A5042718339- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- Balance, Gait, and Falls Prevention
- Muscle activation and electromyography studies
- Vestibular and auditory disorders
- Motor Control and Adaptation
- EEG and Brain-Computer Interfaces
- Cerebral Palsy and Movement Disorders
- Optical Imaging and Spectroscopy Techniques
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Cardiovascular and exercise physiology
- Neural dynamics and brain function
- Cardiovascular Health and Disease Prevention
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Neural and Behavioral Psychology Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Neurological Disorders and Treatments
- Orthopedic Surgery and Rehabilitation
- Nitric Oxide and Endothelin Effects
- Foot and Ankle Surgery
- Health and Lifestyle Studies
Emory University
2017-2024
University of Kansas Medical Center
2021-2024
University of Minnesota Medical Center
2023-2024
University of Kansas
2021-2024
American Physical Therapy Association
2024
University of Minnesota
2024
University of Minnesota System
2024
Amway (United States)
2023
Tallahassee Orthopedic Clinic
2023
Newark Hospital
2023
For walking rehabilitation after stroke, training intensity and duration are critical dosing parameters that lack optimization.
Background. A higher energy cost of walking poststroke has been linked to reduced performance and participation in the community. Objective. To determine contribution postintervention improvements speed spatiotemporal gait asymmetry reduction after stroke. Methods. In all, 42 individuals with chronic hemiparesis (>6 months poststroke) were recruited participate 12 weeks rehabilitation. The walking, speed, step length, swing time, stance time asymmetries calculated pretraining...
Recent rehabilitation efforts after stroke often focus on increasing walking speed because it is associated with quality of life. For individuals poststroke, propulsive force generated from the paretic limb has been shown to be correlated speed. However, little known about relative contribution versus nonparetic forces changes in speed.The primary purpose this study was determine each during modulation within a session and as result 12-week training program.Gait analysis performed...
Heightened reliance on the cerebral cortex for postural stability with aging is well-known, yet cortical mechanisms balance control, particularly in relation to function, remain unclear. Here we aimed investigate motor activity level of challenge presented during reactive recovery and identify circuit-specific interactions between prefrontal or somatosensory regions metrics function that predict fall risk. Using electroencephalography, assessed beta power, coherence reactions perturbations...
Information regarding how motor units are controlled to produce forces in individuals with stroke and the mechanisms behind muscle weakness movement slowness can potentially inform rehabilitation strategies. The purpose of this study was describe rate coding mechanism poststroke during both constant (n = 8) rapid 4) force production tasks. Isometric ankle dorsiflexion force, unit action potentials, surface electromyography were recorded from paretic nonparetic tibialis anterior. In limb,...
Context: Current research into the etiology of joint instability has yielded inconsistent results, limiting our understanding how to prevent and treat ligamentous injury effectively. Recently, cortical reorganization was demonstrated in patients with injury; however, these neural changes have not been assessed relative laxity. Objective: The purpose current study determine if excitability inhibition occur subjects functional ankle instability, as well investigate relationship between...
Background/Objective. We investigated interhemispheric interactions in stroke survivors by measuring transcranial magnetic stimulation (TMS)–evoked cortical coherence. tested the effect of TMS on coherence during rest and active muscle contraction compared older adults. evaluated relationships between coherence, paretic motor function, ipsilateral silent period (iSP). Methods. Participants with (n = 19) without 14) chronic either rested or maintained a hand simultaneous recordings evoked...
The mechanisms underlying associations between cognitive set shifting impairments and balance dysfunction are unclear. Cognitive refers to the ability flexibly adjust behavior changes in task rules or contexts, which could be involved adjusting recovery different such as direction body is falling. Prior studies found severe populations experiencing frequent falls. objective of this study was test whether expressed successful older adults with high clinical (N = 19, 71 ± 7 years, 6 female)....
Abnormal brain excitability influences recovery after stroke at which time a prolonged transcranial magnetic stimulation (TMS)-induced electromyographic silent period is thought to reflect abnormal inhibitory interneuron excitability. Cortical can be probed directly during the using concurrent electroencephalography (EEG) of TMS-evoked responses.The primary study objectives were characterize cortical potentials (TEPs) EEG and investigate associations with persistent hand arm motor...
