A5009353280- Cervical Cancer and HPV Research
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Microbial infections and disease research
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Molecular Biology Techniques and Applications
- Veterinary Oncology Research
- Aquaculture disease management and microbiota
- Congenital Anomalies and Fetal Surgery
- Bacteriophages and microbial interactions
- Antimicrobial Peptides and Activities
- Parasitic infections in humans and animals
- Vector-Borne Animal Diseases
- Toxoplasma gondii Research Studies
- Toxin Mechanisms and Immunotoxins
- Streptococcal Infections and Treatments
- Amoebic Infections and Treatments
- Hepatitis B Virus Studies
- Plant Virus Research Studies
- Vector-borne infectious diseases
- Rabies epidemiology and control
- Viral Infections and Vectors
- Immune Response and Inflammation
- Pneumocystis jirovecii pneumonia detection and treatment
The Pirbright Institute
2020-2024
University of Sassari
2013-2022
Lumpy skin disease virus (LSDV) is a poxvirus that causes systemic in cattle, resulting substantial economic loss to affected communities. LSDV rapidly emerging pathogen of growing global concern recently spread from Africa and the Middle East into Europe Asia, impacting cattle population these regions. An increase research efforts required address key knowledge gaps, however this hampered by lack suitable cell lines on which propagate study virus. In work we describe replication Madin-Darby...
Neutrophil granulocytes are paramount to innate responses as major effectors of acute inflammation. Among the various strategies enacted by neutrophils eliminate microbes NETosis is a novel distinct antimicrobial activity in which an interlacement chromatin fibres rich granule-derived peptides and enzymes extruded (NETs, extracellular traps ). NETs contribute pathogenesis chronic inflammatory disorders. The interactions mycoplasmas immune cells, particular neutrophil granulocytes, poorly...
Abstract Mycoplasma lipoproteins play a relevant role in pathogenicity and directly interact with the host immune system. Among human mycoplasmas, hominis is described as commensal bacterium that can be associated number of genital extragenital conditions. Mechanisms M. are still largely obscure, only limited proteins have been virulence. The current study focused on investigating MHO_0730 virulence factor demonstrated surface lipoprotein, potentially expressed vivo during natural infection,...
In this study the enzymatic activity of Mycoplasma agalactiae MAG_5040, a magnesium-dependent nuclease homologue to staphylococcal SNase was characterized and its antigenicity during natural infections established. A UGA corrected version lacking region encoding signal peptide, expressed in Escherichia coli as GST fusion protein. Recombinant GST-MAG_5040 exhibits similar typical sugar-nonspecific endo- exonucleases, with DNA preferred substrate optimal presence 20 mM MgCl2 at temperatures...
Lumpy skin disease virus (LSDV) is a member of the capripoxvirus (CPPV) genus Poxviridae family. LSDV rapidly emerging, high-consequence pathogen cattle, recently spreading from Africa and Middle East into Europe Asia. We have sequenced whole genome historical isolates Pirbright Institute archive, field recent outbreaks in Sri Lanka, Mongolia, Nigeria Ethiopia. These sequences were compared to published genomes classified different subgroups. Two subgroups contained vaccine or vaccine-like...
Sheeppox is a transboundary disease of small ruminants caused by infection with the capripoxvirus sheeppox virus. found in Africa, Middle East and Asia characterized fever, multifocal cutaneous raised lesions death. Vaccination live attenuated (CPPV) strains an effective widely used strategy to contol outbreaks; however, there are few reports post-vaccination field surveillance studies. This study commercially available enzyme-linked immunosorbent assay (ELISA) examine quantitative temporal...
Feline viral plaques are uncommon skin lesions clinically characterized by multiple, often pigmented, and slightly raised lesions. Numerous reports suggest that papillomaviruses (PVs) involved in their development. Immunosuppressed immunocompetent cats both affected, the biological behavior is variable, regression possible but rarely documented. Here we report a case of FIV-positive cat with fragility syndrome regressing multiple which contemporary presence two PV types (FcaPV2 FcaPV3) was...
Abstract Cutaneous squamous cell carcinoma (cSCC) is a malignant lesion characterized by proliferation and transformation of keratinocytes in the epidermis infiltrating derma. cSCC reported domestic wild animal species, worldwide. The occurrence development rely on synergic multifactorial conditions, most importantly sunlight exposure Papillomavirus (PV) infection. In sheep, such lesions represents threat both to welfare milk production. Ovis aries papillomavirus 3 (OaPV3) main viral...
Streptococcus suis serotype 2(SS2) is one of the most important pathogens in porcine industry and an zoonotic agent. The absence suitable vaccine or virulence markers makes SS2 infections more difficult to control. An immunoproteomics approach used for identifying antigenic proteins recognized enolase, which may represent strain-specific potential protective antigens. This study aims clone, express enolase gene from use western blotting evaluate antigenicity. Enolase strain was amplified...