A5026020623- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Amyotrophic Lateral Sclerosis Research
- Bladder and Urothelial Cancer Treatments
- Treatment of Major Depression
- Ovarian function and disorders
- Lung Cancer Treatments and Mutations
- Multiple and Secondary Primary Cancers
- Polyomavirus and related diseases
- Cancer Immunotherapy and Biomarkers
- Pharmacovigilance and Adverse Drug Reactions
- Cholinesterase and Neurodegenerative Diseases
- Economic and Financial Impacts of Cancer
- Nuclear Receptors and Signaling
- Reproductive Biology and Fertility
- Mental Health Research Topics
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Cerebrovascular and genetic disorders
- Reproductive Health and Technologies
- Prion Diseases and Protein Misfolding
- Functional Brain Connectivity Studies
- Gastric Cancer Management and Outcomes
- Neurological diseases and metabolism
Merck (Germany)
2018-2025
European Medicines Agency
2024-2025
Aarhus University Hospital
2022
Boehringer Ingelheim (Germany)
2015-2019
Lundbeck (Denmark)
2004-2016
Issy Media (France)
2014
Communication, Information, Médias
2013
Inserm
1998-2011
Sanofi (France)
2011
Hôpital Louis-Mourier
2003-2006
Frontotemporal dementia (FTD), characterized by behavioural and language disorders, is a clinically, genetically pathologically heterogeneous group of diseases. The most recently identified the four known genes GRN, associated with 17q-linked FTD ubiquitin-immunoreactive inclusions. GRN was analysed in 502 probands frontal variant (fvFTD), motoneuron disease (FTD-MND), primary progressive aphasia (PPA) corticobasal degeneration syndrome (CBDS). We studied clinical, neuropsychological brain...
Background: Interstitial lung disease (ILD) is one of the leading causes mortality in patients with systemic sclerosis (SSc). To further understand this patient population, we present first systematic review on epidemiology SSc and SSc-associated ILD (SSc-ILD). Methods: Bibliographic databases web sources were searched for studies including SSc-ILD Europe North America (United States Canada). The was limited to publications English, German, French, Spanish, Italian, Portuguese, published...
Abstract To establish phenotype–genotype correlations in early‐onset parkinsonism, we have compared the phenotype of a large series 146 patients with and 250 without parkin mutations. Although no single sign distinguished groups, mutations had significantly earlier more symmetrical onset, dystonia often at onset hyperreflexia, slower progression disease, tendency toward greater response to levodopa despite lower doses. After forward stepwise multiple logistic regression analysis, brisk...
Atherosclerosis is a chronic inflammatory disease of the blood vessels. Toll-like receptor 4 (TLR4) transmembrane that involved in mediating responses to bacterial endotoxin and other ligands. The aim this study was search for an association between common functional polymorphism TLR4--Asp299Gly--and acute coronary syndrome.We conducted case-control 183 patients with syndromes 216 controls. We screened TLR4 gene Asp299Gly using 5' fluorogenic assay. 299Gly allele associated decreased risk...
Frontotemporal dementia and parkinsonism (FTDP) is the second most common cause of neurodegenerative after Alzheimer's disease. Recently, several kindreds with an autosomal dominant form FTDP have been reported in some families pathological locus was mapped to a 2 cM interval on 17q21–22. The MAPT gene, located 17q21 coding for human microtubule-associated protein tau, strong candidate since tau-positive neuronal inclusions observed brains from patients. Direct sequencing exonic sequences 21...
We conducted a French multicentric cross-sectional study to describe in detail the demographic, neurological and behavioural characteristics of frontal variant frontotemporal dementia (fvFTD) characterize pattern brain perfusion SPECT comparison healthy control group. A total 68 fvFTD patients had technetium-99m-ECD at inclusion, 61 which also underwent an in-depth evaluation including 70 items assessing behaviour, language affect/emotion onset inclusion. The mean age-at-onset was 60.4 +/-...
The scientific community and decision-makers are increasingly concerned about transparency reproducibility of epidemiologic studies using longitudinal healthcare databases. We explored the extent to which published pharmacoepidemiologic commercially available databases could be reproduced by other investigators. identified a nonsystematic sample 38 descriptive or comparative safety/effectiveness cohort studies. Seven were excluded from reproduction, five because violation fundamental design...
Frontotemporal dementia (FTD) is the second most frequent type of neurodegenerative dementias. Mutations in progranulin gene (GRN, PGRN) were recently identified FTDU-17, an FTD subtype characterized by ubiquitin-immunoreactive inclusions and linkage to chromosome 17q21. We looked for PGRN mutations a large series 210 patients (52 familial, 158 sporadic) accurately evaluate frequency both sporadic familial FTD, with associated motoneuron disease (FTD-MND), as well study clinical phenotype...
