease in infancy, for which topical steroids are the first-line therapy but have side effects. Innovative approaches needed to reduce burden of AD and corticosteroid usage infants. <b><i>Methods:</i></b> The once-daily consumption heat-treated probiotic <i>Lactobacillus paracasei</i> GM-080 or placebo 16 weeks as supplementary approach treatment with fluticasone...

Egg allergy is one of the most common food allergies in children. The standard therapy for egg strict avoidance. Yet, there considerable clinical and scientific interest primary or secondary prevention. A major drawback oral tolerance (OT) induction protocols, however, possibility severe side effects; thus, we have formulated a hypoallergenic product demonstrate its vivo capacity to modulate immune system current study.Hydrolyzed (HE) was produced using combination moderate heat treatment...

Eosinophilic esophagitis (EoE) is a severe inflammatory disease of the esophagus which characterized histologically by an eosinophilic infiltration into esophageal tissue. The efficacy probiotics in context atopic diseases has been well investigated but, to date, there no study evaluated probiotic effects on EoE inflammation. This sought identify improves inflammation experimental EoE.Two candidate probiotics, Lactococcus lactis NCC 2287 and Bifidobacterium 2818, were tested murine model...

ABSTRACT A single intradermal administration of recombinant interleukin-7 (IL-7) has been shown to aggravate the course murine schistosomiasis, favor development Th2-associated antibodies specific for parasite, and alter migration kinetics and/or migratory route parasite within its vertebrate host. Here we show that after infection IL-7-deficient mice with Schistosoma mansoni , predominant parasite-specific humoral response follows a Th1 pattern, is greatly impaired. In mice, increased...

Oral tolerance induction in early life is a promising approach for food allergy prevention. Its success requires the identification of factors necessary its persistence.We aimed to assess mice duration prevention by breastfeeding-induced oral and whether TGF-β supplementation after weaning would prolong it.We quantified ovalbumin (OVA) OVA-specific immunoglobulin levels ELISA milk from EDEN birth cohort. As Ig was found all samples, we assessed OVA-immunized exposed OVA during lactation...