A5016027728- Estrogen and related hormone effects
- Thyroid Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Inflammatory mediators and NSAID effects
- TGF-β signaling in diseases
- Endometriosis Research and Treatment
- Breast Cancer Treatment Studies
- Cancer Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cancer and Skin Lesions
- Renal and related cancers
- Nonmelanoma Skin Cancer Studies
- IgG4-Related and Inflammatory Diseases
- Medical Imaging Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Pancreatitis Pathology and Treatment
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Histiocytic Disorders and Treatments
- Medicinal plant effects and applications
Kitasato University
2010-2024
Kitasato University Hospital
2009-2020
Mayo Clinic
2004-2006
ObjectivesWe focused on the differences in molecular mechanisms early stages of endometriosis-associated ovarian endometrioid carcinoma (OEMCa) and clear cell (OCCCa).
// Masashi Akiya 1 , Masaaki Yamazaki Toshihide Matsumoto Yusuke Kawashima 2 Yasuko Oguri Sabine Kajita Daiki Kijima Risako Chiba Ako Yokoi Hiroyuki Takahashi Yoshio Kodera and Makoto Saegusa Department of Pathology, Kitasato University School Medicine, Sagamihara, Kanagawa 252-0374, Japan Center for Disease Proteomics, Science, University, Correspondence to: Saegusa, email: msaegusa@med.kitasato-u.ac.jp Keywords: LEFTY, ovarian clear cell carcinoma, proliferation, apoptosis, TGF-beta...
The left-right determination factor (LEFTY) is a novel member of the TGF-β/Smad2 pathway and belongs to premenstrual/menstrual repertoire in human endometrium, but little known about its functional role endometrial carcinomas (Em Cas). Herein, we focused on LEFTY expression association with progesterone therapy Em Cas. Regulation function LEFTY, as well associated molecules including Smad2, ovarian hormone receptors, GSK-3β, cell cycle-related factors, were assessed using clinical samples...
We report a case of immunoglobulin (ig)-g4-related thyroiditis associated with graves' disease. 45-year-old man was diagnosed disease due to asymptomatic enlarged thyroid gland and high serum levels thyrotropin receptor antibodies hormones. surgical resection the performed because further enlargement severe fluctuations in hormonal levels, despite medical therapy combination an antithyroid drug hormone preparation. macroscopic examination resected revealed grayish-white diffuse swelling,...
BRCAness is defined as the set of traits in which BRCA1 dysfunction, arising from gene mutation, methylation or deletion, results DNA repair deficiency. In present study, we addressed BRCAness, therapeutic efficacy, recurrence, and survival patients with triple negative breast cancer (TNBC) who were treated neoadjuvant chemotherapy at Kitasato University Hospital, Japan, between April 2006 October 2012. was determined by preoperative core needle biopsy (CNB) specimens surgical specimens....
Mild periodic acid–Schiff (mPAS) staining can discriminate non‐ O ‐acetylated (mPAS‐positive) from (mPAS‐negative) epithelial sialoglycoproteins in human colonic mucosa, allowing the three haplotypes expressed a single polymorphic autosomal gene ( oat ) to be distinguished. In heterozygotes, we previously demonstrated wholly mPAS‐positive (stem cell mutated) crypts and clusters of two or more significantly increased with duration ulcerative colitis. To establish whether such an increase...
Although the anticancer effects of radiation therapy for patients with uterine cervical squamous cell carcinoma (U-SCC) are widely acknowledged, little is known about resultant morphological alterations in tumour tissue kinetics.To make a detailed assessment possible roles survivin expression apoptosis and proliferation U-SCC during therapy.181 biopsy specimens from 55 consecutive U-SCCs receiving were studied using combined (apoptosis) immunohistochemical (MIB-1 survivin) approach. The...
Transactivation response DNA ‐binding protein 43 k D a ( TDP ‐43) is key of sporadic amyotrophic lateral sclerosis ALS ), and phosphorylated form ‐43 (p‐ major pathological that accumulates in . p‐ found not only primary motor neurons, but often propagates to non‐motor systems as well. However, pallido‐nigro‐luysian PNL ) degeneration PNLD rarely associated with We describe here 68‐year‐old patient presenting severe He had difficulty walking due poor movement his right leg, was diagnosed...
We report a 65-year old female with advanced papillary thyroid carcinoma involving the critical vessels including common carotid artery (CCA).She initially refused surgery and lenvatinib (LEN) was used in neoadjuvant setting.Primary tumor effectively shrank by LEN without any adverse effect.Total thyroidectomy modified neck dissection were curatively performed.Tumor invading into internal jugular vein exhibited remarkable response to almost replaced necrosis fibrosis.CCA surrounded fibrosis...
Expression of Nodal, a member the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs variety human malignancy. However, little known about involvement ovarian tumorigenesis. Herein, we focused on functional roles Nodal endometriosis-carcinoma lesions. Regulation and function associated molecules, including Smad2, GSK-3β, several cell kinetics-related were assessed using clinical samples consisting 108 carcinomas 33 endometriotic lesions, as well...
The Japan Clinical Oncology Group 1505 trial is a single-arm multicentre prospective study that examined the possibility of non-surgical follow-up with endocrine therapy for patients low-grade ductal carcinoma in situ. In study, eligible criteria included histopathological findings comprising low to intermediate nuclear grade and absence comedo necrosis, cases were entered according local diagnosis. Nuclear largely based on Consensus Conference (1997), whereas necrosis judged Rosen's (2017)....
ABSTRACT Immunoglobulin (Ig) G4–related disease (IgG4-RD) is a systemic inflammatory characterised by elevated serum IgG4, IgG4+ cell infiltration, storiform fibrosis, and obliterative phlebitis. While IgG4-RD can affect various organs, gastrointestinal tract involvement less common. Here, we report 70-year-old female with complicated diffuse chronic inflammation, which led to small intestinal perforation. She had been suffering from anorexia, abdominal pain, vomiting, diarrhoea hospitalised...