A5079767358- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Enhanced Recovery After Surgery
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Helicobacter pylori-related gastroenterology studies
- Nutrition and Health in Aging
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Molecular Biology Techniques and Applications
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- Bariatric Surgery and Outcomes
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Hospital Admissions and Outcomes
- Lung Cancer Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Digestive system and related health
Azienda Ospedaliera Universitaria Integrata Verona
2020-2024
University of Verona
2018-2023
Provincia Autonoma di Trento
2020-2022
Hospital Universitario Fundación Jiménez Díaz
2021
Royal Marsden Hospital
2017-2019
Abstract Gastric cancer is the world's third leading cause of mortality. In spite significant therapeutic improvements, clinical outcome for patients with advanced gastric poor; thus, identification and validation novel targets extremely important from a point view. We generated wide, multilevel platform models, comprising 100 patient-derived xenografts (PDX), primary cell lines, organoids. Samples were classified according to their histology, microsatellite stability, Epstein–Barr virus...
Data on ERAS for gastrectomy are scarce, and the majority of studies come from Eastern countries. Patients in West older suffer more advanced tumors that impair their clinical condition often require neoadjuvant treatment. This retrospective study assessed feasibility safety an Enhanced Recovery After Surgery (ERAS) protocol a Western center.We conducted single-center 351 patients operated gastric cancer: 103, January 2015 to December 2016, followed standard pathway, while 248, 2017 2019,...
The aim of this study was to assess the ability Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) provide functional information useful in predicting pathological response an intensive neoadjuvant chemo-radiotherapy (nCRT) protocol for both esophageal squamous cell carcinoma (SCC) and adenocarcinoma (ADC) patients.Esophageal (EC) patients, treated our Center between 2014 2018, were retrospectively reviewed. nCRT schedule consisted induction phase weekly...
Docetaxel associated with oxaliplatin and 5-fluorouracil (FLOT) has been reported as the best perioperative treatment for gastric cancer. However, there is still some debate about most appropriate number timing of chemotherapy cycles. In this randomized multicenter phase II study, patients resectable cancer were staged through laparoscopy peritoneal lavage cytology, randomly assigned (1:1) to either four cycles neoadjuvant (arm A) or two preoperative + postoperative docetaxel, oxaliplatin,...
Background: Although the Japan Clinical Oncology Group (JCOG) 9501 trial did not find that prophylactic D3 lymphadenectomy led to any survival advantage over D2 lymphadenectomy, it prognosis of subserosal and N0 gastric cancer patients improved. The aim this retrospective observational study was compare after or in different patient subgroups. Methods: considered all who underwent at a high-volume center Verona (Italy) between 1992 2011. After excluding with Bormann IV neuroendocrine tumors,...
Background: A phase II intensive neoadjuvant chemo-radiotherapy (nCRT) protocol for esophageal cancer (EC) was previously tested at our Center with promising results. We here present an observational study to evaluate the efficacy of also in “real life” patients. Methods: retrospectively reviewed 122 ECs (45.1% squamous cell (SCC) and 54.9% adenocarcinoma (ADC)) treated induction docetaxel, cisplatin, 5-fluorouracil (TCF), followed by concomitant TCF radiotherapy (50–50.4 Gy/25–28...
Abstract Background Prophylactic use of abdominal drain in gastrectomy has been questioned the last 15 years, and a 2015 Cochrane meta-analysis on four RCTs concluded that there was no convincing evidence to routine placement gastrectomy. Nevertheless, authors evidenced moderate/low quality included studies highlighted how 3 out 4 came from Eastern countries. After 2015, only retrospective have published, all with inconsistent results. Methods ADiGe (Abdominal Drain Gastrectomy) Trial is...
Abstract Evidence against the use of prophylactic drain after gastrectomy are increasing and ERAS guidelines suggest benefit avoidance. Nevertheless, it is unclear whether this practice still widespread. We conducted a survey among Italian surgeons through Gastric Cancer Research Group Polispecialistic Society Young Surgeons, aiming to understand current drain. A 28-item questionnaire-based was developed analyze individual opinion about gastrectomy. Groups based on age, experience unit...
Abstract The treatment of leak after esophageal and gastric surgery is a major challenge. Over the last few years, endoscopic vacuum therapy (E-VAC) has gained popularity in management this life-threatening complication. We reported our initial experience on E-VAC as rescue refractory anastomotic perforation gastro-esophageal surgery. From September 2017 to December 2019, total 8 therapies were placed secondary 7 patients. Six for (3 cervical, 1 thoracic, 2 abdominal) conduit. In 6 cases,...
Introduction: While enhanced recovery after surgery (ERAS) protocol demonstrated to improve outcomes gastrectomy, some papers evidenced a detrimental effect on postoperative morbidity related the “weekday effect.” We aimed understand whether day of gastrectomy could affect and compliance with ERAS items. Methods: included all patients that underwent for cancer between January 2017 September 2021. Cohort was divided considering surgery: Early group (Monday–Wednesday) Late (Thursday–Friday)....
Abstract The optimal treatment for esophageal cancer in elderly patients is still debated and data on postoperative results are limited. This retrospective international study aims to clarify the impact of age clinical oncological outcomes after esophagectomy. All that underwent esophagectomy between 2007 2016 at two European high-volume Centers have been included study. Patients were divided into three groups according their age: young-age group (YAG) (18–69), middle-age (70–74) old-age...