Frontotemporal dementia (FTD) refers to a disease spectrum including the behavioral variant FTD (bvFTD), primary progressive aphasia (PPA), supranuclear palsy/corticobasal degeneration syndrome (PSP/CBDS), and with amyotrophic lateral
We tested the efficacy and tolerability of one-year treatment with memantine (10 mg bid) in behavioral variant frontotemporal dementia (bvFTD). BvFTD patients aged 45 to 75 years, a Mini-Mental Status Examination (MMSE) score ≥19, were enrolled national, randomized, double-blind, placebo-controlled (DBPC), Phase II trial. The primary endpoint was CIBIC-Plus (Clinician's Interview-Based Impression Change Plus Caregiver Input). secondary endpoints included: Neuropsychiatric Inventory (NPI),...
Frontotemporal dementia associated with motor neuron disease (FTD-MND) is a rare neurodegenerative disorder that may be inherited by autosomal dominant trait. No major gene has been identified but locus was mapped on chromosome 9 (9p21.3-p13.3).Ten French families FTD-MND were tested for linkage to the 9p21.3-p13.3 region. We report extensive mutation screening in 9p-linked and their clinical characteristics.We six new evidence 9p. Cumulative multipoint LOD score values positive between...
The authors report a presenilin 1 (PSEN1) mutation (L113P) in family with six cases of dementia. patients had personality changes and behavioral disorders, whereas spatial orientation praxis were preserved late the course illness. Neuroimaging features consistent diagnosis frontotemporal conclude that PSEN1 mutations can be associated clinical
<h3>Background</h3> Recent studies have shown an association between extended tau haplotype (H1) that covers the entire human<i>tau</i>gene and progressive supranuclear palsy or, more inconsistently, other neurodegenerative disorders, such as corticobasal degeneration, Parkinson disease, Alzheimer frontotemporal dementia (FTD). In addition, disease-causing mutations in the<i>tau</i>gene on chromosome 17 been detected some families with autosomal dominant FTD parkinsonism. FTD, pathological...
In general, antidepressant drugs are regarded as too slow acting. Most patients who benefit from treatment require more than 2 weeks of therapy to respond treatment. An efficacious and well-tolerated drug with an earlier onset effect would be greater interest clinicians patients. To study the escitalopram, a selective serotonin reuptake inhibitor (SSRI), data were pooled controlled randomized clinical double-blind trials comparing this other (SSRIs venlafaxine XR) in major depressive...
Systemic anticancer therapy for locally advanced or metastatic urothelial carcinoma (la/mUC) is associated with efficacy benefits, including longer overall survival (OS), but many patients remain untreated. This observational, real-world, national study aimed to investigate factors receiving systemic la/mUC in England. Adults diagnosed between 2013 and 2019 were identified the National Cancer Registration Dataset followed until March 2021. Healthcare comorbidity data obtained from Hospital...
Escitalopram is an effective, well-tolerated treatment for major depressive disorder in both primary and specialist settings. This analysis compared the efficacy of escitalopram with citalopram patients severe depression [defined as a score ≥30 Montgomery–Åsberg Depression Rating Scale (MADRS)]. Data from three clinical trials were used this pooled analysis. A total 506 severely depressed included (169 received escitalopram, 171 166 placebo). Mean change baseline MADRS scores (primary...
Background: The National Death Index (NDI) is the gold standard for mortality data in United States (US) but has a time lag and can be operationally intensive. This validation study assesses accuracy of various sources with NDI. Methods: secondary analysis an advanced cancer cohort US between January 2010 December 2018, established NDI linkage. Mortality sources, inpatient discharge, disenrollment, death master file (DMF), Center Medicare Medicaid Services (CMS), Utilization management...
Building on existing practices, our vision is that by 2030, clinical evidence generation will be further guided the patient voice and informed data knowledge; study design driven research questions to addressed; trials more efficient impactful; real-world (RWE) enabled its value fully established; trust built through transparency (Figure 1). Excellence of heart every well-informed decision development, authorization, reimbursement, use, monitoring medicines. While healthcare makers continue...
This retrospective study examined real-world treatment patterns and outcomes in patients diagnosed with metastatic Merkel cell carcinoma (MCC) England from 2013 to 2020. Among 667 identified, only 30% received systemic anticancer treatment, of whom 39% first-line avelumab. Longer median overall survival (OS) was observed treated avelumab vs other treatments, including stage III MCC (37.8 13.0 months) or IV (19.9 7.2 months).