A5061708924- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Gastroesophageal reflux and treatments
- RNA modifications and cancer
- Dysphagia Assessment and Management
- Molecular Biology Techniques and Applications
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Eosinophilic Esophagitis
- Lung Cancer Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Digestive system and related health
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Bariatric Surgery and Outcomes
- Intestinal Malrotation and Obstruction Disorders
- Pancreatitis Pathology and Treatment
Azienda Ospedaliera Universitaria Pisana
2013-2024
Regione Toscana
2011-2019
Ospedale Cisanello
2015-2019
University of Pisa
2013-2019
Azienda Socio Sanitaria Territoriale di Bergamo Ovest
2018
Azienda Ospedaliera Treviglio
2018
University of Perugia
2016
Christie's
2016
Creative Commons
2016
Ospedale Santa Chiara
2011
Abstract Gastric cancer is the world's third leading cause of mortality. In spite significant therapeutic improvements, clinical outcome for patients with advanced gastric poor; thus, identification and validation novel targets extremely important from a point view. We generated wide, multilevel platform models, comprising 100 patient-derived xenografts (PDX), primary cell lines, organoids. Samples were classified according to their histology, microsatellite stability, Epstein–Barr virus...
BACKGROUNDMediastinal leakage (ML) is one of the most feared complications esophagectomy.A standard strategy for its diagnosis and treatment has been
Patient-Derived Xenografts (PDXs), entailing implantation of cancer specimens in immunocompromised mice, are emerging as a valuable translational model that could help validate biologically relevant targets and assist the clinical development novel therapeutic strategies for gastric cancer. More than 30% PDXs generated from carcinoma samples developed human B-cell lymphomas instead These were monoclonal, Epstein Barr Virus (EBV) positive, originated tumorigenic cell cultures displayed...
Abstract Coronavirus Disease-19 (COVID-19) outbreak has significantly burdened healthcare systems worldwide, leading to reorganization of services and reallocation resources. The Italian Society for Study Esophageal Diseases (SISME) conducted a national survey evaluate changes in esophageal cancer management region severely struck by COVID-19 pandemic. A web-based questionnaire (26 items) was sent 12 SISME units. Short-term outcomes resections performed during the lockdown were compared with...
To investigate the prognostic value of tumor metabolism measurements on serial 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography and computed scans in patients with locally advanced esophageal cancer undergoing neoadjuvant chemoradiotherapy. Forty-five (63 ± 7 years, 6 female) treated concomitant chemoradiotherapy before surgery were followed up for 24 18 months (range 4–71). Positron obtained within 1 week start (PET1) month after completion treatment (PET2). Total body metabolic...
Abstract Background The effectiveness of bariatric surgery for weight loss in morbidly obese patients has been well established and it's becoming more common as many surgeons are trained to perform them safely, even older patients. Obesity is associated with reflux hormonal imbalances that increase the risk Barrett's esophagus, esophageal adenocarcinoma gastric cancer. Bariatric procedures alter anatomy, vascularization lymphatic drainage render subsequent upper gastrointestinal malignancies...
Abstract Background Epiphrenic esophageal diverticula are rare and often associated with motor disorders. Surgery is reserved for larger symptoms that significantly impair quality of life. When possible, a transhiatal approach can reduce pulmonary complications by preserving pleural integrity; more proximal diverticular openings require combined transthoracic abdominal to achieve complete excision. Robotic surgery assists in precise dissection preservation delicate mediastinal structures....
Abstract Aim This paper is a case report about patient with esophageal adenocarcinoma that occurred many years after laparoscopic sleeve gastrectomy (LSG), highlighting the technical difficulties an esophagectomy bariatric surgery entails. Background and methods Esophagectomy for cancer complex operation than can be associated significance morbidity mortality. Options include either partial intrathoracic (Ivor-Lewis resection) or total neck anastomosis (three field technique described by...
<p>Microsatellite instability (MSI) phenotype in primary gastric tumours and their corresponding PDX/ organoid</p>
<div>Abstract<p>Gastric cancer is the world's third leading cause of mortality. In spite significant therapeutic improvements, clinical outcome for patients with advanced gastric poor; thus, identification and validation novel targets extremely important from a point view. We generated wide, multilevel platform models, comprising 100 patient-derived xenografts (PDX), primary cell lines, organoids. Samples were classified according to their histology, microsatellite stability,...
<div>Abstract<p>Gastric cancer is the world's third leading cause of mortality. In spite significant therapeutic improvements, clinical outcome for patients with advanced gastric poor; thus, identification and validation novel targets extremely important from a point view. We generated wide, multilevel platform models, comprising 100 patient-derived xenografts (PDX), primary cell lines, organoids. Samples were classified according to their histology, microsatellite stability,...
<p>Microsatellite instability (MSI) phenotype in primary gastric tumours and their corresponding PDX/ organoid</p>