NFDI4DS | UHH-SEMS - Publication Details

Stefania Durando

ORCID: 0000-0002-9986-919X

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A5071393480

Research Areas

Gastric Cancer Management and Outcomes
Lung Cancer Treatments and Mutations
Radiomics and Machine Learning in Medical Imaging
Cancer Genomics and Diagnostics
RNA modifications and cancer
Cancer Research and Treatments
Helicobacter pylori-related gastroenterology studies
Molecular Biology Techniques and Applications
Genetic factors in colorectal cancer
HER2/EGFR in Cancer Research
Cancer Cells and Metastasis
Colorectal Cancer Treatments and Studies
MicroRNA in disease regulation
Digestive system and related health
Monoclonal and Polyclonal Antibodies Research
Cytokine Signaling Pathways and Interactions
Viral-associated cancers and disorders
Nanoplatforms for cancer theranostics
Cancer, Stress, Anesthesia, and Immune Response
Lymphoma Diagnosis and Treatment
Immune Cell Function and Interaction

Candiolo Cancer Institute
2017-2023

Istituti di Ricovero e Cura a Carattere Scientifico
2017-2018

A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

OPENALEX - Publications

Simona Corso Claudio Isella Sara E. Bellomo Maria Apicella Stefania Durando and 45 more

Abstract Gastric cancer is the world's third leading cause of mortality. In spite significant therapeutic improvements, clinical outcome for patients with advanced gastric poor; thus, identification and validation novel targets extremely important from a point view. We generated wide, multilevel platform models, comprising 100 patient-derived xenografts (PDX), primary cell lines, organoids. Samples were classified according to their histology, microsatellite stability, Epstein–Barr virus...

10.1158/0008-5472.can-19-1166 article EN Cancer Research 2019-10-04

Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts

OPENALEX - Publications

Simona Corso Marilisa Cargnelutti Stefania Durando Silvia Menegon Maria Apicella and 28 more

Patient-Derived Xenografts (PDXs), entailing implantation of cancer specimens in immunocompromised mice, are emerging as a valuable translational model that could help validate biologically relevant targets and assist the clinical development novel therapeutic strategies for gastric cancer. More than 30% PDXs generated from carcinoma samples developed human B-cell lymphomas instead These were monoclonal, Epstein Barr Virus (EBV) positive, originated tumorigenic cell cultures displayed...

10.1016/j.neo.2018.02.003 article EN cc-by-nc-nd Neoplasia 2018-03-23

Personalized therapeutic strategies in HER2-driven gastric cancer

OPENALEX - Publications

Stefano Ughetto Cristina Migliore Filippo Pietrantonio Maria Apicella Annalisa Petrelli and 38 more

10.1007/s10120-021-01165-w article EN Gastric Cancer 2021-03-23

Optimized EGFR Blockade Strategies in EGFR Addicted Gastroesophageal Adenocarcinomas

OPENALEX - Publications

Simona Corso Filippo Pietrantonio Maria Apicella Cristina Migliore Daniela Conticelli and 37 more

Gastric and gastroesophageal adenocarcinomas represent the third leading cause of cancer mortality worldwide. Despite significant therapeutic improvement, outcome patients with advanced adenocarcinoma is poor. Randomized clinical trials failed to show a survival benefit in molecularly unselected treated anti-EGFR agents.

10.1158/1078-0432.ccr-20-0121 article EN Clinical Cancer Research 2021-02-04

Supplementary Figure S2 from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

OPENALEX - Publications

Simona Corso Claudio Isella Sara E. Bellomo Maria Apicella Stefania Durando and 45 more

Organoids contain few or no stroma component and when reinjected in mice originated tumors resembling the corresponding PDXs.

10.1158/0008-5472.22422273 preprint EN cc-by 2023-03-31

Supplementary Figure S3 from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

OPENALEX - Publications

Simona Corso Claudio Isella Sara E. Bellomo Maria Apicella Stefania Durando and 45 more

ROC curves of Lee MSI signature predicting genetic status in PDXs and TCGA samples cohorts.

