A5087771719- PARP inhibition in cancer therapy
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Radiation Therapy and Dosimetry
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- DNA Repair Mechanisms
- Autophagy in Disease and Therapy
- Cancer Treatment and Pharmacology
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Caveolin-1 and cellular processes
- Anatomy and Medical Technology
- Cellular Mechanics and Interactions
- Brain Metastases and Treatment
- Cell death mechanisms and regulation
- Advanced Electron Microscopy Techniques and Applications
Institut de Cancérologie Strasbourg
2020-2025
Université de Strasbourg
2013-2025
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2023-2024
UniCancer Group
2021
Universidad Católica Cecilio Acosta
2021
Centre National de la Recherche Scientifique
2020
Levi Strauss (United States)
2015-2019
Abstract Radiotherapy delivered using photons induces an immune response that leads to modulation of the tumor microenvironment. Clinical studies are ongoing evaluate checkpoint inhibitors in association with photon radiotherapy. At present, there is no publication on radio-induced after proton therapy. Balb/c mice bearing subcutaneous CT26 colon tumors were irradiated by a single fraction 16.4 Gy beam extracted from TR24 cyclotron. RNA sequencing analysis was assessed at 3 days...
Ionizing radiation can influence the antitumor immune response, either activating or suppressing system depending on tumor type and radiotherapy modality. While photon (RT) combined with immunotherapy (IT) is widely studied in clinical trials, proton (PT) IT has not been thoroughly investigated preclinical studies despite its radiobiological advantages. This study aims to explore effects of a hypofractionated PT scheme compared RT efficacy anti-PD-L1 immunotherapy. Balb/c mice bearing...
Over the past few years, studies have focused on development of targeted radiosensitizers such as poly(ADP-ribose) polymerase inhibitors. We performed an in vivo study and a whole-transcriptome analysis to determine whether PARP inhibition enhanced gemcitabine-based chemoradiosensitization pancreatic cancer xenografts, combined with either proton or photon irradiation. NMRI mice bearing MIA PaCa-2 xenografts were treated olaparib and/or gemcitabine irradiated 10 Gy proton. First, significant...
Pancreatic ductal adenocarcinoma is a devastating disease with 5-year overall survival of 9% for all stages. Gemcitabine-based chemoradiotherapy locally advanced pancreatic cancer highly toxic. We conducted an in vitro study to determine whether poly(ADP-ribose) polymerase-1 inhibition radiosensitized gemcitabine-based chemotherapy. Human cell lines, MIA PaCa-2, AsPC-1, BxPC-3 and PANC-1 were treated gemcitabine (10 nM) and/or olaparib (1 µM). Low-LET gamma single dose 2, 5 10 Gy radiations...
The EGFR-targeting antibody cetuximab (CTX) combined with radiotherapy is the only targeted therapy that has been proven effective for treatment of locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Recurrence arises in 50% patients HNSCC years following treatment. In clinicopathological practice, it difficult to assign classes risk because no reliable biomarkers are available predict outcome HPV-unrelated HNSCC. present study, we investigated role Caveolin-1 (Cav1)...
Radiotherapy, the most frequent treatment of oral squamous cell carcinomas (OSCC) besides surgery is employed to kill tumor cells but, radiotherapy may also promote relapse where immune-suppressive microenvironment (TME) could be instrumental. We established a novel syngeneic grafting model from carcinogen-induced tongue tumor, OSCC13, address impact on OSCC. This revealed similarities with human OSCC, recapitulating mutations found in smoking associated tumors, abundant infiltrating...
Radiation therapy and platinum-based chemotherapy are common treatments for lung cancer patients. Several factors considered the low overall survival rate of cancer, such as patient's physical state complex heterogeneity tumor, which leads to resistance treatment. Consequently, precision medicines needed patients improve their quality life. Until now, no patient-derived tumoroid model has been reported predict efficiency radiation in non-small-cell cancer. Using our model, we report that...
Background: Pediatric high-grade gliomas (pHGGs) are the leading cause of mortality in pediatric neuro-oncology, displaying frequent resistance to standard therapies. Profiling DNA repair and cell cycle gene expression has recently been proposed as a strategy classify adult glioblastomas. To improve our understanding damage response pathways that operate pHGGs vulnerabilities these might expose, we sought identify characterize specific cell-cycle signature pHGGs. Methods: Transcriptomic...
Abstract Improving the tumor reoxygenation to sensitize radiation therapy is a cornerstone in oncology. Here, pre‐clinical development of clinically transferable liposomal formulation encapsulating trans sodium crocetinate (NP TSC) reported improve oxygen diffusion through environment. Early pharmacokinetic analysis clinical trial this molecule performed on 37 patients orient define optimal fixed dosage use triple‐negative breast cancer model validate therapeutic combination and NP TSC....