A5021310578- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Neuroblastoma Research and Treatments
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Advanced Radiotherapy Techniques
- Curcumin's Biomedical Applications
- Cancer therapeutics and mechanisms
- Radiation Therapy and Dosimetry
- Tissue Engineering and Regenerative Medicine
- Nanoplatforms for cancer theranostics
- Cancer-related Molecular Pathways
- Chemical Reactions and Isotopes
- Cancer, Lipids, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Bioactive Compounds and Antitumor Agents
- Ion channel regulation and function
- Brain Metastases and Treatment
- Pituitary Gland Disorders and Treatments
- Wnt/β-catenin signaling in development and cancer
Université de Strasbourg
2025
Institut de Cancérologie Strasbourg
2023-2025
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2025
American University of Beirut Medical Center
2019-2024
American University of Beirut
2020-2023
Mount Sinai Medical Center
2021
Lebanese University
2020
Orientation and steric hindrance decrease the efficiency for an antibody to attach its specific receptor. Giving flexibility a dendronized peptide through small PEG fragment increases peptides affinity cellular receptors.
Ionizing radiation can influence the antitumor immune response, either activating or suppressing system depending on tumor type and radiotherapy modality. While photon (RT) combined with immunotherapy (IT) is widely studied in clinical trials, proton (PT) IT has not been thoroughly investigated preclinical studies despite its radiobiological advantages. This study aims to explore effects of a hypofractionated PT scheme compared RT efficacy anti-PD-L1 immunotherapy. Balb/c mice bearing...
Structural modifications of the antibacterial drug nitrofurantoin were envisioned, employing repurposing and biology-oriented synthesis, to serve as possible anticancer agents. Eleven compounds showed superior safety in non-cancerous human cells. Their antitumor efficacy was assessed on colorectal, breast, cervical, liver cancer Three induced oxidative DNA damage cells with subsequent cellular apoptosis. They also upregulated expression Bax while downregulated that Bcl-2 along activating...
Background: Bladder cancer is the fourth most commonly diagnosed among males worldwide. Current treatment strategies established for bladder mainly consist of cystectomy yet advances in radiation therapy have pointed to value organ-preserving preserving patients' quality life. Aim: To study and compare radiosensitivity two-dimension (2D) physiologically-relevant three-dimension (3D) vitro culture 3 human cell lines, RT4, T24 UM-UC-3. Materials methods: Clonogenic assay was performed assess...
Children with cancer previously treated radiotherapy face the likelihood of side effects that can be debilitating or fatal. This study aimed to assess long-term effect medulloblastoma on DNA double-strand break (DSB) repair capability primary fibroblasts derived from lung biopsies irradiated young sheep. included three control and five The sheep had received spinal at a total dose 28 Gy, which is equivalent pediatric treatment. Lung were taken 4 years post-irradiation high-dose (HD, >18 Gy)...
Chemo-radiotherapy is one of the promising approaches to treat bladder cancer, but its effectiveness limited sensitive patients. Polyphenol curcumin has shown anticancer and radiosensitizing potentials, mechanism not fully understood. Here, In Vitro response UM-UC5 UM-UC6 cell lines radiation treatments was evaluated. The effect on DNA double-strand breaks repair system after treatment with ionizing (2 Gy) determined by immunofluorescence. Cell viability, proliferation, survival were...
While radical cystectomy remains the primary treatment of choice for bladder cancer, increased evidence supports use bladder-preservation strategies based on adjuvant radiotherapy. This highlights need a better understanding cancer radiosensitivity to different types deliveries. The purpose this study is analyze effect time, dose and fractionation number sizes grown three-dimensional (3D) spheres, assess capacity linear-quadratic model in describing response cells cultured 3D. 3D...
Abstract Neuroblastoma is an embryonic tumor that represents the most common extracranial solid in children. Resistance to therapy attributed, part, persistence of a subpopulation slowly dividing cancer stem cells (CSCs) within those tumors. Glycogen synthase kinase (GSK)-3β active proline-directed serine/threonine kinase, well-known be involved different signaling pathways entangled pathophysiology neuroblastoma. This study aims assess potency irreversible GSK-3β inhibitor drug, Tideglusib...