10.1158/0008-5472.22422270 preprint EN cc-by 2023-03-31

Supplementary Figure S3 from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

OPENALEX - Publications

Simona Corso Claudio Isella Sara E. Bellomo Maria Apicella Stefania Durando and 45 more

ROC curves of Lee MSI signature predicting genetic status in PDXs and TCGA samples cohorts.

10.1158/0008-5472.22422270.v1 preprint EN cc-by 2023-03-31

Supplementary Methods from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

OPENALEX - Publications

Simona Corso Claudio Isella Sara E. Bellomo Maria Apicella Stefania Durando and 45 more

Supplementary Methods

10.1158/0008-5472.22422267.v1 preprint EN cc-by 2023-03-31

Supplementary Figure S2 from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

OPENALEX - Publications

Simona Corso Claudio Isella Sara E. Bellomo Maria Apicella Stefania Durando and 45 more

Organoids contain few or no stroma component and when reinjected in mice originated tumors resembling the corresponding PDXs.

10.1158/0008-5472.22422273.v1 preprint EN cc-by 2023-03-31

Supplementary Methods from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

OPENALEX - Publications

Simona Corso Claudio Isella Sara E. Bellomo Maria Apicella Stefania Durando and 45 more

Supplementary Methods

10.1158/0008-5472.22422267 preprint EN cc-by 2023-03-31

Supplementary Figure S1 from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

OPENALEX - Publications

Simona Corso Claudio Isella Sara E. Bellomo Maria Apicella Stefania Durando and 45 more

Microsatellite instability (MSI) phenotype in primary gastric tumours and their corresponding PDX/ organoid

10.1158/0008-5472.22422276.v1 preprint EN cc-by 2023-03-31

Data from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

OPENALEX - Publications

Simona Corso Claudio Isella Sara E. Bellomo Maria Apicella Stefania Durando and 45 more

<div>AbstractGastric cancer is the world's third leading cause of mortality. In spite significant therapeutic improvements, clinical outcome for patients with advanced gastric poor; thus, identification and validation novel targets extremely important from a point view. We generated wide, multilevel platform models, comprising 100 patient-derived xenografts (PDX), primary cell lines, organoids. Samples were classified according to their histology, microsatellite stability,...

10.1158/0008-5472.c.6511170 preprint EN 2023-03-31

Data from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

OPENALEX - Publications

Simona Corso Claudio Isella Sara E. Bellomo Maria Apicella Stefania Durando and 45 more

10.1158/0008-5472.c.6511170.v1 preprint EN 2023-03-31

Supplementary Figure S1 from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

OPENALEX - Publications

Simona Corso Claudio Isella Sara E. Bellomo Maria Apicella Stefania Durando and 45 more

Microsatellite instability (MSI) phenotype in primary gastric tumours and their corresponding PDX/ organoid

10.1158/0008-5472.22422276 preprint EN cc-by 2023-03-31

Table S3 from Optimized EGFR Blockade Strategies in EGFR Addicted Gastroesophageal Adenocarcinomas

OPENALEX - Publications

Simona Corso Filippo Pietrantonio Maria Apicella Cristina Migliore Daniela Conticelli and 37 more

Supplementary Table 3

10.1158/1078-0432.22481690 preprint EN cc-by 2023-03-31

Figure S4 from Optimized EGFR Blockade Strategies in EGFR Addicted Gastroesophageal Adenocarcinomas

OPENALEX - Publications

Simona Corso Filippo Pietrantonio Maria Apicella Cristina Migliore Daniela Conticelli and 37 more

Supplementary Figure 4_Revised

10.1158/1078-0432.22481708 preprint EN cc-by 2023-03-31

Figure S1 from Optimized EGFR Blockade Strategies in EGFR Addicted Gastroesophageal Adenocarcinomas

OPENALEX - Publications

Simona Corso Filippo Pietrantonio Maria Apicella Cristina Migliore Daniela Conticelli and 37 more

Supplementary Figure 1

10.1158/1078-0432.22481717 preprint EN cc-by 2023-03-31

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