Background: Paired associative stimulation (PAS) combining repeated pairing of electrical a peripheral nerve with transcranial magnetic (TMS) over the primary motor cortex (M1) can induce neuroplastic adaptations in human brain and enhance learning neurologically-intact individuals.However, extent to which PAS is an effective technique for inducing plasticity improving function individuals post-stroke unclear.Objective: The objective this pilot study was investigate effects single session...
Cortical beta oscillations (13–30 Hz) reflect sensorimotor processing, but are not well understood in balance recovery. We hypothesized that cortical activity would increase under challenging conditions. predicted greater power when was challenged, either by more difficult perturbations or lower ability. In 19 young adults, we measured over motor areas (electroencephalography, Cz electrode) during three magnitudes of backward support -surface translations. Peak early (50–150 ms), late...
Recent research demonstrated that the symmetry of corticomotor drive with paretic and nonparetic plantarflexor muscles was related to biomechanical ankle moment strategy people chronic stroke used achieve their greatest walking speeds. Rehabilitation strategies promote balance might improve poststroke mechanics enhance functional ambulation.The study objectives were test effectiveness a single session gait training using electrical stimulation (FES) plantarflexion determine whether changes...
Background Physical exercise may support brain health and cognition over the course of typical aging. The goal this nonrandomized clinical trial was to examine effect an acute bout aerobic on blood flow neurotrophic factors associated with response function in older adults without possession Apolipoprotein epsilon 4 (APOE4) allele, a genetic risk factor for developing Alzheimer’s. We hypothesized that adult APOE4 carriers would have lower cerebral regulation demonstrate blunted compared...
Over the course of aging, there is an early degradation cerebrovascular health, which may be attenuated with aerobic exercise training. Yet, acute response to a single bout remains elusive, particularly within key brain regions most affected by age-related disease processes. We investigated global and region-specific cerebral blood flow (CBF) 15 minutes moderate-intensity in older adults (≥65 years; n = 60) using arterial spin labeling magnetic resonance imaging. Within 0-6 min...
Imbalance of corticomotor excitability between the paretic and nonparetic limbs has been associated with extent upper extremity motor recovery poststroke, is greatly influenced by specific testing conditions such as presence or absence volitional muscle activation, may vary across groups. However, despite its clinical importance, poststroke drive to lower muscles not thoroughly investigated. Additionally, whereas conventional gait rehabilitation strategies for stroke survivors focus on limb...
To investigate the effects of sensory reweighting on postural control and cortical activity in individuals with Parkinson's disease (PD) compared to age-matched controls using a virtual reality organization test (VR-SOT). Cross-sectional pilot study. University research laboratory. Ten participants idiopathic 11 age- sex-matched without neurologic disorders. Not applicable. Changes center pressure (COP) electroencephalography (EEG) (ie, power) alpha band theta/beta ratio recorded during...
Background: The inability to flexibly modulate motor behavior with changes in task demand or environmental context is a pervasive feature of impairment and dysfunctional mobility after stroke. Objective: purpose this study was test the reactive modulatory capacity lower-limb primary cortical (M1) networks using electroencephalography (EEG) measures activity evoked by transcranial magnetic stimulation (TMS) evaluate their associations clinical biomechanical walking function chronic Methods:...
Repeated pairing of electrical stimulation a peripheral nerve with transcranial magnetic (TMS) over the primary motor cortex (M1) representation for target muscle can induce neuroplastic adaptations in human brain related to learning. The extent which state during this form paired associative (PAS) influences degree and mechanisms neuroplasticity or learning is unclear. Here, we investigated effect volitional contraction PAS on: (1) measures general corticomotor excitability intracortical...
Background . Despite intensive rehabilitation efforts, most stroke survivors have persistent functional disability of the paretic arm and hand. These motor impairments may be due in part to maladaptive changes structural connections between brain regions. The following early stage clinical trial study protocol describes a noninvasive stimulation approach target transcallosally mediated interhemispheric ipsi- contralesional cortices (iM1 cM1) using corticocortical paired associative (ihPAS)....