A5090326176- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Spinal Cord Injury Research
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- interferon and immune responses
- Advanced Sensor and Energy Harvesting Materials
- Plant Toxicity and Pharmacological Properties
- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Tendon Structure and Treatment
- Bone Tissue Engineering Materials
- Pain Mechanisms and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related gene regulation
- Acupuncture Treatment Research Studies
- Graphene and Nanomaterials Applications
- Inflammasome and immune disorders
- Peroxisome Proliferator-Activated Receptors
- Cancer Immunotherapy and Biomarkers
- Bone and Joint Diseases
- Immune Cell Function and Interaction
- Dermatological and Skeletal Disorders
Union Hospital
2021-2025
Huazhong University of Science and Technology
2021-2025
Union Hospital
2022
Nanchang University
2020
Abstract Background The intervertebral disc (IVD) degeneration is the leading cause of low back pain, which accounts for a main disability. N 6‐methyladenosine (m6A) most abundant internal modification in eukaryotic messenger RNAs and involved various diseases cellular processes by modulating mRNA fate. However, critical role m6A regulation IVD remains unclear. Nucleus pulposus cell (NPC) senescence progression degeneration. Here, we uncovered explored regulatory mechanism NPC during Methods...
Abstract Elimination of bacterial infections and simultaneously promoting osteogenic differentiation are highly required for infectious bone diseases. Massive reactive oxygen species (ROS) can damage cells, while low ROS concentrations as a molecular signal regulate cellular fate. In this study, Janus‐ROS healing system is developed regeneration. An alendronate (ALN)‐mediated defective metal–organic framework (MOF) sonosensitizer prepared, which effectively clear Methicillin‐resistant...
Increased tissue stiffness is associated with various pathological processes, such as fibrosis, inflammation, and aging. The matrix of the nucleus pulposus (NP) tissues increases gradually during intervertebral disc degeneration (IDD), while mechanism through which NP cells sense react to remains unclear. In this study, results indicate that ferroptosis involved in stiff substrate-induced cell death. expression acyl-CoA synthetase long-chain family member 4 (ACSL4) group, mediates lipid...
Intervertebral disc degeneration (IDD) is the most critical pathological factor in development of low back pain. The maintenance nucleus pulposus (NP) cell and intervertebral integrity benefits largely from well-controlled mitochondrial quality, surveilled by dynamics (fission fusion) mitophagy, but outcome cellular context-dependent that remain to be clarified. Our studies revealed loss NLRX1 correlated with NP senescence IDD progression, which involve disordered quality. Further using...
As the leading cause of disability worldwide, low back pain (LBP) is recognized as a pivotal socioeconomic challenge to aging population and largely attributed intervertebral disc degeneration (IVDD). Elastic nucleus pulposus (NP) tissue essential for maintenance IVD structural functional integrity. The accumulation senescent NP cells with an inflammatory hypersecretory phenotype due other damaging factors distinctive hallmark IVDD initiation progression. In this study, we reveal mechanism...
Abstract Both O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) and endoplasmic reticulum-phagy (ER-phagy) are well-characterized conserved adaptive regulatory mechanisms that maintain cellular homeostasis function in response to various stress conditions. Abnormalities O-GlcNAcylation ER-phagy have been documented a wide variety of human pathologies. However, whether or is involved the pathogenesis intervertebral disc degeneration (IDD) largely unknown. In this study, we investigated...
As mesenchymal stem-cell-derived small extracellular vesicles (MSC-sEVs) have been widely applied in treatment of degenerative diseases, it is essential to improve their cargo delivery efficiency specific microenvironments lesions. However, the interaction between microenvironment recipient cells and MSC-sEVs remains poorly understood. Herein, we find that was significantly reduced under hypoxia inflammaging nucleus pulposus due activated endocytic recycling MSC-sEVs. Hypoxia-inducible...
Intervertebral disc degeneration (IVDD) is a prevalent cause of low back pain and leading contributor to disability. IVDD progression involves pathological shifts marked by low-grade inflammation, extracellular matrix remodeling, metabolic disruptions characterized heightened glycolytic pathways, mitochondrial dysfunction, cellular senescence. Extensive posttranslational modifications proteins within nucleus pulposus cells chondrocytes play crucial roles in reshaping the intervertebral...
Abstract Impaired transcription factor EB (TFEB) function and deficient autophagy activity have been shown to aggravate intervertebral disc (IVD) degeneration (IDD), yet the underlying mechanisms remain less clear. Protein posttranslational modifications (PTMs) are critical for determining TFEB trafficking transcriptional activity. Here, we demonstrate that is controlled by protein methylation in degenerated nucleus pulposus cells (NPCs), even though itself incapable of undergoing...
Abstract Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which represents a highly prevalent chronic aging‐associated disorder with large socio‐economic burden and great decline in quality life, contributing to pressing need for IVD treatments. Thus, finding effective disease‐modifying approaches postponing progression repairing degenerated intervertebral discs importance, even facing various challengeable obstacles. Bioactive functional materials exhibit...
Intervertebral disc degeneration (IDD) is the pathological reason of back pain and therapeutic approaches are still unsatisfactory. Recently, mesenchymal stem cell-derived small extracellular vesicles (EVs) have emerged as novel regenerative method for IDD. In this study, we intensively investigated mechanism EVs, found that vasorin protein enriched in EVs promoted proliferation matrix anabolism nucleus pulposus cells via Notch1 signaling pathway. Then, fabricated a thermoresponsive gel...
<title>Abstract</title> Mitochondrial double-stranded RNA (mtdsRNA), a long-stranded molecule generated by bidirectional transcription of the circular mitochondrial genome, can trigger type 1 interferon response activating pattern recognition receptors in cytoplasm during dysfunction. However, its regulatory and pathogenic mechanisms intervertebral disc degeneration are poorly understood. Here, we showed that mtdsRNA was abnormally elevated degenerative nucleus pulposus tissues. Furthermore,...
Critical-sized bone defects are usually accompanied by bacterial infection leading to inflammation and nonunion. However, existing biodegradable materials lack long-term therapeutical effect because of their gradual degradation. Here, a degradable material with continuous ROS modulation is proposed, defined as sonozyme due its functions sonosensitizer nanoenzyme. Before degradation, the can exert an effective sonodynamic antimicrobial through dual active sites MnN4 Cu2O8. Furthermore, it...
Abstract Background Growing evidence has suggested the role of stem cell‐derived small extracellular vesicles (sEVs) in intervertebral disc degeneration (IVDD). The cargo sorting sEVs, particularly miRNAs, may be influenced when donor cell is subjected to oxidative stress. Here, we discovered that miRNAs containing specific motifs are selectively sorted into intraluminal within mesenchymal cells (MSCs) response Methods Analysis miRNA cargoes sEVs derived from normal MSCs (C‐sEVs) or stressed...
Accumulating evidence indicates that ER-phagy serves as a key adaptive regulatory mechanism in response to various stress conditions. However, the exact mechanisms underlying pathogenesis of intervertebral disc degeneration remain largely unclear. In present study, we demonstrated RETREG1-mediated is induced by glucose deprivation (GD) treatment, along with ER activation and cell function decline. Importantly, was shown be crucial for survival under GD Furthermore, suggested an upstream...
Background: Glioma is the most common primary tumor of central nervous system and associated with poor overall survival, creating an urgent need to identify survival-associated biomarkers. C1ORF112, alpha-helical protein, overexpressed in some cancers; however, its prognostic role has not yet been explored gliomas. Thus, this study, we attempted address by determining value potential function C1ORF112 low-grade gliomas (LGGs). Methods: The expression normal tissues was analyzed using data...
Lower-grade gliomas (LGGs) are ubiquitous and fatal branches of brain neoplasm. Finding biomarkers related to diagnosis treatment is essential for the LGG. It possible reveal potential links between tumor microenvironment overall survival (OS) in LGG by mining mRNA expression profile from TCGA database. Our primary purpose was explore key genes that can be applied or microenvironment.Based on ESTIMATE algorithm, immune stromal scores were calculated measure extent infiltration cells cells,...